Clinical trials: Randomized-controlled Trial
Posterior Fossa Tumor
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.
The goal of this clinical trial is to evaluate the effects of ultrasound-guided versus blind greater occipital nerve block (GONB), with or without Dexmedetomidine as an adjuvant, in pediatric patients undergoing posterior fossa…
- Trial name
- NCT07878156
- Testing
- Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Mild Cognitive Impairment
The Impact of Physical Exercise on Working Memory in Elderly People With Mild Cognitive Impairment
Age-related cognitive decline has evolved into a global public health concern, with deteriorated executive function serving as its predominant manifestation.
- Trial name
- NCT07644156
- Testing
- Resistance band exercise intervention, Brisk walking intervention, Eight-Section brocade exercise intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai University of Sport
Chronic Obstructive Pulmonary Disease
The Multicenter Topic Trial
The purpose of this protocol is to test the safety, pharmacokinetics, and pharmacodynamics of the Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, ivacaftor in patients with chronic obstructive pulmonary…
- Trial name
- NCT04066751
- Testing
- Ivacaftor
- Sponsor
- University of Alabama at Birmingham
Public Health Nursing
The Effect of Disaster Training on the Perception of Disaster Response Competence
Due to the increase in disasters, humanity is facing an increasing threat to life and property. Disasters occur with little warning and can last for hours or months.
- Trial name
- NCT06438029
- Testing
- Education group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- FATOŞ UNCU
Breast Cancer
Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
This study will compare DS-8201a to physician choice standard treatment. Participants must have HER2-low breast cancer that has been treated before.
- Trial name
- NCT03734029
- Testing
- Trastuzumab deruxtecan (DS-8201a), Capecitabine, Eribulin
- Where
- 208 sites in United States, Austria and 18 more
- Volunteers
- 557 people
- Sponsor
- Daiichi Sankyo
Chronic Low-back Pain, Anxiety
EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain
The aim of this randomized controlled trial (RCT) is to assess outcomes for virtual reality therapy (including pain intensity, pain interference, anxiety, depression, physical function, sleep, behavioral skills development…
- Conditions
- Chronic Low-back Pain, Anxiety, Depression
- Trial name
- AVR_HEOR (NCT05263037)
- Testing
- EaseVRx
- Where
- United States
- Volunteers
- 1,093 people
- Sponsor
- AppliedVR Inc.
Diabetes, Diabetes Mellitus
Computer-Assisted Cancer Risk Behavior Counseling
To test whether or not giving patients information before their doctor visits changes the care they receive and what type of information is best to give before the doctor visit.
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- NCT00242645
- Testing
- Health Information, Preventive Services, Computer tailored information
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Loneliness, Social Isolation
Need to be Needed (N2BN) Intervention
The proposed study is a randomized, controlled trial (RCT) that will examine the effectiveness of an intervention designed to reduce social isolation and loneliness of adults with serious mental illness (SMI).
- Trial name
- N2BN RCT (NCT06510439)
- Testing
- Need to Be Needed Intervention, Active Control Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Temple University
Health-Related Behavior
Effectiveness of a mHealth App for Supporting the First 1000 Days of Life
Recent development in information and communication technologies has enabled the disruptive expansion of electronic health (eHealth) and mobile health (mHealth).
- Trial name
- CARE1000 (NCT05500339)
- Testing
- M-health App, Standard care
- Where
- Italy
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- IRCCS Burlo Garofolo
Pain, Postoperative
Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial
The goal of this study is to compare the pain, edema and trismus of pre-operative versus post-operative submucosal dexamethasone in lower third molar surgical extraction done in healthy population.This is comparative study, will…
- Trial name
- NCT06160180
- Testing
- Dexamethasone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Lung Resection Surgery, Anesthesia General
Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery
The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and…
- Trial name
- NCT07461779
- Testing
- Medicinal gas - oxygen (Nippon Gases 200 bar), CPAP, Oxygen therapy according to standard clinical practice
- Where
- Spain
- Volunteers
- 177 people
- Sponsor
- Francisco Andres de la Gala
Osteo Arthritis Knee
Comprehensive Geriatric Assessment in Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis, and is characterized by joint pain and stiffness leading to functional decline and relevant loss in quality of life.
- Trial name
- NCT05659979
- Testing
- Comprehensive geriatric assessment
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Depression
Evaluation of the Effectiveness of a Web-based Treatment Program for Depression for the Reduction of Depressive Symptoms
200 persons with depression are recruited via internet depression forums devoted to depression and are randomly assigned either to the online program deprexis or to a wait-list control condition.
- Trial name
- NCT01401296
- Testing
- Deprexis, Wait-list
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Regional Anesthesia Morbidity, Hip Surgeries
Pericapsular Nerve Group Block vs. Fascia Iliaca Compartment Block vs. Caudal Block for Hip Surgeries
The study aims to compare the effect of pericapsular nerve group block versus fascia iliaca compartment block versus caudal block regarding Postoperative analgesia in children undergoing hip surgeries.
- Conditions
- Regional Anesthesia Morbidity, Hip Surgeries, Perioperative Analgesia
- Trial name
- NCT07137962
- Testing
- PENG Block, FICB Block, Caudal Block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oxidative Stress, Fetal Distress
Maternal Oxygen Use During Delivery and Cord Blood Superoxide Dismutase
When exposed to oxygen immediately after birth, newborns suffer from an oxidative stress with a significant decrease in serum concentration of the anti-oxidant enzyme superoxide dismutase.
- Trial name
- NCT01042262
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Washington University
Hirschsprung Disease
A Trial on Conservative Treatment for Infants' Hirschsprung Disease
The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in infants with short or normal-segment Hirschsprung disease.
- Trial name
- NCT01985646
- Testing
- surgery treatment, anal dilation, colonic lavage
- Volunteers
- 48 people
- Sponsor
- Tongji Hospital
Delayed Cord Clamping, Umbilical Cord Milking
The Hematologic Impact of Umbilical Cord Milking Versus Deferred Cord Clamping in Premature Neonates.
Comparing the beneficial effect of cord milking versus deferred cord clamping in preterm neonates. A randomized controlled trial
- Conditions
- Delayed Cord Clamping, Umbilical Cord Milking, Preterm Neonates
- Trial name
- NCT03147846
- Testing
- delayed cord clamping, cord milking
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Pregnant Women, Cesarean Section
Evaluation of the Absence of Intraoperative Bladder Catheterization in Case of Planned Cesarean Section
The hypothesis of this trial is that the absence of systematic bladder catheterization in patients performing spontaneous urination in the hour preceding the planned cesarean section under spinal anesthesia would not lead to more…
- Trial name
- C2S (NCT06357546)
- Testing
- Spontaneous urination during the hour before caesarean section., Systematic bladder catherization during caesarean section.
- Where
- 2 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Montpellier
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Orthodontic Appliances, Removable, Dental Plaque
Cleaning Methods for Clear Aligners
The goal of this clinical trial is to learn which cleaning method best removes bacteria from clear plastic aligners. Clear aligners are removable orthodontic trays worn to straighten teeth.
- Conditions
- Orthodontic Appliances, Removable, Dental Plaque, Biofilms, Disinfection
- Trial name
- NCT07610603
- Testing
- Toothbrushing of clear aligner with water, Chlorhexidine gluconate 0.2% oral rinse, Effervescent aligner cleaning tablet
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
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