Clinical trials: Recovery, open to volunteers
Hepatic Ischemia
Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy
Compared the effects of Sodium bicarbonate Ringer's solution and lactate Ringer's solution on the internal environment and hemodynamics of patients during laparoscopic liver resection, to observe the application prospect of…
- Trial name
- NCT05830136
- Testing
- sodium bicarbonate Ringer's solution
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Pain
Evaluation of Pain Treatment After Total Knee Arthroplasty
The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).
- Trial name
- NCT07538570
- Testing
- Suzetrigine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Heart Failure
The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
Heart failure (HF) is a chronic condition that is characterized by a weakened and enlarged heart. It typically causes symptoms such as breathlessness and swelling of the legs, and it is a serious illness that shortens life…
- Trial name
- TAPERED-HF (NCT07513883)
- Testing
- Down-titration, Continuation of guideline-directed heart failure therapy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg
Repetitive Transcranial Magnetic Stimulation, Stroke
Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological
To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Stroke, Functional MRI
- Trial name
- NCT06799312
- Testing
- Ipsilesional high frequency rTMS combined with physiotherapy, Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Assiut University
Gynecologic Cancer, Anemia
Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery)
Iron deficiency has been reported in approximately 35% of patients with a gynecologic malignancy. Blood transfusions are known to be immunosuppressive and carry immediate and long-term risks.
- Conditions
- Gynecologic Cancer, Anemia, Iron-deficiency
- Trial name
- FORGE II (NCT05407987)
- Testing
- Ferric derisomaltose
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- AHS Cancer Control Alberta
Cubital Tunnel Syndrome, Electrical Stimulation
Conditioning Electrical Stimulation to Improve Outcomes in Cubital Tunnel Syndrome
Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor.
- Trial name
- NCT05395715
- Testing
- Electrical stimulation
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Carpal Tunnel Surgery, Trigger Finger Disorder
NAC-REPAIR for Post-surgical Pain
This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating…
- Conditions
- Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal
- Trial name
- NCT07227649
- Testing
- NAC
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Arizona
Prostate Cancer
Early Salvage Therapy for Patients With Advanced Features for Biochemical Relapse After Radical Prostatectomy for Localized Prostate Carcinoma In Correlation With Supposed Molecular-genetic Parameters of Higher Aggressiveness
The primary objective of the trial is to compare the impact and safety of delayed salvage therapy (dSRT, i.e., SRT initiated at PSA values of 0.4-0.5 ng/ml) to those of early salvage therapy (eSRT, i.e., at PSA levels of 0.2…
- Trial name
- ESTABLISH (NCT05232578)
- Testing
- Early salvage radiotherapy (eSRT), Delayed Salvage radiotherapy (dSRT)
- Volunteers
- 380 people
- Sponsor
- General University Hospital, Prague
Total Knee Arthroplasty Recovery, Knee Osteoarthritis
Wearable Knee-Assisted Rehabilitation for Range of Motion and Muscle Strength After Total Knee Arthroplasty
This randomized controlled trial evaluates a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07875725
- Testing
- ReBK Wearable Telerehabilitation System, Standard Home-Based Rehabilitation
- Where
- 3 sites in Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Postoperative Pain, Postoperative Complications
Protocol for Accelerated Recovery in Patients Undergoing Thoracic Surgical Procedures (PROSM). Study Randomized Comparative Between the Adoption of the Proposed Guidelines and the Traditional Method Currently Used in the Institution
Introduction: Aiming at reducing costs and optimizing the use of these financial resources, several postoperative recovery protocols have emerged that aim to reduce the length of hospital stay by accelerating surgical…
- Conditions
- Postoperative Pain, Postoperative Complications, Postoperative Nausea, Lung Cancer
- Trial name
- PROSM (NCT03271749)
- Testing
- PROSM guidelines for preoperative, anesthesia and postoperative care for lung resections
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Igor Renato Louro Bruno de Abreu
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cardiac Surgery Recovery, Inflammation
Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries
This prospective single-center randomized controlled trial aims at evaluating the safety and feasibility of an hemoadsorption protocol using Jafron HA-60 during cardio-pulmonary bypass in 20 pediatric patients undergoing…
- Conditions
- Cardiac Surgery Recovery, Inflammation, Complex Cardiovascular Surgery With Cardiopulmonary Bypass, Cytokine Storm
- Trial name
- JACKPOT (NCT07393087)
- Testing
- Hemoadsorption
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cerebral Vascular Accident (CVA)/Stroke
The Natural History of Recovery After Stroke
The goal of this longitudinal observational study is to learn the course of recovery after stroke. Specifically, in this study we will learn and describe the changes in cognitive, motor and sensory function over time in stroke…
- Trial name
- RESTRO (NCT06441552)
- Testing
- non-interventional
- Where
- 3 sites in Israel, Palestinian Territories
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Adi Negev-Nahalat Eran
Pulmonary Nodule, Pneumothorax
Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection
Brief Summary The goal of this clinical trial is to evaluate the safety and recovery outcomes of different tubeless strategies in adult patients undergoing uniportal video-assisted thoracoscopic (VATS) wedge resection who are…
- Conditions
- Pulmonary Nodule, Pneumothorax, Postoperative Complications
- Trial name
- NCT07395349
- Testing
- Conventional Chest Tube Drainage, Single Intraoperative Aspiration Tubeless, Double Intraoperative Aspiration Tubeless
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Perinatal Spinal Cord Injury
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination…
- Trial name
- NCT06808035
- Testing
- Activity-Based Recovery Training, Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Louisville
Joint (Knee or Hip Replacement)
The Impact of Extending Sleep Before Joint-replacement Surgery on Post-surgical Pain
This study will evaluate the impact of sleep banking on joint replacement surgery recovery.
- Trial name
- NCT07383584
- Testing
- Sleep banking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Gynecologic Surgery, General Anesthesia
Long-term Follow-up of Bio-signals and Quality of Recovery Following Implementation of ERAS Based on the Mobile Application
The goal of this clinical trial is to evaluate the effect of an Enhanced Recovery After Surgery (ERAS) protocol in patients undergoing gynecologic laparoscopic or robotic surgery under general anesthesia.
- Trial name
- NCT07868952
- Testing
- Enhanced Recovery After Surgery, Usual Care
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Wonju Severance Christian Hospital
Exercise Recovery
Human TECAR on Exercise Preconditioning and Post-exercise Recovery
TECAR therapy (Transfer of Energy Capacitive and Resistive) is a type of diathermy that uses radiant energy to generate endogenous heat.
- Trial name
- NCT06938984
- Testing
- Capacitive mode before, Resistive mode before, Capacitive mode after
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Breast Cancer Survivorship, Breast Cancer
Development and Validation of a Personalized Digital Healthcare Model for Managing Side Effects in Breast Cancer Survivors
The ultimate goal of this research and development is to develop personalized digital healthcare technologies and self-management strategies based on self-assessment results and evidence, for breast cancer survivors who require…
- Conditions
- Breast Cancer Survivorship, Breast Cancer, Digital Health
- Trial name
- NCT06729684
- Testing
- digital health (application and smartwatch)
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
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