Clinical trials: Reconstructive Surgery, open to volunteers
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Rotator Cuff
Early Recovery After Surgery (ERAS)/Prehabilitation - Randomized Controlled Trial on the Implementation of ERAS/prehabilitation in Elective Reconstructive Shoulder Surgery
The aim of this randomized controlled trial is to investigate whether the intervention can improve the clinical outcome and patient satisfaction in elective reconstructive shoulder surgeries.
- Trial name
- Prehab (NCT06868472)
- Testing
- Prehabilitation, Control
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Prof. Arasch Wafaisade
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Carcinoma
PARTial BREast RECONstruction With Chest Wall Perforator Flap
The goal of this observational study is to ascertain the outcomes following partial breast reconstruction using chest wall perforator flaps after breast conservation surgery.
- Conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Carcinoma, Breast Neoplasms, Breast Surgery
- Trial name
- PartBreCon (NCT06728527)
- Where
- United Kingdom
- Volunteers
- 1,001 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Breast Cancer
International Prospective REgistry on Pre-pectorAl Breast REconstruction
This is an international multicenter prospective cohort study aimed at collecting data on breast reconstruction techniques with pre-pectoral implants after mastectomy for breast cancer.
- Trial name
- I-PREPARE (NCT05817175)
- Testing
- pre-pectoral breast reconstruction
- Where
- 11 sites in Argentina, Egypt and 7 more
- Volunteers
- 1,236 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Hypertrophic Scar, Scar
Silicone Taping for the Improvement of Abdominal Donor Site Scars
This study will look at silicone tape compared to the current no dressing standard at the investigators institution, to determine if silicone tape provides a significant improvement in post-abdominoplasty scar appearance.
- Trial name
- NCT04506255
- Testing
- Silicone tape
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Nova Scotia Health Authority
Reconstructive Surgical Procedures, Free Tissue Flaps
Energy Expenditure Assessment in Head and Neck Cancer Patients Treated With Free Flap Surgery
What is the purpose of this study? Patients with head and neck cancer who undergo surgery with free flap reconstruction often need careful nutritional support during recovery.
- Conditions
- Reconstructive Surgical Procedures, Free Tissue Flaps, Head and Neck Cancer, Perioperative Care
- Trial name
- NCT07759193
- Testing
- Indirect Calorimetry (Diagnostic Test)
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ankle and Hindfoot Alterations
3D Multisegment Foot Model Used for the Clinical Outcome After Ankle and Hindfoot Reconstruction
Most symptomatic pathologies of the ankle and hindfoot are determined by biomechanical alterations of this anatomical region. Surgical treatment of these pathologies is therefore aimed at improving the inferior biomechanical…
- Trial name
- 3D-MFM (NCT04822558)
- Testing
- Plantar pressure measurement, Gait analysis, Ankle and hindfoot reconstruction surgery
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Abdomen Hernia
The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR
Randomized controlled trial to compare SSO's in abdominal wall reconstruction patients using Prevena, Prineo, and traditional incisional dressings.
- Trial name
- NCT04906408
- Testing
- Prevena, Prineo, Traditional
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Gastric Cancer, Diabetes Mellitus, Type 2
Surgical TreAtment for Obesity Related Disease and Onco-Metabolic Surgery
This is a prospective, multi-center, randomized controlled trial to compare Billroth II reconstruction versus conventional Roux-en-Y reconstruction versus long limb Roux-en-Y reconstruction for glycemic control in patients with…
- Trial name
- STARDOM (NCT04284943)
- Testing
- Long limb Roux-en-Y reconstruction after subtotal gastrectomy, Conventional Roux-en-Y reconstruction after subtotal gastrectomy, Billroth II reconstruction after subtotal gastrectomy
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Korea University Anam Hospital
Breast Cancer, Invasive Breast Cancer
A Study of an Alternative Treatment Approach (Preoperative Radiotherapy, Then Mastectomy, Then Immediate Reconstruction Surgery) in People With T4 Breast Cancer
The purpose of this study to test an alternative treatment approach that involves giving participants radiotherapy before their mastectomy (preoperative radiotherapy) and performing immediate reconstruction surgery at the time of…
- Trial name
- NCT05412225
- Testing
- Pre-neoadjuvant radiotherapy (NART) biopsy, Neoadjuvant radiotherapy, Unilateral total mastectomy with axillary lymph node dissection
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Targeted Nerve Surgery for the Prevention of Post-Mastectomy Pain Syndrome: A Randomized Trial
Post-Mastectomy Pain Syndrome (PMPS) is a chronic pain condition often caused by neuroma formation and nerve injury following breast cancer surgery.
- Trial name
- NCT07146009
- Testing
- Nerve Surgery, Standard of Care (Investigator Choice)
- Volunteers
- 60 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Paramedian Forehead Flap
Topical CBD Scar Healing Study
The purpose of this study is to find out what effects (good and bad) that cannabidiol (CBD) has on scar healing and appearance in patients who have undergone paramedian forehead flap reconstruction.
- Trial name
- NCT06129591
- Testing
- Vantage Hemp CBD Isolate + Silicone patch, Silicone patch
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Oklahoma
Ureteral Stenosis
An Investigation Into the Application of Preputial Grafts for the Reconstruction of Complex Ureteral Strictures
Complex ureteral stricture refers to a ureteral lumen stenosis lesion that cannot be directly treated with the traditional end-to-end anastomosis.
- Trial name
- PGU20240101 (NCT07408050)
- Testing
- Preputial graft ureteroplasty
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruibao chen
Breast Cancer
NeoRad Breast Cancer Study
The NEORAD trial tests whether preoperative radiotherapy results in an improved DFS and less radiation induced late effect compared to postoperative radiotherapy in higher risk breast cancer after NACT.
- Trial name
- NeoRad (NCT04261244)
- Testing
- preoperative radiotherapy, postoperative radiotherapy
- Where
- 16 sites in Germany
- Volunteers
- 1,826 people
- Sponsor
- Bielefeld University
Lymphedema, Lymphedema of Face
Clinical Lymphedema Evaluation - Advancing Reconstruction of Head and Neck Lymphatics With Symani
The objective of this study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during open lymphatic reconstruction in the head and neck.
- Conditions
- Lymphedema, Lymphedema of Face, Internal Lymphedema, External Lymphedema
- Trial name
- CLEAR (NCT07311876)
- Testing
- Symani Surgical System
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- MMI (Medical Microinstruments, Inc.)
ACL Injury, Hemodynamics
A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy
This study aims to establish and compare muscle haemodynamic response patterns in physically active subjects with anterior cruciate ligament (ACL) reconstruction, at different time points after surgery, against healthy controls…
- Conditions
- ACL Injury, Hemodynamics, Oxygen Consumption Based Assessment of Hemodynamics, Exercise
- Trial name
- HemoNIRS-LCA (NCT06621355)
- Testing
- Incremental Interval Test on a Cycle Ergometer
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Complex Limb Bone Deformity, Limb Length Discrepancy
Multistage Additive Manufacturing for Complex Limb Bone Deformity Reconstruction
Complex deformities of the limb bones may involve abnormal angulation, limb or bone shortening, abnormal rotation and structural bone loss.
- Conditions
- Complex Limb Bone Deformity, Limb Length Discrepancy, Angular Deformity, Rotational Deformity
- Trial name
- MAP-BD (NCT07779278)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Alveolar Cleft
Metformin and Alveolar Cleft
Completed medical history will take for all patients. All patients' guardians were informed about the procedure, the possible postoperative complications, and requested to sign an informed consent that was translated into Arabic…
- Trial name
- NCT07536620
- Testing
- metformin group
- Volunteers
- 36 people
- Sponsor
- Fayoum University
Mandibular Reconstruction, Segmental Mandibular Defects
Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection and Drugs-induced Osteonecrosis
Prospective will be collected in a minimum of 300 patients presenting with an acquired segmental mandibular defect ≥ 2 cm secondary to OSSC removal and drugs-induced osteonecrosis, and who require mandibular reconstruction.
- Trial name
- NCT04098146
- Testing
- Surgical Resection and Reconstruction
- Where
- 19 sites in United States, Germany and 6 more
- Volunteers
- 300 people
- Sponsor
- AO Innovation Translation Center