Clinical trials: Reaching
Hepatocellular Carcinoma
A Study of Ramucirumab (IMC-1121B) Drug Product (DP) and Best Supportive Care (BSC) Versus Placebo and BSC as 2nd-Line Treatment in Participants With Hepatocellular Carcinoma After 1st-Line Therapy With Sorafenib
This is a Phase 3 multicenter, randomized study evaluating the safety and efficacy of ramucirumab DP plus BSC as a double-blind, placebo-controlled (placebo plus BSC) comparison.
- Trial name
- REACH (NCT01140347)
- Testing
- Ramucirumab DP (IMC-1121B), BSC
- Where
- 146 sites in United States, Australia and 25 more
- Volunteers
- 565 people
- Sponsor
- Eli Lilly and Company
Condomless Sex, Human Immunodeficiency Virus (HIV)
Cape Town Young Women's Health CoOp
This two-arm cluster randomized trial tested a gender-focused comprehensive HIV testing and counselling (HTC) program, the Young Women's Health CoOp (YWHC) with a standard HTC program and targeted female adolescents (aged 16-19)…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug Use
- Trial name
- NCT02974998
- Testing
- Young Women's Health CoOp (YWHC), Standard HTC
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RTI International
Hyperphosphataemia, ESRD
Non-interventional Study to Evaluate the Ease of Reaching Individual Goals in Serum Phosphorus (Steering)
The objective of this non-interventional study is to confirm that with standard OsvaRen® treatment it is possible to achieve in at least 60% of the patients the levels of phosphorus, total calcium, and iPTH seen in the CALMAG…
- Trial name
- Steering (NCT01424787)
- Where
- 24 sites in Denmark, Germany and 2 more
- Volunteers
- 324 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Saccadic Eye-Movement Exercise and Physical Performance, Physical Flexibility
Acute Effects of Saccadic Eye-Movement Exercise on Flexibility and Handgrip Strength
This randomized controlled trial investigated whether a short session of saccadic eye-movement exercises could produce immediate changes in flexibility and handgrip strength in healthy adults.
- Conditions
- Saccadic Eye-Movement Exercise and Physical Performance, Physical Flexibility, Handgrip Strength
- Trial name
- NCT07853521
- Testing
- Four-Phase Saccadic Eye-Movement Exercise Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
HNSCC
Randomized Trial of Avelumab-cetuximab-radiotherapy Versus SOCs in LA SCCHN (REACH)
The purpose of this study is to demonstrate that treatment with avelumab in combination with RT-cetuximab is superior to standard of care (SOC) cisplatin-RT and/or to SOC RT-cetuximab alone in terms of progression-free survival…
- Trial name
- REACH (NCT02999087)
- Testing
- Cetuximab, avelumab, Cisplatin
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
HIV Infections
The Test-to-PrEP Study
To compare the effectiveness of two social network strategies (direct distribution and referral-based distribution) in increasing HIV self-testing (HIVST) completion rates among social network contacts of current Pre-Exposure…
- Trial name
- NCT06927856
- Testing
- Test-to-PrEP, Access by Referral
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tetraplegia C5-C6, Tetraplegia C6-C7
Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia
Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach.
- Trial name
- NCT02860403
- Testing
- motor imagery
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Inflammatory Myopathy, Idiopathic, Dermatomyositis
Add-on Intravenous Immunoglobulins in Early Myositis
In patients with myositis early immunomodulation by intensive treatment ("hit-early/hit-hard" principle) may induce faster reduction of disease activity and prevent chronic disability.
- Conditions
- Inflammatory Myopathy, Idiopathic, Dermatomyositis, Antisynthetase Syndrome, Immune-Mediated Necrotizing Myopathy
- Trial name
- TIMEISMUSCLE (NCT05832034)
- Testing
- Immune Globulin Intravenous (Human)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adolescent Drinking, Adolescent Substance Use
Optimizing and Advancing SBIRT in Schools
The goal of this clinical trial is to establish whether brief interventions for alcohol use can be delivered in schools for both indicated prevention and selected prevention, determine if an expanded workforce is an effective…
- Conditions
- Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
- Trial name
- OASIS (NCT06206161)
- Testing
- Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
- Where
- United States
- Volunteers
- 21,000 people
- Sponsor
- Massachusetts General Hospital
Heterozygous Familial Hypercholesterolemia (HeFH), Homozygous Familial Hypercholesterolemia (HoFH)
The ORIGIN-FH Study
The goal of this clinical trial is to identify different types of Familial Hypercholesterolemia (FH) in infants and newborns. Participants will: undergo a cheek swab for genetic testing (parents only) have 5 blood samples…
- Conditions
- Heterozygous Familial Hypercholesterolemia (HeFH), Homozygous Familial Hypercholesterolemia (HoFH), Familial Hypercholesterolemia
- Trial name
- ORIGIN-FH (NCT07470723)
- Testing
- Screening for FH
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Wisconsin, Madison
HIV Infections
Evaluation of an HIV Outreach Program
This study evaluates outreach to HIV-infected people living in unstable housing in New York City who are new to CitiWide Harm Reduction.
- Trial name
- NCT00300183
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Montefiore Medical Center
Attention Deficit Hyperactivity Disorder
Mobile Behavioral Parent Training for Childhood ADHD: Pilot Trial
The goal of the study is to develop and pilot a personalized behavioral parent training intervention for caregivers of children with attention deficit hyperactivity disorder.
- Trial name
- NCT05955274
- Testing
- Mobile Behavioral Parent Training (mBPT), Just-in-time intervention: Parenting Strategies
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Florida International University
Hiv, Violence
Within My Reach (WMR) Adaptation
The purpose of this study is to adapt a relationship education program. The research team is adapting so that it is helpful for Latino sexual minority men.
- Trial name
- NCT06056661
- Testing
- WMR
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Miami
Patient-centered Care
Provider Skill Building for Engagement and Communication in Healthcare - Hypertension Management
Brief Summary: The study has three main goals: The first goal is to make a skills training program that improves how doctors talk with, listen to, and work with patients.
- Trial name
- REACH - HTN (NCT07147075)
- Testing
- REACH - Hypertension
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Breast Neoplasms
Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors
This objective of this randomized controlled trial is to conduct a 2x2 test of a lifestyle intervention and metformin (a drug used to treat diabetes) to investigate how these treatments, alone or in combination, affect biomarkers…
- Trial name
- NCT01302379
- Testing
- Metformin, Lifestyle intervention, Standard printed dietary guidelines
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- University of California, San Diego
Postpartum Hemorrhage
Celox™ PPH for Reaching Haemostasis in Patients With Postpartum Hemorrhage
This is a post market prospective, single arm clinical investigation to continuously assess the safety performance and effectiveness of the Celox™ PPH as a uterine haemostatic tamponade treatment for uterine postpartum hemorrhage…
- Trial name
- NCT06033170
- Testing
- CELOX™ PPH
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Medtrade
Stroke, Upper Extremity Paresis
Cortical Enhancement of Posture, Movement Planning, and Execution of Upright Reaching Following Stroke
Stroke is the leading cause of disability and diminished quality of living that frequently includes impairments of postural control and upper extremity (UE) function.
- Trial name
- NCT04308629
- Testing
- Transcranial direct current stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Obesity, Type 2 Diabetes
REACH-OUT: Chicago Children's Diabetes Prevention Program
The purpose of this research study is to evaluate two nutrition and exercise programs in children ages 9-12 who are at risk for developing type 2 diabetes.
- Trial name
- REACH-OUT (NCT00723853)
- Testing
- Reach-Out Program, nutritional and exercise program, Reach-In Program, standard of care
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Chicago
Body Weight Changes
REseArCH INteGration in Women, Infants, and Children
WIC is a governmental program that provides healthy foods, nutrition education and referrals to other health and social services.
- Trial name
- NCT02657577
- Testing
- There is no intervention
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus, Type 2
Assessment of Insulin Glargine in Type 2 Patients for Good Glycemic Control
Primary objective: To observe the efficacy of the forced titration to reach good glycemic control in Lantus treated patients Secondary objectives: To assess the forced titration on physician and patient satisfaction To evaluate…
- Trial name
- LANTIT (NCT00701831)
- Testing
- Insulin glargine
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Sanofi