Clinical trials: Rapid Sequence Intubation
Rapid Sequence Intubation
Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study
There is a great heterogeneity in the practice of rapid sequence induction in the operating room in the world. There are no recent data assessing the rate of implementation of the latest French formalized expert recommendations…
- Trial name
- CoC (NCT06194058)
- Testing
- rapid sequence anesthetic induction
- Where
- 42 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Nantes University Hospital
Airway Control
Observational Study of Rapid Sequence Intubation Drug Delivery Using Intraosseous and Intravenous Access.
This study will evaluate using intraosseous vascular access and intravenous vascular access to give patients the necessary medications to perform rapid sequence intubation, for patients with airway difficulties.
- Trial name
- NCT01486407
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vidacare Corporation
Emergency
Rapid Sequence Intubation at the Emergency Department
All patients undergoing emergent endotracheal intubation (RSI) at the Emergency Department will be screened for inclusion in this clinical study.
- Trial name
- NCT02297113
- Testing
- Macintosh blade, C-MAC videolaryngoscope
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Delayed Sequence Intubation, Rapid Sequence Induction and Intubation
Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols
This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting.
- Conditions
- Delayed Sequence Intubation, Rapid Sequence Induction and Intubation, Intubation, Intubation Complications
- Trial name
- DSI vs RSI (NCT07380763)
- Testing
- Delayed Sequence Intubation, Rapid Sequence Intubation
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Acute Respiratory Failure
Drug Order for Rapid Sequence Intubation
This is a randomized, blinded trial comparing the order of drug administration for rapid sequence intubation in the Emergency Department.
- Trial name
- DO-RSI (NCT03420950)
- Testing
- Rapid sequence intubation: sedative first, Rapid sequence intubation: paralytic first
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- Hennepin Healthcare Research Institute
Critical Illness
Assessment of Hemodynamic Responses at Adequate Depth of Anesthesia Using Bispectral Index During Rapid Sequence Intubation in the Emergency Department
Rapid sequence intubation (RSI) is the standard approach for emergency airway management in critically ill patients requiring endotracheal intubation.
- Trial name
- NCT07722897
- Testing
- Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Akdeniz University Hospital
Hemodynamic Instability During Anesthesia, Induction Anesthesia
Low-dose Propofol Plus High-dose Alfentanil in Rapid Sequence Induction
This study compares four different anesthesia induction regimens to see which one provides the most stable blood pressure and heart rate during rapid sequence intubation.
- Conditions
- Hemodynamic Instability During Anesthesia, Induction Anesthesia, Intubation
- Trial name
- NCT07730918
- Testing
- propofol, alfentanil, Sufentanil
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Aoyang Hospital Affiliated to Jiangsu University
Anesthesia Intubation Complication
Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach
Induction of anesthesia: After 3 minutes pre-oxygenation with 100% oxygen, a blinded dose alfentanil (0,10,20,30,40,50 or 60 µg/kg, followed by thiopental 4 mg/kg and rocuronium 0.6 mg/kg will be administered over 15 sec.
- Trial name
- NCT01518608
- Testing
- Alfentanil 0.5mg/ml (Rapifen , Janssen-Cilag)
- Where
- 2 sites in Norway
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Emergency Airway Management
Bispectral Index and First-Pass Intubation
This prospective observational study aims to evaluate the association between anesthetic depth, measured by the Bispectral Index (BIS), and first-pass endotracheal intubation success in adult patients undergoing rapid sequence…
- Trial name
- NCT07690254
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Akdeniz University Hospital
Intubating Condition
Comparison of Methods to Facilitate Rapid Sequence Intubation
In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.
- Trial name
- NCT01479751
- Testing
- Magnesium Sulfate, Ketamine, rocuronium
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Bundang Hospital
Intubation Complication
Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation
The purpose of this study is to compare the hemodynamic effects of ketamine v etomidate during rapid sequence intubation (RSI) in the pre-hospital and emergency department setting.
- Trial name
- Ket-RSI (NCT03545503)
- Testing
- Etomidate, Ketamine
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- South East Area Health Education Center, Wilmington, NC
Trauma Patients
Commonly Used Drug Regimens for Rapid Sequence Intubation (RSI) of Trauma Patients in the Emergency Department
Airway is the first step in the initial assessment of a trauma patient. Often this assessment determines the need for endotracheal intubation, most commonly by rapid sequence intubation (RSI).
- Trial name
- NCT05243420
- Sponsor
- Methodist Health System
Pyloric Stenosis, Intubation, Pediatric
Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy
The purpose of this study is to compare two different ways of placing breathing tubes for surgery. Both ways are used currently to place breathing tubes and are safe and effective.
- Trial name
- NCT02775214
- Testing
- Video Laryngoscopy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Non-fasting Patients, Rapid Sequence Intubation
Preoperative Presence of Gastric Content in Non-fasting Patients - an Ultrasound Study
Using bedside ultrasound, the investigators will examine gastric content in non-fasting patients assigned to rapid sequence intubation (RSI). The procedure will be done immediately before intubation.
- Conditions
- Non-fasting Patients, Rapid Sequence Intubation, Anesthesia Intubation Complication
- Trial name
- NCT03685435
- Testing
- Bedside ultrasound
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Acute Respiratory Failure
Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients
Rapid-sequence intubation is routinely performed in critically ill patients. It is unclear whether different sedative agents may influence short-term outcomes after intubation, specially hemodynamic stability.
- Trial name
- PROMINE (NCT05092152)
- Testing
- Esketamine, Propofol
- Where
- Brazil
- Volunteers
- 207 people
- Sponsor
- Federal University of São Paulo
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Intubation Conditions
Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study
Magnesium accelerates the reaction of rocuronium, a neuromuscular blocker used for muscle relaxation to ease the intubation during anaesthesia. Succinylcholine is a very fast reacting neuromuscular blocker.
- Trial name
- MagInRoc (NCT01571908)
- Testing
- Magnesium perfusion, Rocuronium, Succinylcholine
- Where
- 2 sites in Switzerland
- Volunteers
- 280 people
- Sponsor
- University Hospital, Geneva
General Surgery
Evaluation of Apnea Tolerance in Bariatric Patients Following Rapid-sequence Induction of Anesthesia
The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apneic time (TAT) in bariatric patients scheduled for laparoscopic adjustable gastric band surgery…
- Trial name
- NCT03056807
- Testing
- 25° head-up position, 55° head-up position
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Kansas Medical Center
Trauma, Rapid Sequence Intubation
Prospective Study of Induction Medications Used in the Trauma RSI
To compare the outcomes of the use of propofol, etomidate, and ketamine as induction agents for adult trauma patients undergoing intubation within 24 hours of admission.
- Trial name
- ProTIM (NCT04291521)
- Testing
- Ketamine, Etomidate, Propofol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Intubation, Intratracheal, Laryngoscopes
The Clarus Video System and Direct Laryngoscope for Rapid Sequence Induction Intubation With Cricoid Pressure
During an emergency endotracheal intubation, rapid sequence induction intubation with cricoid pressure is frequently implemented to prevent aspiration pneumonia.
- Conditions
- Intubation, Intratracheal, Laryngoscopes, Anesthesia, General
- Trial name
- NCT03841890
- Testing
- the Clarus Video System as a video stylet, the Clarus Video System as a lightwand, direct laryngoscope
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital