Clinical trials: Reactions Adverse
Anesthesia, Anesthesia; Adverse Effect
EEG-guided Propofol Sedation Versus Standard Care for Oesophagogastroduodenoscopy and Colonoscopy in Children
The goal of this clinical trial is to compare electroencephalogram (EEG) guided propofol sedation versus standard care in paediatric patients aged 6-16 undergoing oesophagogastroduodenoscopy and colonoscopy.
- Conditions
- Anesthesia, Anesthesia; Adverse Effect, Anesthesia Emergence Delirium, Sedation Complication
- Trial name
- EPOC (NCT06225037)
- Testing
- Sedline EEG monitoring, Sedline EEG with output concealed
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- KK Women's and Children's Hospital
Leukemia, Hodgkin Disease
Atorvaststin and Cardiotoxicity in Acute Myloid Leukemia
The research proposal focuses on evaluating the efficacy of atorvastatin in reducing cardiotoxicity caused by anthracycline chemotherapy in patients with hematologic malignancies, specifically acute myeloid leukemia (AML) and…
- Trial name
- NCT06684509
- Testing
- Atrovastain
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Pregnancy Related, Cesarean Section; Complications
Haemodynamic Effects of Oxytocin and Carbetocin
The purpose of this study is to evaluate the immediate effects of carbetocin and oxytocin on maternal hemodynamic parameters (heart rate and blood pressure) in a non-invasive setup (TaskeForce®-Monitor) during primary Caesarean…
- Conditions
- Pregnancy Related, Cesarean Section; Complications, Adverse Reaction to Oxytocic Agents
- Trial name
- NCT01277978
- Where
- Austria
- Volunteers
- 84 people
- Sponsor
- Medical University of Graz
Tonsillectomy, Adenoidectomy
Effect of Intranasal Midazolam Versus Ketamine Midazolam Combination as a Premedication on the Occurrence of Postoperative Respiratory Adverse Events
The aim of this study is to investigate the effect of addition of intranasal ketamine to midazolam compared to midazolam alone as a premedication on the occurrence of PRAEs
- Conditions
- Tonsillectomy, Adenoidectomy, Drug-Related Side Effects and Adverse Reaction
- Trial name
- NCT06122948
- Testing
- The midazolam group, The midazolam ketamine group
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kasr El Aini Hospital
Dyskinesia, Drug-Induced, Parkinson Disease
Investigating the Causal Role of preSMA in Levodopa-induced Dyskinesia in Parkinson's Disease
Using a within-subject cross-over design, we will include 20 patients with Parkinson disease (PD) and peak-of-dose dyskinesia. Patients will be studied after withdrawal from their normal dopaminergic medication.
- Trial name
- NCT03354455
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Statin Adverse Reaction
MUscle Side-Effects of Atorvastatin in Coronary Patients (MUSE) -Follow-up Study
Statins are cornerstone treatment in secondary cardiovascular disease (CVD) prevention. Today, statin non-adherence (patients not taking their prescribed drug) remains a major public health concern, leading to adverse outcomes in…
- Trial name
- NCT04453735
- Testing
- Atorvastatin mylan 40 Mg Oral Tablet
- Where
- 2 sites in Norway
- Volunteers
- 27 people
- Sponsor
- Vestre Viken Hospital Trust
Human Papillomavirus Vaccines, Efficacy, Self
A Multicenter Cohort Study Assessing the Efficacy and Adverse Effects of HPV Vaccination in Chinese Women
Human papillomavirus (HPV) is currently one of the most common sexually transmitted infections, according to its carcinogenicity is divided into high-risk genotypes and low-risk genotypes, research has confirmed that carcinogenic…
- Conditions
- Human Papillomavirus Vaccines, Efficacy, Self, Adverse Effect, China
- Trial name
- NCT05932576
- Where
- 5 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Oncology, Autoimmunity
Rheumatologic Adverse Events and Cancer Immunotherapy
In this study, every patient with cancer who is going to be treated by immunotherapy will fill in a form. In this form, we try to determine if he presents rheumatologic complications of his immunotherapy.
- Conditions
- Oncology, Autoimmunity, Arthritis, Adverse Drug Event
- Trial name
- NCT04791150
- Testing
- Fill in a form
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Poitiers University Hospital
Vasopressor Adverse Reaction, Pressure Injury
The Effect of Vasopressor on Pressure Injury Development
Background: Vasopressors are life-saving agents that increase mean arterial pressure. The pharmacodynamic features of these agents and previous studies suggest that vasopressors may be an essential risk factor in developing…
- Conditions
- Vasopressor Adverse Reaction, Pressure Injury, Pressure Ulcer
- Trial name
- NCT06163352
- Testing
- Norepinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Koç University
Arrhythmias, Cardiac, Atrial Fibrillation and Flutter
cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study
Abiraterone associated with prednisone is used in prostate cancer. Abiraterone is a selective small-molecule inhibiting cytochrome P450 17A1 (CYP17A1), a key enzyme in androgen synthesis.
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation and Flutter, Tachycardia, Supraventricular, Cardiac Failure
- Trial name
- ARBITRAGE (NCT03243604)
- Testing
- L02 (sex hormones used in treatment of neoplastic diseases) and G03 (sex hormones)
- Where
- France
- Volunteers
- 1,717 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Cardiac Toxicity, Antitumor Drugs
Risk Assessment Model of Trastuzumab-related Cardiotoxicity in Breast Cancer Patients
According to the existing clinical data in our hospital, retrospective study was conducted to screen the risk factors with predictive value for TRC(trastuzumab-related cardiotoxicity) risk, and to construct the risk prediction…
- Conditions
- Cardiac Toxicity, Antitumor Drugs, Breast Cancer
- Trial name
- NCT04962425
- Testing
- Trastuzumab
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University Third Hospital
Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer
ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up
The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
- Conditions
- Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer, Breast Cancer
- Trial name
- ANTIOX-10 (NCT07680855)
- Volunteers
- 17 people
- Sponsor
- University of Chile
Drug Toxicity
Cytokines Polymorphisms and Acetaminophen Toxicity
Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity following overdose.
- Trial name
- NCT00166608
- Testing
- Blood sampling
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Carcinoid Syndrome
Pharmacokinetics, Efficacy and Safety of an Octreotide Implant in Patients With Carcinoid Syndrome
Evaluate the pharmacokinetics, safety and efficacy of an octreotide implant for the treatment of the symptoms of carcinoid syndrome.
- Trial name
- NCT00884715
- Testing
- Octreotide
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Penicillin Allergy
Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge
The goal of this clinical trial is to learn about dosing when testing to see if a penicillin allergy label can be removed from adults that had been labeled as "penicillin-allergic" previously.
- Trial name
- NCT06303128
- Testing
- Amoxicillin 250 MG, Amoxicillin 62.5mg, Amoxicillin 187.5mg
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- James Tarbox, MD
Erectile Dysfunction Following Radiation Therapy, Phosphodiesterase Inhibitor Adverse Reaction
A Randomized Trial to Evaluate Efficacy and Safety of Intracavernosal Injection of Platelet-Rich Plasma Versus Phosphodiesterase Type-5 Inhibitors for Treatment of Erectile Dysfunction.
The aim of this study is to evaluate the efficacy and safety of intracavernosal injection of PRP in patients with moderate to severe ED.
- Conditions
- Erectile Dysfunction Following Radiation Therapy, Phosphodiesterase Inhibitor Adverse Reaction, Platelet- Rich Plasma (PRP)
- Trial name
- NCT05787769
- Testing
- P shot arm ( Autologous Platelet Rich Plasma), PDE5i arm
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Mansoura University
Dactinomycin Adverse Reaction, Bone and Joint Infection
Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin
Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria.
- Trial name
- NCT04414137
- Testing
- Description of eosinophilic pneumonia due to daptomycine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Spinal Cord Injuries
Injured Spinal Cord Pressure Evaluation
About a thousand people a year in the United Kingdom survive a spinal cord injury but are left paralysed or wheelchair-bound. The annual cost of care for spinal cord injury victims is more than half a billion pounds.
- Trial name
- ISCoPE (NCT02721615)
- Testing
- Insertion of intra spinal sub dural pressure monitor, Insertion of sub dural microdialysis probe
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- St George's, University of London
Hernia, Anesthetics Adverse Reaction
Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial
This present randomized trial is designed to evaluate the postoperative pain,inflammatory marker, postoperative analgesic medication, length of hospital stay and the modifications of inflammatory mediators in patients undergoing…
- Conditions
- Hernia, Anesthetics Adverse Reaction, Inflammation
- Trial name
- NCT01845376
- Testing
- local anesthesia group, spinal anesthesia group, general anesthesia group
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Mingkwan Wongyingsinn, MD
Cisplatin, Ototoxicity
Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin.
In this study we will aim to determine if cisplatin ototoxicity can be prevented by intratympanic administration of corticosteroids.
- Conditions
- Cisplatin, Ototoxicity, Intratympanic Steroids
- Trial name
- NCT01285674
- Testing
- Intra-tympanic Cisplatinum
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Ziv Hospital
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