Clinical trials: Rectal Adenoma
Colorectal Cancer, Adenoma Colon
Characterization of Brazilian Colorectal Cancer Screening Population
Colorectal cancer (CRC) is the third most common type of cancer among men and the second among women in Brazil. Despite the high incidence and significance of CRC in Brazil, very little is known about its prevalence among the…
- Trial name
- NCT03355391
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Solid Tumors (Phase 1), Mesothelioma
Phase 1 Dose Escalation and Expansion to Evaluate AROG4-01 in Patients With Advanced Solid Tumors
The goal of this clinical trial is to learn if drug AROG4-01 is safe in patients with solid tumors who have no available treatment alternative. Different doses will be tested in order to identify the most suitable one.
- Conditions
- Solid Tumors (Phase 1), Mesothelioma, Colorectal Carcinoma, Ovarian Cancer
- Trial name
- AROG4-01-01 (NCT06652529)
- Testing
- AROG4-01
- Volunteers
- 35 people
- Sponsor
- Aromics Therapeutics
Colorectal Cancer (Diagnosis), Adenoma
S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas
This study will enroll a total of 18 patients who have undergone curative surgery for stage I or II colorectal cancer and are planned for post-surgical surveillance without any need for chemotherapy at Cedars-Sinai Medical…
- Trial name
- NCT07582003
- Testing
- S-Adenosylmethionine (SAMe)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jun Gong, MD
Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Severe Dysplasia
Piecemeal Versus En Bloc Resection of Large Rectal Adenomas
Currently, colonoscopy is the safest way to detect bowel tumors and polyps, since these can be biopsied and removed in one working process.
- Conditions
- Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Severe Dysplasia, Colorectal Adenomatous Polyp, Colorectal Low Grade Intraepithelial Neoplasia
- Trial name
- PERLA (NCT02238938)
- Testing
- en-bloc resection, piecemeal resection
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 110 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms
Evaluation of Skin Tests in Biotherapy Allergies
Biotherapies are biological (extracted from an organism or living tissue) or biotechnological drugs used in the treatment of multiple conditions, such as autoimmune inflammatory diseases, cancers, and hematologic diseases.
- Conditions
- Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms, Small Cell Bronchial Carcinomas, Bronchial Carcinoma
- Trial name
- ETCABIO (NCT06971848)
- Testing
- Drug skin tests (investigating hypersensitivity to a biotherapy)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
- Trial name
- NCT05544929
- Testing
- KFA115, pembrolizumab
- Where
- 18 sites in United States, Canada and 10 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Colorectal Cancer Prevention, Colorectal Adenoma
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating…
- Trial name
- BILMOD (NCT07162337)
- Testing
- Increased Plant-Based Diet and Decreased Animal-Based Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Mesothelioma, Glioblastoma
Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
- Conditions
- Mesothelioma, Glioblastoma, Renal Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT04913337
- Testing
- NGM707, NGM707 plus pembrolizumab (KEYTRUDA®)
- Where
- 27 sites in United States, South Korea and 1 more
- Volunteers
- 179 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Gut Microbiota, Metachronous Adenoma
Gut Microbiota Prediction of Metachronous Colorectal Neoplasms
Patients with colorectal cancer are known to be at high risk of developing metachronous adenoma, however, participation in colonoscopy are low.
- Trial name
- NCT03383159
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Cancer, Solid Tumor
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
A Phase 1B/2A study will be conducted to establish safety and dose level of AMXT 1501 dicaprate in combination with IV DFMO, in cancer patients.
- Conditions
- Cancer, Solid Tumor, Solid Carcinoma, Advanced Cancer
- Trial name
- NCT05500508
- Testing
- AMXT1501, DFMO
- Where
- 7 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Aminex Therapeutics, Inc.