Clinical trials: Rectal Cancer, Radiotherapy
Locally Advanced Rectal Cancer
Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test.
Research project for patients with locally advanced rectal cancer in which biological material and health-related personal data are collected.
- Trial name
- LiBReCa (NCT03699410)
- Testing
- Neoadjuvant radiotherapy, Neoadjuvant chemotherapy, Radical surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Dimitri Christoforidis
Rectal Neoplasms
MRI Simulation-guided Boost in Short-course Preoperative Radiotherapy for Unresectable Rectal Cancer
Improvements in downstaging are required when using preoperative chemoradiation for unresectable rectal cancer. There is therefore a need to explore more effective schedules.
- Trial name
- SUNRISE (NCT03714490)
- Testing
- SCPRT, CRT, CAPOX
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer, Rectal Adenocarcinoma
A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer
PRIME-RT is an open label, multi-centre phase II randomised trial with 1:1 allocation between arm A and arm B. The principal research question is whether the addition of durvalumab to FOLFOX chemotherapy and radiation treatment…
- Conditions
- Rectal Cancer, Rectal Adenocarcinoma, Rectal Neoplasms
- Trial name
- PRIME-RT (NCT04621370)
- Testing
- Durvalumab, FOLFOX, Short Course Radiotherapy (Arm A)
- Volunteers
- 48 people
- Sponsor
- Liz-Anne Lewsley
General Surgery, Radiology
Neoadjuvant Radiotherapy Before Surgery for Rectal Cancer, Surgical and Oncological Outcome Analysis, Retrospective Case Control Study in a Single Institute.
Pre-operative radiotherapy for clinical stage 3 rectal cancer outcome analysis, retrospective case-control study.
- Trial name
- NCT06713824
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Taichung Veterans General Hospital
Rectal Neoplasms
Selinexor Combined With Standard Chemoradiation as Neoadjuvant Treatment in Locally Advanced Rectal Cancer
Locally advanced rectal cancer (T3, T4 or lymph node positive tumors) are conventionally treated with 5FU / capecitabine based chemoradiation prior to surgical resection.
- Trial name
- NCT02137356
- Testing
- standard dose pelvic radiation therapy, standard dose capecitabine, dose-escalated selinexor treatment
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Sheba Medical Center
Rectal Cancer, Radiotherapy
PRediction of Outcomes and PERsonalized Radiotherapy by Biomarkers and Functional Imaging
This is a study focused on analyses of peripheral blood (tissue study). The aim of the trial is to determine whether it is possible to predict early clinical and/or pathological responses after radiotherapy in the setting of…
- Trial name
- NCT06730035
- Testing
- Blood analysis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Colon Polyp, Colorectal Carcinoma
Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer
This clinical trial evaluates the effects of exercise therapy on signs of colorectal cancer in colon tissue and blood in people who completed pelvic radiation therapy for prostate cancer.
- Conditions
- Colon Polyp, Colorectal Carcinoma, Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8
- Trial name
- NCT07790718
- Testing
- Aerobic Exercise, Biopsy Procedure, Biospecimen Collection
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Faecal Incontinence With Faecal Urgency, Rectal Cancer
Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery
This study aims to assess and evaluate the clinical efficacy of an intensified form of Percutaneous tibial nerve stimulation (PTNS) compared to standard conservative treatment for low anterior resection syndrome (LARS).
- Conditions
- Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome (LARS>20)
- Trial name
- HiPLARS (NCT07862673)
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Carcinoma, Hepatocellular, Colorectal Neoplasms
Early Biomarkers of Tumor Response in High Dose Hypofractionated Radiotherapy Word Package 3 : Immune Response
This study will follow-up immune cell populations, secreted factors and released nanovesicles in the blood before, during and after high dose radiation therapy which should give new information of the efficacy of the…
- Conditions
- Carcinoma, Hepatocellular, Colorectal Neoplasms, Melanoma, Kidney Neoplasms
- Trial name
- NCT02439008
- Testing
- Blood samples collection before radiotherapy, Blood samples collection during radiotherapy, Blood samples collection after radiotherapy
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Oscar Lambret
Rectal Adenocarcinoma
A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma
This is a phase I study incorporating bavituximab into the care of patients with rectal adenocarcinoma simultaneously treated with capecitabine and radiation therapy.
- Trial name
- NCT01634685
- Testing
- Radiation, Bavituximab, Capecitabine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center