Clinical trials: Randomized-controlled Trial
Agitation Related to Dementia
The Effect of Cannabis on Dementia Related Agitation and Aggression
The most common syndrome in patients with severe dementia is agitated behavior, which is often characterized by a combination of violent behavior (physical or verbal), restlessness, and inappropriate loudness.
- Trial name
- NCT03328676
- Testing
- Cannabis
- Where
- Israel
- Volunteers
- 64 people
- Sponsor
- TO Pharmaceuticals
Chronic Kidney Disease, Diabetic Kidney Disease
A Trial to Learn More About How BAY2327949 Works and How Safe it is in Patients Whose Kidneys Are Damaged Due to High Blood Sugar Levels or High Blood Pressures, and With a Further Disease of the Heart or the Blood Vessels.
In people with type 2 diabetes (T2D), the body makes insulin, but cannot use it well. This results in high blood sugar levels causing damage to the blood vessels inside the kidneys.
- Trial name
- ASSESS-CKD (NCT04661917)
- Testing
- BAY2327949
- Where
- 36 sites in Austria, Denmark and 5 more
- Sponsor
- Bayer
Cold-water Immersion, Protein-carbohydrates Supplementation
Effects on CK, RPE, VAS Scale and Physical Performance of Three Recovery Methods in Elite Basketball Players
The aim of this study was to compare the effects of cold water intermittent ion (CWI), carbohydrate and protein supplementation (SUPPL), and active recovery (ACT) on creatine kinase (CK), perceptual and performance markers of…
- Conditions
- Cold-water Immersion, Protein-carbohydrates Supplementation, Active Recovery, Placebo
- Trial name
- NCT05805540
- Testing
- Cold-water immersion, Protein-carbohydrates supplementation, Active recovery
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Stroke
Self-regulated Constraint-induced Movement Therapy in Subacute Stroke Patients
Emerging research suggests the use of self-regulation (SR) strategies at improving functional regain in patients with brain injury.
- Trial name
- NCT02480140
- Testing
- Self-regulated constraint-induced movement therapy, Constraint-induced movement therapy, Conventional occupational therapy
- Where
- 2 sites in Hong Kong
- Volunteers
- 76 people
- Sponsor
- University of Western Sydney
Schizophrenia
Paliperidone Extended-Release (ER) Versus Risperidone for Neurocognitive Function in Patients With Schizophrenia
Primary objective: To examine whether the switch to paliperidone ER from risperidone improves cognitive function in stabilized patients with schizophrenia.
- Trial name
- NCT00827840
- Testing
- Paliperidone ER, Risperidone
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Chonnam National University Hospital
Frail Older People Undergoing Inpatient Rehabilitation
Mobility in Older People
The main aim of this study is to investigate whether increasing the amount of physical activity in frail older people during hospital based rehabilitation is associated with better mobility outcomes compared to usual care.
- Trial name
- MOVE (NCT01910740)
- Testing
- Enhanced Physical Activity, Usual Care, Social Interaction
- Where
- Australia
- Volunteers
- 198 people
- Sponsor
- La Trobe University
Rectal Cancer Surgery
Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery
This study aims to demonstrate that a preoperative combination of mechanical bowel preparation and oral antibiotics, before elective laparoscopic rectal cancer surgery, is associated with a reduction of postoperative surgical…
- Trial name
- PREPACOL2 (NCT03491540)
- Testing
- Sennosides colonic preparation, Oral Gentamycin, Oral Ornidazole
- Where
- France
- Volunteers
- 414 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluid Removal, Critically Ill
Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy
Macrohemodynamic impact of fluid removal with net ultrafiltration in patients with continuous renal replacement therapy. A monocentric ancillary study of the EarlyDry randomized controlled trial.
- Conditions
- Fluid Removal, Critically Ill, Continuous Renal Replacement Therapy, Fluid Overload
- Trial name
- NCT06425289
- Testing
- Macrohemodynamic parameters
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Anesthesia, Medical Education
Mental Visualization as a Learning Tool in Anesthesia
The purpose of this study is to evaluate the benefit of adding mental visualization to a training program in medical education. Undergraduate medical students will be randomized before participating in a training program on…
- Trial name
- NCT04159389
- Testing
- Mental visualization
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Grenoble Alps
Tension-Type Headache
Evidence-Based Osteopathy for Tension-Type Headache (EBOTTH)
Tension-type headache (TTH) is a very common primary headache disorder, with important costs for both patients and society. Often these patients are not willing to take prophylactic medications and resort to complementary…
- Trial name
- EBOTTH (NCT02592850)
- Testing
- osteopathic manipulative treatment
- Sponsor
- University of Milano Bicocca
Low Back Pain, Mechanical, Complementary Therapies
Craniosacral Therapy as a Self-help Strategy for Patients With Chronic Non-specific Back Pain
Craniosacral Therapy (CST) is a non-manipulative, very gentle manual treatment method. Although the mechanisms of action have not yet been investigated sufficiently, initial clinical trials support CST efficacy/effectiveness in…
- Conditions
- Low Back Pain, Mechanical, Complementary Therapies, Progressive Muscle Relaxation
- Trial name
- CRANIO4ME (NCT04199091)
- Testing
- Craniosacral Therapy (CST) self-help techniques, Progressive Muscle Relaxation (PMR)
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Universität Duisburg-Essen
Abdominal Surgery, Hypertension
The Effect of Laughter Yoga on Nurses' Perceived Stress Burnout and Life Satisfaction During the Pandemic Period
This study aimed to determine the effects of laughter yoga on the perceived stress, burnout and life satisfaction of nurses working actively during the pandemic period.
- Conditions
- Abdominal Surgery, Hypertension, Done Laughter Yoga Before, Epilepsy
- Trial name
- NCT05317091
- Testing
- Laughter yoga practiced
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Depression
Escitalopram for the Prevention of PEGASYS-associated Depression in Hepatitis C Virus-infected Patients
Primary end points incidence of depression defined as a Montgomery Asberg Depression Scale Score (MADRS) of 13 or higher during antiviral therapy (up to 48 weeks, depending on genotype) effect of an antidepressive pre-treatment…
- Trial name
- CIPPAD (NCT00136318)
- Testing
- Escitalopram, Peginterferon alfa-2a, Ribavirin
- Where
- Germany
- Volunteers
- 208 people
- Sponsor
- Charite University, Berlin, Germany
Dental Implant
Immediate Versus Conventional Loading of Early Placed Dental Implant Supporting Single Crowns
This study focuses on examining the efficacy and clinical performance of immediate loading of early placed single implants. The aim of the randomized controlled trial is to compare between two loading protocols (immediate versus…
- Trial name
- NCT06693297
- Testing
- Immediate loading of early placed implants, Conventional loading of early placed implants
- Where
- Jordan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Hypertension,Essential, Hypertension
Recreational Futsal for Controlled Hypertension
Arterial hypertension (HT) was the leading global contributor for premature deaths in 2015. Its treatment includes medication and lifestyle changes, namely diet and regular exercise, which has shown to have an inverse…
- Conditions
- Hypertension,Essential, Hypertension, Blood Pressure Disorders, Blood Pressure
- Trial name
- HyperFut (NCT05185297)
- Testing
- Recreational Futsal
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- University Institute of Maia
Muscle Tone, Psychological State
Mandibular Stretching and 4-4-8 Breathing Exercises on Autonomic Nervous System Activity
Mandibular stretching exercises and breathing techniques may influence autonomic nervous system activity, muscle tone, and psychological state.
- Conditions
- Muscle Tone, Psychological State, Autonomic Nervous System
- Trial name
- MSE-BR (NCT07472010)
- Testing
- Mandibular Stretching Exercise, 4-4-8 Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mehin Mammadzada
Urinary Bladder, Neurogenic
Urodynamic and Clinical Efficacy of Mirabegron for Neurogenic Bladder Patients
The proposed study is a randomized, double blind placebo controlled multicenter study to determine the effectiveness of mirabegron in the treatment of neurogenic bladder dysfunction.
- Trial name
- NCT02044510
- Testing
- Mirabegron
- Where
- 5 sites in Canada
- Volunteers
- 32 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bladder Perforation, Retropubic Midurethral Sling
Retropubic Hydrodissection and Trocar-induced Bladder Perforation During Retropubic Midurethral Slings
Retropubic midurethral slings are a common and effective treatment for stress urine incontinence. The trocar that is attached to the mesh material can hit the bladder which is called a perforation.
- Conditions
- Bladder Perforation, Retropubic Midurethral Sling, Retropubic Hydrodissection
- Trial name
- NCT07208682
- Testing
- retropubic hydrodissection
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Sepsis, Acute Respiratory Distress Syndrome
Corticosteroids in Hyperinflammatory Phenotype of Critical Illness
The goal of this clinical trial is to learn whether methylprednisolone improves outcomes in critically ill patients with a hyperinflammatory phenotype. It will also evaluate the safety of methylprednisolone at different doses.
- Trial name
- CHIP (NCT07511582)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Bin Du
Periapical Lesion
Effect of Piezoelectric Device on Intraoperative Hemorrhage Control and Quality of Life
Most osteotomies and apicoectomies in periapical surgeries are performed by surgical carbide or diamond burs. But greater pressure is applied during cutting which causes more thermal and mechanical damage to the bone.
- Trial name
- NCT06240182
- Testing
- conventional surgery, piezoelectric device
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
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