Clinical trials: Reconstructive Surgical Procedure
Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries
Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)
This clinical trial aims to investigate the correlation between psychological readiness, knee function, and isokinetic performance after anterior cruciate ligament reconstruction (ACLR) using the Peroneus Longus tendon graft…
- Conditions
- Anterior Cruciate Ligament (ACL) Injury, Athletic Injuries, Knee Injuries
- Trial name
- PL-ACLR (NCT07201597)
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Sports Physical Therapy
PNF and BFR Affect on Pain, ROM & Functional Outcome in Post-op ACL
A randomized controlled trial investigated the effects of Hold Relax Technique (HRT) with and without Blood Flow Restriction (BFR) on pain, range of motion (ROM), and functional disability in patients with post-operative ACL…
- Trial name
- NCT06943079
- Testing
- Effect of Hold Relax technique with Blood Flow Restriction technique on functional outcome, Effect of Hold Relax technique without Blood Flow Restriction technique on functional outcomes
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Melanoma
Review of the Literature and Serie of Patients Who Underwent Reconstruction After Wide Local Excision of Nail Apparatus for Melanoma
Melanomas of the nail bed are often diagnosed at the locally advanced stage. The standard treatment was amputation of the finger or toe, but it has now been established that enlarged excision of the nail plate is sufficient under…
- Trial name
- NCT06861023
- Testing
- Patients who have undergone extensive nail resection with reconstruction
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Non-Small Cell Lung Cancer
Gut Microbiota Reconstruction for NSCLC Immunotherapy
In this study, patients with locally advanced or metastatic NSCLC after first-line treatment with PD-1/PDL-1 monoclonal antibody will be treated with Gut Microbiota reconstruction(such as FMT) combined with PD-1/PDL-1 monoclonal…
- Trial name
- NCT05008861
- Testing
- Capsulized Fecal Microbiota Transplant, Anti-programmed cell death protein 1/programmed death-ligand 1 monoclonal antibody, Platinum based chemotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Nocturnal Enuresis
Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction
The purpose of this study is to prospectively assess whether Desmopressin, given for a period of month to patients after radical cystectomy with orthotopic bladder reconstruction, improves and lowers the rate of nocturnal…
- Trial name
- NCT01582542
- Testing
- Desmopressin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Breast Cancer Patients Undergoing Mastectomy With Immediate Reconstruction
Ultrasound-guided Erector Spinae Plane Block Versus Paravertebral Block in Breast Cancer Patients Undergoing Mastectomy With Immediate Reconstruction - a Non-inferiority Trial
The objective of this study is to assess the non-inferiority of analgesic efficacy of ESP vs PVB for patients undergoing unilateral mastectomy followed by immediate reconstruction.
- Trial name
- ESP (NCT05590559)
- Testing
- Morphine, Ultrasound-guided erector spinae plane block
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Patellar Dislocation, Recurrent, Patellar Dislocation
JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction
The goal of this observational study is to learn about the outcomes of medial patellofemoral ligament (MPFL) reconstruction for the treatment of recurrent patellar instability.
- Conditions
- Patellar Dislocation, Recurrent, Patellar Dislocation, Patellar Instability, Patellofemoral Dislocation
- Trial name
- NCT06883396
- Testing
- Medial Patellofemoral Ligament (MPFL) Reconstruction
- Where
- 16 sites in United States
- Volunteers
- 850 people
- Sponsor
- Hospital for Special Surgery, New York
Breast Cancer, Frailty
VR for Surgical Prehabilitation and Rehabilitation
This randomized controlled trial aims to determine feasibility and acceptability of of VR-physical therapy modules for surgical patients undergoing breast or axilla surgery in order to prepare for and recover from surgery.
- Conditions
- Breast Cancer, Frailty, Surgery
- Trial name
- VR-PREP (NCT06334380)
- Testing
- Virtual Reality Modules Only, Virtual Reality Modules + Live Physical Therapist Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Skull Base
Bed Rest Duration and Outcomes in Endoscopic Skull Base Reconstruction
This study is a randomized controlled trial conducted across multiple centers. Due to the anatomical and pathological complexity of endoscopic endonasal skull base surgery, the study scope was restricted to the midline anterior…
- Trial name
- BRO (NCT07465861)
- Testing
- non-bed-rest, 2-day bed-rest, 1-day bed-rest
- Volunteers
- 316 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Mastectomy, Breast Reconstruction
Evaluation of a Human Acellular Dermal Matrix in Post Mastectomy Reconstruction
Use of a HADM and implant in post-mastectomy breast reconstruction.
- Trial name
- NCT02263261
- Testing
- Flex HD Pliable Perforated HADM
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Musculoskeletal Transplant Foundation
Anterior Cruciate Ligament Injury
Light Load Blood Flow Restriction Training in Anterior Cruciate Ligament Reconstruction Patient Rehabilitation
This study is examining the post-operative rehabilitation of anterior cruciate ligament (ACL) reconstruction patients within the National Health Service (NHS).
- Trial name
- NCT03419169
- Testing
- Light load BFR resistance training, Heavy load resistance training
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Heart Aneurysm
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance Imaging for the Detection of Intracardiac Thrombus
The incidence of thrombosis in ventricular aneurysm was reported to be 35%-40%, which may lead to systemic thromboembolism. Patients with ventricular aneurysm without detectable thrombus are not routinely treated with…
- Trial name
- NCT06146751
- Testing
- Superparamagnetic Iron Oxide Nanoparticles
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Chest Wall Tumor
Clinical Trial on the Efficacy and Safety of Biodegradable 3D-Printed Implants in Chest Wall Reconstruction Surgery
This project focuses on patients with chest wall tumors who are expected to have a maximum intraoperative anterolateral chest wall defect diameter of 5-10 cm and require chest wall reconstruction with rib implants.
- Trial name
- NCT06977022
- Testing
- Chest wall reconstruction
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tang-Du Hospital
the Posterolateral Structure of the Knee Joint, Arthroscopy
Clinical Study of Posterolateral Structure of Knee Joint Under Arthroscopy
Objective: To study the clinical effect of anatomical reconstruction of the posterolateral structure of the knee joint under arthroscopy.
- Conditions
- the Posterolateral Structure of the Knee Joint, Arthroscopy, Anatomical Reconstruction
- Trial name
- NCT04461431
- Testing
- Arthroscopic anatomical reconstruction of the posterolateral structure of the knee
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
ACL Reconstruction
Psychological and Physiological Parameters for Return-to-sport After ACL Reconstruction
Injuries to the anterior cruciate ligament are common and are usually treated with reconstruction and subsequent rehabilitation. Many people succeed in return to sport (RTS), but not to the original level.
- Trial name
- ACL-RTS (NCT07259083)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Johannes Kepler University of Linz
Reconstructive Surgery, Microcirculation
Microcirculation in Perforator Flaps. Enhancing Tissue Survival
The aim of the present study is to assess the microcirculatory changes in the distal part of the perforator flap using ICG fluorescence angiography.
- Trial name
- NCT01204554
- Testing
- Indocyanine green (ICG)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Urinary Retention Postoperative
Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery
The objective of the study is to determine the effectiveness of postoperative Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) following pelvic reconstructive surgery through a double blind…
- Trial name
- NCT04597372
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Congenital Heart Disease
Cerebral Oximetric Monitoring of the Posterior Circulation
One known risk of pediatric heart surgery is the possibility for brain damage. This problem results from a lack of oxygen rich blood flow to the brain during surgery.
- Trial name
- CerebralOx (NCT00751712)
- Testing
- Cerebral oximeter sensor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Scar
Forehead Scars Following Mohs Micrographic Surgery and Reconstruction for Skin Cancer
This study will test if the use of DysportTM (abobotulinumtoxinA) improves wound healing and scarring after Mohs surgery. Research in the laboratory as well as previous studies in humans have shown improved wound healing and…
- Trial name
- NCT01459666
- Testing
- Dysport (abobotulinumtoxinA), Bacteriostatic 0.9% Sodium Chloride (vehicle)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University Hospitals Cleveland Medical Center
Blow-Out Fractures, Orbital Fractures
Accuracy& Orbital Volume Using Patient Specific Titanium Implant Vs Zirconia for Orbital Floor Reconstruction
Comparative study used to assess if the patient specific zirconia implant will provide better accuracy, intraoperative adaptability, precise orbital volume and soft tissue reaction with more cost effectiveness than the patient…
- Conditions
- Blow-Out Fractures, Orbital Fractures, Orbital Floor Fracture, Orbital Trauma
- Trial name
- NCT06369129
- Testing
- Orbital floor reconstruction with Patient Specific Zirconia Implant, Orbital floor reconstruction with Patient Specific Titanium Implant
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University