Clinical trials: Rectal Cancer, Radiotherapy
Rectal Cancer, Locally Advanced
SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer
The goal of this phase 2 study is to learn about the efficacy and safety of short-course radiotherapy (SCRT) sequential Penpulimab in combination with CAPEOX in the neoadjuvant treatment of microsatellite stable (MSS) locally…
- Trial name
- SPARC (NCT05576480)
- Testing
- Short-course radiotherapy, Penpulimab, CAPEOX
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Ruijin Hospital
Locally Advanced Rectal Cancer
Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer
This is a phase II/III, multi-center, open-label, 3-arm, randomized controlled trial assessing the efficacy and safety of neoadjuvant long-course chemoradiation combined with Tislelizumab (PD-1 inhibitor) and subsequent TME…
- Trial name
- NCT05245474
- Testing
- Long-course chemoradiation, with or without Tislelizumab (PD-1 inhibitor)
- Where
- 8 sites in China
- Volunteers
- 186 people
- Sponsor
- Beijing Friendship Hospital
Metastatic Colorectal Carcinoma, Metastatic Lung Non-Small Cell Carcinoma
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer
This randomized phase II trial studies the side effects of durvalumab and tremelimumab and to see how well they work with or without high or low-dose radiation therapy in treating patients with colorectal or non-small cell lung…
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Colorectal Cancer AJCC v7, Stage IV Lung Non-Small Cell Cancer AJCC v7
- Trial name
- NCT02888743
- Testing
- Durvalumab, Radiation Therapy, Tremelimumab
- Where
- 42 sites in United States, Canada
- Volunteers
- 110 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer
Neoadjuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer
RATIONALE: Preoperative 5-Fu based chemoradiation has become standard treatment for stage 2/3 rectal cancer. However whether these patients, especially T3N0-1M0 patients, really need radiation for local control after total…
- Trial name
- FOWARC (NCT01211210)
- Testing
- fluorouracil, fluorouracil, oxaliplatin
- Where
- China
- Volunteers
- 495 people
- Sponsor
- Sun Yat-sen University
Organ Preservation, Rectal Cancer
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
The goal of this prospective phase II feasibility study is to evaluate two additional local treatment options in rectal cancer patients with a good clinical response after neoadjuvant (chemo)radiation: contact x-ray brachytherapy…
- Conditions
- Organ Preservation, Rectal Cancer, Quality of Life, Locally Advanced Rectal Carcinoma
- Trial name
- OPAXX (NCT05772923)
- Testing
- Contact x-ray brachytherapy, Local excision
- Where
- 7 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Rectal Cancer
Total Neoadjuvant Induction and Consolidation CapeOX Plus IMRT With Capecitabine for MRI Defined High-risk Rectal Cancer
This study is designed to test the efficacy and safety of total neoadjuvant induction and consolidation CapeOX plus neoadjuvant intensity modulated radiotherapy with concurrent capecitabine for MRI defined high-risk rectal cancer.
- Trial name
- NCT02864849
- Testing
- Oxaliplatin, Capecitabine, Intensity modulated radiotherapy
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Peking University Cancer Hospital & Institute
Rectal Neoplasms
CORE: Capecitabine, Oxaliplatin, Radiotherapy and Excision
Primary objective: Pathological complete response (ypT0N0) rate Secondary objectives: Histopathological R0 resection rate Pathological downstaging (ypT0-T2N0) rate One month surgical complication rate Predictive value of…
- Trial name
- NCT00174616
- Testing
- Oxaliplatin, capecitabine, radiotherapy
- Where
- 7 sites in Belgium, France and 5 more
- Volunteers
- 87 people
- Sponsor
- Sanofi
Liver Metastases, Colorectal Cancer
Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial Stereotactic Body Radiation Therapy in Patients With Colorectal Cancer
The role of radiotherapy in metastatic cancer has historically been limited to palliation while metastasectomy or radiofrequency has emerged as playing a major role in disease control.
- Trial name
- OLIVER (NCT03532204)
- Testing
- SBRT, Chemotherapy
- Sponsor
- UNICANCER
Anal Cancer
Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy
A commercially available vaginal dilator set will be used as measuring device. The grading of vaginal stenosis will be determined as difference of the diameter of vaginal dilator to the baseline.
- Trial name
- DILANA (NCT04094454)
- Testing
- special tampon with a diameter of 28mm, standard tampon with a diameter of 12-13mm
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Juergen Debus
Rectal Cancer, Radiotherapy
Adaptive Individualized High-Dose Radiotherapy Analysis-REctum-1 (AIDA-RE-1)
Aim of the study is to evaluate achievement of complete pathologic response (pCR) in high-risk rectal cancer treated with neoadjuvant concomitant chemotherapy plus adaptive-intensity modulated imaging-guided radiotherapy
- Conditions
- Rectal Cancer, Radiotherapy, Neoadjuvant Treatment
- Trial name
- NCT03479814
- Testing
- IMRT-SIB plus sequential IG-RT boost
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Locally Advanced Rectal Cancer
Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal Cancer
To explore the complete response (CR) rate of modified short-course radiotherapy plus CAPOX and Tislelizumab versus Long-course Chemoradiotherapy plus Tislelizumab for locally advanced rectal cancer.
- Trial name
- NCT07469306
- Testing
- Modified Short-course radiotherapy, Long-course radiotherapy, Oxaliplatin
- Where
- 3 sites in China
- Volunteers
- 130 people
- Sponsor
- Fujian Cancer Hospital
Rectal Cancer, Radiotherapy
PRediction of Outcomes and PERsonalized Radiotherapy by Biomarkers and Functional Imaging
This is a study focused on analyses of peripheral blood (tissue study). The aim of the trial is to determine whether it is possible to predict early clinical and/or pathological responses after radiotherapy in the setting of…
- Trial name
- NCT06730035
- Testing
- Blood analysis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Locally Advanced Rectal Cancer, Neoadjuvant Therapy
Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC)
SERRAC is a prospective, multicentre, randomized phase II trial. 138 LARC (T3-4/N+M0, distance from anal verge ≤10cm) patients will be treated with neoadjuvant therapy and assigned to Group A and Group B (1:1).
- Trial name
- NCT07150949
- Testing
- Long-course radiotherapy, Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Fudan University
Anal Cancer, Bladder Cancer
Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer
RATIONALE: Fiber may lessen bowel side effects caused by radiation therapy. It is not yet known whether a high-fiber diet is more effective than a low-fiber diet in preventing bowel side effects caused by radiation therapy.
- Conditions
- Anal Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer
- Trial name
- NCT01170299
- Testing
- dietary intervention, laboratory biomarker analysis, gastrointestinal complications management/prevention
- Where
- United Kingdom
- Volunteers
- 177 people
- Sponsor
- Royal Marsden NHS Foundation Trust
CRC (Colorectal Cancer)
Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM
Efficacy and safety of retlirafusp alfa combined with bevacizumab and chemotherapy with or without short-course radiotherapy in conversion therapy for advanced colorectal cancer liver metastases: an exploratory study.
- Trial name
- NCT07728019
- Testing
- SCRT, Retlirafusp alfa Injection, Bevacizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colorectal Cancer
Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer
The purpose of this study is to first determine the maximum tolerated dose of capecitabine given alone or in combination with valproic acid during preoperative short-course radiotherapy (Phase 1).
- Trial name
- V-shoRT-R3 (NCT01898104)
- Testing
- preoperative radiation therapy, Valproic Acid, Capecitabine
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- National Cancer Institute, Naples
Rectal Neoplasms Malignant
CAPOX and Bevacizumab With or Without Primary Tumor Radiotherapy and Iparomlimab and Tuvonralimab as First-line Treatment for RAS-Mutant/MSS Metastatic Rectal Cancer
Research objective: To compare the efficacy and safety of Capox + Bev versus Capox + Bev combined with primary site radiotherapy + (Iparomlimab and Tuvonralimab) as the first-line treatment for RAS Mutation/pMMR metastatic rectal…
- Trial name
- NCT07383285
- Testing
- Iparomlimab and Tuvonralimab, Radiotherapy to the primary site, Capecitabine
- Volunteers
- 106 people
- Sponsor
- Peking University Cancer Hospital & Institute
Adenocarcinoma of Rectum
A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum
This is a multi-centre randomised trial comparing long course (LC) preoperative chemoradiation with short course (SC) preoperative radiotherapy for patients with localised T3 rectal cancer.
- Trial name
- NCT00145769
- Testing
- Short Course Adjuvent Chemotherapy, Long Course Adjuvant Chemotherapy, Short Course Radiotherapy
- Where
- 34 sites in Australia, New Zealand
- Volunteers
- 326 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Rectal Adenocarcinoma
Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
Surgery is the primary treatment for rectal cancer. However, in patients with locally advanced disease, direct surgery often fails to achieve complete tumor resection.
- Trial name
- REFIRT (NCT07161115)
- Testing
- Reduced-field short-course radiotherapy, Immunotherapy combined with chemotherapy, Standard short-course radiotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Longhao Li
Rectal Cancer, Recurrent
Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion
Prospective phase II clinical study aim to explore the clinical outcome of patients with unresectable locally recurrent rectal cancer (LRRC) treated with re-irradiation by carbon ion radiotherapy (CIRT)
- Trial name
- NCT05807984
- Testing
- Carbon ion radiation therapy DT: 74Gy/20 fractions
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Xin Cai