Clinical trials: Reconstruction
Pelvic Organ Prolapse
A Multi-center Registry Study: The Follow-up the Complications for Trans-vaginal Mesh Surgery
This is a multi-center, prospective, observational, hospital-based registry of pelvic organ prolapse(POP) patients who having trans-vaginal mesh implantation with 12 month and 36 month follow-up.To investigate the incidence of…
- Trial name
- NCT04025047
- Where
- China
- Volunteers
- 4,147 people
- Sponsor
- Peking Union Medical College Hospital
Other Reconstructive Surgery
Clonidine in Femoral Nerve Block Surgery in Children
Knee arthroscopy is a common surgical procedure in pediatrics in which the knee joint is visualized through a small camera to help diagnose and treat knee problems.
- Trial name
- NCT01293149
- Testing
- Ropivacaine, Clonidine
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Retinal Artery Occlusion
Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion
Retinal artery occlusions (RAO) cause deterioration in visual acuity and visual fields. In computational fluid dynamics (CFD) studies [1] 10% of ascending emboli caused RAO, the residual 90% embolized into the cerebral arteries.
- Trial name
- NCT02679716
- Testing
- MRI of the cerebral arteries
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Vitamin D to Improve Quadricep Muscle Strength
Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle…
- Conditions
- Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05174611
- Testing
- Vitamin D3
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
ACL Tear
Safe Return to Play After ACL Reconstruction
Recent studies report that as few as 44% of athletes undergoing ACL reconstruction were able to return to their prior level of competitive level of sports.
- Trial name
- NCT04827264
- Testing
- Safe Return to Play Following ACL Reconstruction Checklist
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Rothman Institute Orthopaedics
Anterior Cruciate Ligament Injuries, Knee Injuries
Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial
Many patients experience quadriceps inhibition after anterior cruciate ligament (ACL) reconstruction, delaying strength recovery, hindering return to sport, and potentially increasing the risk of re-injury.
- Conditions
- Anterior Cruciate Ligament Injuries, Knee Injuries, Muscle Weakness
- Trial name
- NCT07145606
- Testing
- Standard Rehabilitation, Blood Flow Restriction (BFR) Training, sEMG Biofeedback
- Where
- 4 sites in France, Switzerland
- Volunteers
- 200 people
- Sponsor
- Haute Ecole ARC Sante
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Hypertrophic Scar, Scar
Silicone Taping for the Improvement of Abdominal Donor Site Scars
This study will look at silicone tape compared to the current no dressing standard at the investigators institution, to determine if silicone tape provides a significant improvement in post-abdominoplasty scar appearance.
- Trial name
- NCT04506255
- Testing
- Silicone tape
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Nova Scotia Health Authority
ACL Tear
Augmentation of Anterior Cruciate Ligament Reconstruction Using Mesenchymal Stem Cells and Collagen Matrix Carrier
The goal of this observational study is to compare patient outcomes for reconstructive surgery of ACL tears. This study utilizes two randomized groups, one being the control group that receives standard ACL reconstructive…
- Trial name
- BioACL (NCT05582226)
- Testing
- ACL reconstruction, Mesenchymal stem cell implantation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Andrews Research & Education Foundation
Seroma, Breast Cancer
Seroma of the Mammary Gland
The study is designed as international, prospective, minimal interventional study in cooperation with EUBREAST e.V. (European Breast Cancer Research Association of Surgical Trialists).
- Conditions
- Seroma, Breast Cancer, Mastectomy, Breast Implant; Complications
- Trial name
- SerMa (NCT05899387)
- Testing
- Swap collection, Seroma punction, Blood sampling
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Augsburg
Crestal Bone Loss, Survival Rate
"Bony Changes Around Dental Implant in Free Fibular Graft Versus Non-Vascularized Iliac Crest Graft"
The goal of this clinical trial is to evaluate the bony changes around dental implants in non-vascularized iliac crest grafts and free vascularized fibular flap in mandibular reconstruction.
- Trial name
- NCT06095843
- Testing
- placement of dental implants
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Ain Shams University
Reconstructive Surgery
Retrospective Analysis of Surgical Outcomes in Patients Treated for Gunshot-Related Bone Defects at Mekelle University Hospital
his project looks back at past surgeries performed between 2019 and 2023 in a hospital in Mekelle, Ethiopia. During this time, a team of doctors from Austria and other countries visited the hospital to help patients who had been…
- Trial name
- NCT06935916
- Testing
- pedicled or free tissue transfer
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Julian Joestl
Pain, Postoperative
the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.
Anterior cruciate ligament (ACL) injury is traumatic and debilitating and is typically repaired using an arthroscopic technique performed as an outpatient surgical procedure.
- Trial name
- NCT04020133
- Testing
- saphenous nerve block, popliteal plexus block, Plain bupivacaine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Fayoum University Hospital
Breast Cancer, Breast Reconstruction
Closed Incision Disposable Negative Pressure Wound Therapy in Immediate Postmastectomy Breast Reconstruction
The study aimed to assess the impact of the use of closed incision negative pressure wound therapy (ciNPWT) after immediate breast reconstruction on the number of surgical-site complications, skin surface temperature, objective…
- Trial name
- NCT04808765
- Testing
- Immediate Breast reconstruction
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- University in Zielona Góra
Breast Cancer, Surgery
Evaluation of ADM Soft Tissue Reinforcement
The use of acellular dermal matrix (ADM) has facilitated implant-based breast reconstruction, both in single-stage direct-to-implant (DTI) and staged tissue expander placement.
- Conditions
- Breast Cancer, Surgery, Surgical Item, Retained
- Trial name
- NCT03494244
- Testing
- Direct-to-implant breast reconstruction, Acellular dermal matrix
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Head and Neck Cancer
A 3D Analysis of Mandibular Plating Strategies in Oromandibular Reconstruction.
Reconstruction of the mandible commonly employs the use of metal plates to provide a framework for placement of bone grafts. The standard approach to reconstruction involves bending these plates to the mandible intraoperatively.
- Trial name
- 3Dplating (NCT03550053)
- Testing
- 3D mandibular plate
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
- Conditions
- Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)
- Trial name
- SPY NITROPASTE (NCT07004764)
- Testing
- Nitroglycerin Ointment 2%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Gastric (Cardia, Body) Cancer
Quality of Life After Billroth II or Roux-en-Y for Gastric Cancer
The treatment of a local distal gastric cancer remains surgical before or after chemotherapy. Partial gastrectomy is recommended for distal location cancer The recommendations for restoring continuity are less evident.
- Trial name
- BYQoL-GC (NCT06768164)
- Testing
- Billroth 2 (B2), Roux-En-Y (REY)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Postoperative, Anterior Cruciate Ligament Injuries
IPACK on Early Pain Scores After ACL Reconstruction
The goal of this clinical trial is to learn whether using an anesthetic technique called IPACK block will control pain after ACL reconstruction surgery.
- Conditions
- Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
- Trial name
- NCT05985629
- Testing
- IPACK
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Loyola University
Breast Implant; Complications, Breast Implant Protrusion
Standard Silicone-based vs. B-Lite® Light Weight Breast Implant After Total Mastectomy and Radiotherapy for Breast Cancer
Reconstructive surgery with breast implants after total mastectomy for breast cancer is invariably related to several possible complications, such as atrophy of surrounding tissues, skin thinning, capsular contracture, wound…
- Conditions
- Breast Implant; Complications, Breast Implant Protrusion, Breast Cancer, Radiotherapy Side Effect
- Trial name
- BLITE-01 (NCT03737500)
- Testing
- B-Lite® light weight breast implant, Standard silicone-based breast implant
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA