Clinical trials: Randomized-controlled Trial
Interstitial Lung Diseases
FIBRONEER-ACT: A Study to Test Whether Nerandomilast Helps People With Fibrosing Interstitial Lung Disease at Risk for Disease Progression
This study is open to adults with fibrosing interstitial lung disease (ILD) other than idiopathic pulmonary fibrosis (IPF). People can join the study if they have been diagnosed with this condition within the last 3 years and are…
- Trial name
- NCT07540988
- Testing
- Nerandomilast
- Where
- 162 sites in United States, Argentina and 18 more
- Volunteers
- 466 people
- Sponsor
- Boehringer Ingelheim
Venous Thromboembolism, Traumatic Brain Injury
Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Brain injured patients are at high risk for forming blood clots in the legs and lungs. For non-brain injured trauma patients, we decrease the chances of these blood clots forming by placing the patients on a low dose of the blood…
- Trial name
- DEEP (NCT01014403)
- Testing
- enoxaparin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Vitamin D Deficiency, Critical Illness
Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.
The purpose of the research study is to determine whether a single high dose of vitamin D is helpful in reducing critical illness related complications in intensive care patients who are having sever vitamin D deficiency.
- Trial name
- NCT02868827
- Testing
- Cholecalciferol, Milk (Nestle)
- Where
- Saudi Arabia
- Volunteers
- 127 people
- Sponsor
- King Abdullah Medical City
Thumb Osteoarthritis
NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis
The Researchers are trying to compare two different types of intraarticular injections (injection in the joint) for treating the symptoms of moderate to advanced basilar thumb arthritis.
- Trial name
- NCT05992883
- Testing
- Ketorolac, Triamcinolone
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus, Medication Adherence
STUDIIO-Diabetes Pilot: STUdy of Drug Insurance to Improve Outcomes of Diabetes
Canada is the only country with a universal health insurance system that does not provide coverage for prescription drugs to all residents. One-third of working-age Canadians have no insurance.
- Conditions
- Type 2 Diabetes Mellitus, Medication Adherence, Medication Compliance, Medication Nonadherence
- Trial name
- NCT03804905
- Testing
- No-cost Medications
- Volunteers
- 144 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spinal Cord Injury, Urinary Tract Infections
Adjuntive Probiotic Therapy in Treating Urinary Tract Infections in Spinal Cord Injury
We hypothesize that probiotic Lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (UTI) in spinal cord injured patients, and also increase the time to the next episode of UTI.
- Trial name
- NCT00594594
- Testing
- Probiotic Lactobacillus GR-1 and RC-14
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Asthma.
Effect of Aerobic Training in Moderate or Severe Asthmatic Patients
Exercise training has been proposed as adjunctive therapy in asthma to improve many clinical outcomes; however its effects on bronchial hyperresponsiveness (BHR) and inflammation, characteristic features in asthma, remains poorly…
- Trial name
- ETA1 (NCT02033122)
- Testing
- Aerobic training, Breathing exercise
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Instituto de Investigação em Imunologia
Wrist Injuries, Hand and Upper Limb Trauma
Virtual Reality Therapy for Wrist and Hand Injury Recovery
The goal of this randomized clinical trial is to find out whether an early neuro-functional rehabilitation program using virtual reality and action observation can improve recovery after a traumatic injury of the wrist or hand…
- Conditions
- Wrist Injuries, Hand and Upper Limb Trauma, Muskuloskeletan Pain
- Trial name
- AOT+VR (NCT07408622)
- Testing
- Virtual reality
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Malaga
Pain Related to Local Anesthetic Administration for Nexplanon Placement
Pain Related to Local Anesthetic Administration for Nexplanon Placement
This research study is being conducted to see if using buffered lidocaine for Nexplanon placement decreases pain associated with administering local anesthesia compared to unbuffered lidocaine, which is currently used in clinic.
- Trial name
- NCT07008222
- Testing
- we will prepare 3cc of buffered lidocaine consisting of 2.7cc of 1% lidocaine and 0.3cc of 8.4% sodium bicarbonate, Unbuffered lidocaine
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aging Well
Muscle Quality Index Improvement by Exercise and HMB Oral Supplementation in Older Adults
The aging process is accompanied by a decrease in several biological and physical functions, which have an impact on the perception of well-being and quality of life.
- Trial name
- NCT04734951
- Testing
- Power/resistance exercise program, HMB supplementation
- Volunteers
- 76 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3)
Targeted Rehabilitation Versus Standard Care in Managing Medial Knee Pain and Varus Malalignment: A Randomized Control Trial
Medial knee pain with varus alignment is common in active adults and is associated with increased medial joint loading, cartilage loss, and progression of knee osteoarthritis.
- Trial name
- NCT07410429
- Testing
- Conventional Knee Physical Therapy Program, Targeted Alignment-Focused Exercise Program for Varus Knee
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Urolithiasis
Study of Tomography of Nephrolithiasis Evaluation
This is a multi-center, randomized controlled trial of ultrasonography (ultrasound) compared to computed tomography (CT) for the initial emergency room evaluation of patients with suspected renal colic.
- Trial name
- STONE (NCT01451931)
- Testing
- Point-of-care Ultrasound, Radiology Ultrasound, Radiology CT
- Where
- 15 sites in United States
- Volunteers
- 2,776 people
- Sponsor
- University of California, San Francisco
Cirrhosis, Cirrhosis Advanced
Lung Point of Care Ultrasound to Guide Albumin Administration in Cirrhosis
To guide the administration of intravenous albumin by lung ultrasound in decompensated cirrhosis.
- Conditions
- Cirrhosis, Cirrhosis Advanced, Acute Kidney Injury, Ascites
- Trial name
- POCUS (NCT07072572)
- Testing
- Lower albumin dosage
- Where
- Mexico
- Volunteers
- 72 people
- Sponsor
- Centro Medico Issemym
Postprandial Lipid Metabolism, Type 1 Diabetes (T1D)
The TiMeD-T1D Project
The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes.
- Trial name
- NCT07172672
- Testing
- 400 mL Fresubin Energy Drink and 100 mL heavy cream with the addition of the 18F-FTHA radiotracer
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cesarean Section; Dehiscence, Uterine Bleeding
Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the…
- Conditions
- Cesarean Section; Dehiscence, Uterine Bleeding, Uterus; Scar, Uterus Abnormal
- Trial name
- NCT06308172
- Testing
- Hysterotomy closure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hemorrhoids
Comparison of the Clinical Efficacy and Safety of Endoscopic Superior Rectal Mucosal Ligation and Hemorrhoids Ligation
Endoscopic superior rectal mucosal ligation and hemorrhoids ligation are two types of endoscopic ligation, The aim of this study is to compare the clinical efficacy and safety of these two approaches.If you accept this study,you…
- Trial name
- NCT06649786
- Testing
- Endoscopic superior rectal mucosal ligation, Endoscopic hemorrhoid ligation
- Volunteers
- 96 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Pain After Surgery
A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery
This is a multi-center, randomized, double-blind, double-dummy, placebo/active-controlled study. 200 subjects undergoing abdominal surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718…
- Trial name
- NCT07533786
- Testing
- HSK55718 dose level1, HSK55718 dose level2, HSK55718 dose level 3
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Lymphoblastic Leukemia, Acute, Childhood
N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia
The goal of this clinical trial is to analyze the effect of N-Acetylcysteine administration towards blood oxidant level, transaminase enzyme, and bilirubin level in ALL children who undergo induction phase of chemotherapy.
- Trial name
- NCT05611086
- Testing
- N-Acetylcysteine
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Teny Tjitra Sari
Renal Cell Carcinoma
Endoscopic Robot-Assisted Simple Enucleation Versus Standard Robot-Assisted Partial Nephrectomy in the Treatment of T1 Renal Cell Carcinoma
This is a non-inferiority, randomized controlled trial to compare the peri-operative, renal functional and oncologic outcomes of endoscopic robot-assisted simple enucleation(ERASE) and standard robot-assisted partial…
- Trial name
- NCT03624673
- Testing
- endoscopic robot-assisted simple enucleation, standard robot-assisted partial nephrectomy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
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