Clinical trials: Rectal Cancer, completed
Colorectal Cancer
An Observational Study of Adjuvant Treatment With Capecitabine (Xeloda) in Combination With Oxaliplatin in Participants With Stage III Colon Cancer
This observational study evaluates the efficacy and safety of capecitabine in combination with oxaliplatin in the adjuvant setting in participants with Stage III colon cancer.
- Trial name
- NCT01442155
- Testing
- Capecitabine, Oxaliplatin
- Where
- 9 sites in Slovakia
- Volunteers
- 74 people
- Sponsor
- Hoffmann-La Roche
Metastatic Colorectal Cancer (MCRC)
Phase I/II Combination With Irinotecan- Erbitux
Part 1: To define the recommended dose of brivanib that can be safely administered in combination with Erbitux (Cetuximab) and irinotecan to subjects with advanced metastatic colorectal cancer (MCRC) Part 2: To compare median…
- Trial name
- NCT00594984
- Testing
- Cetuximab, Irinotecan, Brivanib
- Where
- 12 sites in United States, Argentina and 5 more
- Volunteers
- 38 people
- Sponsor
- Bristol-Myers Squibb
Colorectal Cancer
Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients
The fluoropyrimidines 5-fluorouracil (5FU) and capecitabine (Cp) are among the most commonly used anticancer drugs. Still, there is much controversy about the correct dosing, and the fact that a minority of patients experience…
- Trial name
- FLOXTOX2 (NCT01641458)
- Testing
- 5FU and capecitabine (Xeloda®) dosing based on DPYD genotype, Therapeutic drug monitoring of 5FU
- Where
- 2 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- Cantonal Hospital of St. Gallen
Colorectal Cancer
Study of Trifluridine/Tipiracil (TAS-102) in Patients With Metastatic Colorectal Cancer in Asia
To compare the effects of TAS-102 with placebo in patients with metastatic colorectal cancer refractory or intolerable to standard chemotherapies.
- Trial name
- TERRA (NCT01955837)
- Testing
- TAS-102
- Where
- 4 sites in China, South Korea and 1 more
- Volunteers
- 406 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Rectal Cancer
Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques
The purpose of the study is to compare self-reported health related quality of life after two different operating techniques for low rectal cancer operated by rectal amputation, using a specific and detailed questionnaire.
- Trial name
- APR (NCT01323166)
- Testing
- Excision of the levator muscle
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer T3-4N0-2M0
Procedure RACHEL in Complex Treatment of Rectal Cancer
AIM OF RESEARCH. The aim of our research is to improve the results of the combined treatment of patients with locally advanced rectal cancer using endovascular methods and reservoir and plastic surgery. TASKS OF RESEARCH. 1.
- Trial name
- RACHEL (NCT02022553)
- Testing
- usual rectal cancer surgery, RACHEL
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Voronezh N.N. Burdenko State Medical Academy
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Colon and Rectal Cancer
Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea
Chemotherapy-induced diarrhea (CID) is common in patients with gastrointestinal cancer. We evaluated whether the concentrated phytodietary compound (hereafter referred to as CPC) as a nutritional adjuvant to routine…
- Trial name
- NCT07460596
- Testing
- Concentrated Phytodietary Compound
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Adenoma Colon, Colorectal Cancer
Retrospective Evaluation of 3 Colonic Adenoma Detection Strategies
Retrospective study, single blind (patient), allowing a posteriori clinical data collection of 90 patients during their passage to the ambulatory endoscopy circuit, to consider 3 groups and thus to deduce a colonic adenoma…
- Conditions
- Adenoma Colon, Colorectal Cancer, Colorectal Polyp, Colonic Adenocarcinoma
- Trial name
- COLODETECT (NCT05080088)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer
Increasing Colorectal Cancer Screening Among Filipino Americans
Develop and evaluate in a randomized trial an educational small group intervention to increase colorectal cancer screening among Filipino Americans.
- Trial name
- NCT00742729
- Testing
- Arm 1, Arm 2, Arm 3
- Where
- United States
- Volunteers
- 906 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Robotic, Laparoscopic
Assessing the Benefits of Robotic and Laparoscopic Surgery for Mid and Low Rectal Cancer in Patients: The Charlson Comorbidity Index (CCI)
This retrospective study collected participants who underwent robotic or laparoscopic anterior resection for rectal cancer at the North People's Hospital in Jiangsu from January 2019 to January 2023.
- Conditions
- Robotic, Laparoscopic, Anterior Resection for Rectal Cancer
- Trial name
- NCT06396845
- Testing
- robotic surgery, laparoscopic surgery
- Where
- China
- Volunteers
- 505 people
- Sponsor
- Daorong Wang
Colorectal Neoplasms
Dendritic Cell Vaccination in Patients With Advanced Colorectal Cancer
Dendritic cells loaded with tumor antigens induce cytotoxic T-cells which have been proved capable of killing both melanoma and breast cancer cells. Melanoma and colorectal cancer cells express some common antigens.
- Trial name
- NCT00311272
- Testing
- MelCancerVac
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Metastatic Colorectal Cancer, Recurrent Colorectal Cancer
Phase I/II Trial of Antagonism of HER in GI Cancer
Recruitment to phase I of the PANTHER trial is complete. Phase II, is to evaluate the best overall response rate for AZD8931 + FOLFIRI treatment.
- Trial name
- PANTHER (NCT01862003)
- Testing
- AZD8931, Irinotecan, Folinic Acid
- Where
- 4 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Metastatic Colorectal Cancer, Chemotherapy Effect
Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
This is a single-arm, open-label, single-center prospective phase II study to evaluate the efficacy and safety of rechallenge chemotherapy in the third or later-line treatment in patients with advanced colorectal cancer.
- Trial name
- NCT03485027
- Testing
- the rechallenge regimen
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fudan University
Colorectal Cancer
A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer
This is an international multi-center, prospective, open-label, randomized, adaptive design phase 3 trial of the cancer stem cell pathway inhibitor napabucasin plus standard bi-weekly FOLFIRI versus standard bi-weekly FOLFIRI in…
- Trial name
- CanStem303C (NCT02753127)
- Testing
- Napabucasin, Fluorouracil, Leucovorin
- Where
- 211 sites in United States, Australia and 14 more
- Volunteers
- 1,253 people
- Sponsor
- Sumitomo Pharma America, Inc.
Healthy Lifestyle, Education
Effects of Education After Colorectal Cancer Screening
The aim of this study is to examine the effect of the education given to individuals undergoing colorectal cancer screening on their attitudes, beliefs and healthy lifestyle behaviors.
- Trial name
- NCT06311565
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Colorectal Adenocarcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma
Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer
This phase II trial studies how well nivolumab and metformin work in treating patients with microsatellite stable (MSS) stage IV colorectal cancer that has not responded to previous treatment.
- Conditions
- Colorectal Adenocarcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma, Refractory Colorectal Carcinoma, Stage IV Colorectal Cancer
- Trial name
- NCT03800602
- Testing
- Metformin, Nivolumab
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Rectum Cancer
A Lymph Node Metastasis Predictor (LN-MASTER) in Rectal Cancer
In this study, we aim to develop and validate an easy-to-use machine learning prediction model to preoperatively identify the lymph node metastasis status for rectal cancer patients by using these clinical data from three…
- Trial name
- NCT05493930
- Testing
- The hospital where the treatment is performed
- Volunteers
- 6,578 people
- Sponsor
- Peking Union Medical College
Colorectal Cancer
Screening and Systematic Follow-up for Cardiopulmonary Comorbidity in Patients Having Surgery for Colorectal Cancer
More than one third of patients with colorectal cancer (CRC) suffer from comorbidity such as heart and lung diseases. This comorbidity markedly impairs survival after surgical treatment owing to increased mortality within the…
- Trial name
- NCT02328365
- Testing
- Structured medical follow-up after operation
- Where
- Denmark
- Volunteers
- 202 people
- Sponsor
- Vejle Hospital
Anal Cancer
Identification of Predictive Factors for Physiological Hypermetabolism of the Anal Canal in 18F-FDG PET / CT
Questionnaire to be completed by patients coming for PET to identify the predictive factors of physiological hypermetabolism of the anal canal
- Trial name
- HYPHYCA (NCT03506529)
- Testing
- questionnary
- Where
- 2 sites in France
- Volunteers
- 644 people
- Sponsor
- Centre Francois Baclesse
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