Clinical trials: Rapid Diagnosis
Depressive Disorder, Major
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide
The purpose of this study is to assess the efficacy of a single (first) dose of 3 fixed doses of intranasal esketamine {28 milligram (mg), 56 mg, and 84 mg} compared with psychoactive placebo (oral midazolam) in rapidly reducing…
- Trial name
- NCT03185819
- Testing
- Midazolam, Esketamine
- Where
- 51 sites in United States, Belgium and 7 more
- Volunteers
- 147 people
- Sponsor
- Janssen Research & Development, LLC
Arterial Occlusive Diseases
Study of Alfimeprase to Rapidly Dissolve Blood Clots in the Leg and Help Prevent the Need for Surgery on Leg Arteries
The purpose of this study is to directly compare the safety and efficacy of intra-thrombus alfimeprase 0.3 mg/kg with placebo in acute peripheral arterial occlusion (PAO) as measured by a 30 day open vascular free surgery rate.
- Trial name
- NCT00115999
- Testing
- alfimeprase
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- ARCA Biopharma, Inc.
Malaria
Getting Malaria "Off the Back" of Women and Children in Western Uganda
This is a two-phase, mixed-methods pilot study of insecticide-treated lesus to reduce the incidence of P. falciparum malaria among infants in a rural area of western Uganda.
- Trial name
- NCT04102592
- Testing
- Permethrin-treated Lesu (baby wrap), Untreated Lesu (baby wrap)
- Where
- Uganda
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension
Improving BP Control in Diverse Populations Using BP MAP
BP-MAP is a cluster randomized controlled trial (RCT) designed to compare the effectiveness of BP lowering from a clinic-based quality improvement program with Full Support (dedicated practice facilitation) vs.
- Trial name
- BP MAP (NCT03818659)
- Testing
- Self-Guided M.A.P. BP Improvement Program, Full Support M.A.P. BP Improvement Program
- Where
- 24 sites in United States
- Volunteers
- 1,238,835 people
- Sponsor
- University of California, San Francisco
COVID-19
You and Me COVID Free
Observational, study that distributes rapid at-home, self-administered, SARS-CoV-2 antigen testing kits to households within pre-selected communities.
- Trial name
- YMCF (NCT05212883)
- Testing
- Behavioral questionaires
- Where
- United States
- Volunteers
- 2,778 people, healthy volunteers welcome
- Sponsor
- Duke University
Lymphoma, Melanoma
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer
Matrix metalloproteinases (MMPs) are a class of membrane bound enzymes that are involved in the degradation of the extracellular matrix. MMP-2 and MMP-9 have been associated with the progression of cancer.
- Conditions
- Lymphoma, Melanoma, Neoplasm Metastasis, Renal Cell Carcinoma
- Trial name
- NCT00001683
- Testing
- COL-3
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Scleroderma, Diffuse
High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis
Systemic sclerosis (scleroderma; SSc) is a rare, disfiguring systemic disorder characterized by fibrosis of the skin and visceral organs that alters every aspect of an individual life Although some features of scleroderma…
- Trial name
- NCT00428883
- Testing
- N-acetylcysteine (NAC)
- Where
- 5 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Università Politecnica delle Marche
Shift Work Schedule, Sleep Deprivation
Quick Returns - Sleep, Cognitive Functions and Individual Differences
The project will contribute with new knowledge concerning how short rest periods between two consecutive shifts (<11h, often defined as a Quick Return (QR)) affects sleep and cognitive performance.
- Trial name
- NCT05162105
- Testing
- Short rest (8 hour) between two consecutive shifts., 16 hour rest opportunity between to consecutive shifts.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Type 1 Diabetes Mellitus
Closed-Loop With Faster Aspart in Young Adults With Type 1 Diabetes
A randomized, double-blinded (for insulin type), single centre, crossover design young adult study, on 20 subjects with type 1 diabetes (T1D), aged 18 to 25 (inclusive) years, measuring time in glucose values within 3.9 - 10…
- Trial name
- NCT03212950
- Testing
- Fast-CL, Regular-CL
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Covid19
Diagnostic Accuracy of Rapid Antigen Test Based on Anterior Nasal Swab Compared With RT-PCR for SARS-CoV-2 Detection.
The aim of this study was to determine the accuracy of anterior nasal swab in rapid antigen (Ag)-tests in a low SARS-CoV-2 prevalence and massive screened community.
- Trial name
- NCT05045846
- Where
- Denmark
- Volunteers
- 3,461 people
- Sponsor
- Christian von Buchwald
Major Depressive Disorder, Alcohol Use Disorder
Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
The investigators will compare 3 treatment groups (ketamine plus naltrexone vs. ketamine alone vs. placebo) for treating major depressive disorder (MDD) and alcohol use disorder (AUD) in an 8-week randomized, double-blind…
- Trial name
- NCT02461927
- Testing
- Ketamine + Naltrexone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Obsessive-Compulsive Disorder
Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders
The goal of this clinical trial is to compare brief-intensive cognitive-behaviour therapy (CBT) with regular weekly CBT in people with anxiety-related disorders.
- Conditions
- Anxiety Disorders, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Hypochondriasis
- Trial name
- KOMMA (NCT05942391)
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 6 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Amsterdam UMC, location VUmc
Cervical Cancer, Uterine Endometrial Cancer
Implementation of a Rapid Recovery Program in Gynecologic Oncology Surgery: A Pilot Study
Over 600,000 hysterectomies are performed annually in the United States. Despite increasing use of less invasive approaches, the majority of hysterectomies are still performed via traditional laparotomy, which can be associated…
- Conditions
- Cervical Cancer, Uterine Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT01705288
- Testing
- Laparotomy, intravenous narcotics, standard anesthesia
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Chronic Periodontitis, Chronic Periodontitis Wth Diabetes Mellitus
Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).
This observational study documents the clinical outcomes of a proprietary, safe-to-swallow metabolic protocol for chronic gum disease.
- Conditions
- Chronic Periodontitis, Chronic Periodontitis Wth Diabetes Mellitus, Non-surgical Periodontal Treatment, Gingival Regeneration
- Trial name
- NCT07538661
- Testing
- Nutraceutical Bio-Active Oral Repair Formula (Food-Grade), Nutraceutical Bio-Active Oral Repair Formula
- Where
- Algeria
- Volunteers
- 20 people
- Sponsor
- Amar h Zireg
Fast Breathing in Young Infants
Community Based Management of Fast Breathing in Infants Aged < 60 Days in Low-income Settlements of Karachi
The aim of the study is to determine optimal management of isolated fast breathing in young infants in a trial design conducted in primary care settings.
- Trial name
- MAT-YI (NCT01533818)
- Testing
- Amoxicillin, Sugar Syrup
- Where
- Pakistan
- Volunteers
- 963 people
- Sponsor
- Aga Khan University
Postpartum Hemorrhage
Does the Rapid Intravenous Administration of Oxytocin After Delivery of the Baby Decrease the Bleeding During Cesarean Section in Women at Risk of Bleeding During Cesarean Section?
Oxytocin is normally given either rapidly into the vein (bolus) or put into an intravenous bag and administered more slowly, after delivery of the baby by cesarean section. Both of these methods are commonly used.
- Trial name
- NCT00257803
- Testing
- Oxytocin, Saline solution
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obesity, Weight Loss
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
This study, involves the implementation and evaluation of a Monday-focused, individually tailored mobile health application to assist overweight or obese adults who would like to achieve a healthful weight.
- Conditions
- Obesity, Weight Loss, mHealth, Healthy Diet
- Trial name
- M-TRIMM2 (NCT04506996)
- Testing
- Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management, Monday-Focused Written Messages for Weight Management, Educational Materials
- Volunteers
- 154 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Sepsis, Emergencies
Triage Score VS Quick-Sofa Score in Septic Patients in the Emergency Department
Sepsis represents by its frequency, its morbidity and mortality and its cost to society a major public health issue with a constantly increasing incidence.
- Trial name
- Triage (NCT04913246)
- Volunteers
- 430 people
- Sponsor
- Hôpital Universitaire Sahloul
Hypersensitivity, Coronary Artery Disease
Physiopathology of Rapid Aspirin Desensitization
Aspirin is very effective in protecting patients with coronary artery disease against adverse cardiac events, because it is a potent "antiplatelet agent".
- Trial name
- NCT01118546
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Keloid Scar
Proof of Concept (POC) Study of the Soliton's Acoustic Scar Reduction (ASR) Treatment for the Treatment of Keloid Scar
To evaluate the safety, and efficacy of the ASR device for the temporary improvement in the appearance of a keloids.
- Trial name
- ASR (NCT04016610)
- Testing
- Soliton's Acoustic Scar Reduction (SAR)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Soliton
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