Clinical trials: Randomized-controlled Trial
Muscle Injury
Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans
Successful skeletal muscle regeneration depends on a functional pool of muscle stem cells, termed satellite cells (SC). SC are in a quiescent state throughout adulthood, but undergo multiple cycles of proliferation and…
- Trial name
- NCT03754842
- Testing
- Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Orthodontic Appliance Complication
The Effect of Using Mobile Applications for Improving Oral Hygiene
The study aims to investigate the effect of the use of mobile phone application sending reminders to patients with orthodontic fixed appliances on oral hygiene.
- Trial name
- NCT03109769
- Testing
- Mobile phone application, Verbal oral hygiene instructions
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies
The purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than Placebo alone
- Trial name
- NCT00824473
- Testing
- 0.15% azelastine hydrochloride
- Where
- 7 sites in United States
- Volunteers
- 506 people
- Sponsor
- Meda Pharmaceuticals
Neoplasms, Breast Neoplasms
Rehabilitation of Cancer Survivors in Denmark: The Effect of a Psychosocial Rehabilitation Course
This randomized study evaluates the effect of a multi-focused, psychosocial 6-day residential rehabilitation course at a Danish rehabilitation centre for cancer survivors.
- Conditions
- Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Prostatic Neoplasms
- Trial name
- NCT01086683
- Testing
- Psychosocial rehabilitation course
- Where
- Denmark
- Volunteers
- 513 people
- Sponsor
- Danish Cancer Society
Septic Shock, Sepsis
Vitamin C and Septic Shock
This is a randomized, double-blind, placebo-controlled clinical trial to compare Vitamin C versus placebo for patients presenting to the ICU with a diagnosis of septic shock.
- Trial name
- NCT03338569
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Interventional Study
Physiological Responses in Robotic Neurorehabilitation
Robotic rehabilitation is very useful for improving functional recovery in neurological patients, there is not much evidence on its role in improving physiological responses (i.e.
- Trial name
- Lokophysio (NCT04035122)
- Testing
- Robotic Treatment, Conventional Treatment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Myeloma, Autologous Transplantation
Long-Term Follow-up Study for Multiple Myeloma Patients Who Received Study Treatment (Plerixafor or Placebo) in the AMD3100-3102 Study (NCT00103662).
This is a long-term observational study of patients that were treated with at least 1 dose of study treatment (plerixafor or placebo) in the AMD3100-3102 protocol (NCT00103662).
- Trial name
- NCT00741780
- Testing
- plerixafor, granulocyte colony-stimulating factor (G-CSF)
- Volunteers
- 164 people
- Sponsor
- Genzyme, a Sanofi Company
Competence, Physical Activity
Physical Literacy-based Intervention for Older Adults
The ageing population creates concerns and challenges worldwide. The large number of older adults (aged over 65) in Hong Kong continues to rise as people live longer.
- Conditions
- Competence, Physical Activity, Knowledge, Attitudes, Practice, Motivation
- Trial name
- NCT06137859
- Testing
- Weekly-based functional fitness training, Mastering Physical Literacy Class, Daily based reflective writing
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Immunogenicity, Efficacy
New Generation mRNA Booster Vaccine Against Emerging VOCs
Primary：Objectives ：SafetyTo describe the safetyprofile of all participants in each group up to 6months post-dose.Immunogenicity：To demonstrate the superiorityof neutralizing antibodyresponse in terms of geometric mean titers…
- Conditions
- Immunogenicity, Efficacy, Safety
- Trial name
- NCT05580159
- Testing
- SW-BIC-213, SARS-Cov-2 Vaccina(Vero Cell ) Inactivated
- Where
- Laos
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Stemirna Therapeutics
Type 2 Diabetes
A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone
The purpose of this clinical research study is to learn whether dapagliflozin can help reduce blood sugar levels in participants with Type 2 diabetes that is not well controlled on metformin alone.
- Trial name
- NCT00528879
- Testing
- Dapagliflozin, Metformin
- Where
- 75 sites in United States, Argentina and 3 more
- Volunteers
- 915 people
- Sponsor
- AstraZeneca
Suicide
Mobile Intervention for Suicidal Thoughts
One of the factors that contributes to suicide risk is what is known as a "suicidal belief system." This belief system is made up of several cognitions that been associated with suicide risk among military personnel.
- Trial name
- NCT06593379
- Testing
- Safety planning, Treatment as usual, MIST Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
HIV Infections
Efficacy of Serious Game Interventions on HCV Education for HIV Patients
Hepatitis C transmission has a high rate of infection and re-infection among PLWH men who have sex with men (MSM), and co-infection increases liver and HIV morbidity.
- Trial name
- NCT05497388
- Testing
- Serious Game
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- National Taiwan University Hospital
Pain, Patient Satisfaction
Patient-controlled Sedation During Repair of Obstetric Perineal Lacerations
The PROP(ofol)-study (EU CT number: 2022-502292-39-00, protocol number: ) is a clinical trial phase IV single centre prospective randomized controlled trial with parallel groups.
- Trial name
- NCT06044103
- Testing
- PDB + PCS
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Marie Blomberg
Urinary Urge Incontinence
Comparison of Combination Therapy vs Single Agent Therapy for Treatment of Urge Incontinence.
This is a randomized double-blind placebo-controlled clinical trial of posterior tibial nerve stimulation (PTNS) plus extended release oxybutynin versus PTNS alone (placebo pills) in women undergoing treatment of urgency urinary…
- Trial name
- APP (NCT02176642)
- Testing
- Oxybutynin extended release, Posterior Tibial Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Duke University
Colorectal Cancer Metastatic
Probiotics as Adjuvant Therapy in the Treatment of Metastatic Colorectal Cancer
The research will be prospective, randomised, placebo controlled and double-blinded.The research will be carried on with regards to Helsinki Declaration and following the guidelines of Good Clinical Practice.
- Trial name
- Probat-tmcc-17 (NCT03705442)
- Testing
- Omni-Biotic 10, loperamide ("Seldiar")
- Where
- Croatia
- Volunteers
- 76 people
- Sponsor
- Marin Golčić
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Fibroid Uterus
Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy
The study team will be randomizing patients presenting for open myomectomy to either received transversus abdominal plane blocks with either liposomal bupivacaine or standard bupivacaine.
- Trial name
- NCT04272086
- Testing
- Bupivacaine, Bupivacaine liposome, normal saline
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Anterior Cruciate Ligament Injuries
Effect of Blood Flow Restriction Technique After Anterior Cruciate Ligament Reconstruction
The purpose of this study will be to evaluate the effect of adding BFR (using 80% of LOP) to the conventional physical therapy program on knee function, functional test, balance, quadriceps and hamstrings muscles strength, thigh…
- Trial name
- NCT06437470
- Testing
- blood flow restriction technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Endometriosis
Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis.
- Trial name
- RELIEF (NCT06974773)
- Testing
- NettleEndo
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Samphire Group, Inc.
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