Clinical trials: Rectal Cancer, completed
Chemotherapeutic Agent Toxicity, Colorectal Cancer
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
RATIONALE: Chemoprotective drugs, such as calcium gluconate and magnesium sulfate, may prevent neurotoxicity caused by oxaliplatin.
- Conditions
- Chemotherapeutic Agent Toxicity, Colorectal Cancer, Neuropathy, Neurotoxicity
- Trial name
- NCT01099449
- Testing
- calcium gluconate, magnesium sulfate, oxaliplatin
- Where
- 405 sites in United States, Puerto Rico
- Volunteers
- 362 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Low Anterior Resection Syndrome
Translation of the International Consensus Definition of LARS Into a Bowl Dysfunction Severity Scoring Tool (New LARS Score)
The purpose of this study is to develop a new severity scoring tool for Low Anterior Resection Syndrome (LARS) drawing on the international consensus criteria for LARS as well as opinions of patients with lived-experience of LARS.
- Trial name
- NCT05605600
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Cardiff and Vale University Health Board
Colorectal Cancer
Phase II Trial Assessing Efficacy and Toxicity of Capecitabine and Oxaliplatin in the Treatment of Colorectal Cancer
To assess the efficacy and safety of the combination of capecitabine and oxaliplatin in the 1st, 2nd or subsequent line treatment of metastatic colorectal cancer, and also in the neo-adjuvant and adjuvant setting of resectable…
- Trial name
- NCT00220116
- Testing
- Capecitabine, Oxaliplatin
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Metastatic Colorectal Cancer (mCRC)
Bioequivalence Study Bevacizumab Biosimilar (BEVZ92) Versus Bevacizumab (AVASTIN®) in First-line Treatment mCRC Patients
This is a multicenter, open label, randomized bioequivalence study of BEVZ92 (bevacizumab biosimilar) and Avastin® with 2 parallel arms to compare the pharmacokinetic (PK) profile of BEVZ92 and Avastin® in combination with FOLFOX…
- Trial name
- NCT02069704
- Testing
- Bevacizumab biosimilar (BEVZ92), Avastin® (bevacizumab, reference product)
- Where
- 18 sites in Argentina, Brazil and 3 more
- Volunteers
- 142 people
- Sponsor
- mAbxience Research S.L.
Advanced Solid Tumors, NSCLC
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have…
- Conditions
- Advanced Solid Tumors, NSCLC, Bladder Cancer, HNSCC
- Trial name
- NCT04157985
- Testing
- Continue PD-1/PD-L1 Inhibitors treatment, Discontinue PD-1/PD-L1-1 inhibitor
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Dan Zandberg
Metastatic Colorectal Cancer
A Study Evaluating the Efficacy and Safety of MEGF0444A Dosed to Progression in Combination With Bevacizumab and mFOLFOX-6 in Participants With Previously Untreated Metastatic Colorectal Cancer
This is a Phase II, multicenter, randomized, double-blind, placebo-controlled trial designed to estimate the efficacy of MEGF0444A treatment to disease progression, combined with oxaliplatin + folinic acid + 5-Fluorouracil…
- Trial name
- NCT01399684
- Testing
- 5-Fluorouracil, Bevacizumab, Folinic acid
- Where
- 40 sites in United States, Australia and 3 more
- Volunteers
- 127 people
- Sponsor
- Genentech, Inc.
Postoperative Ileus, Colorectal Cancer
Role of Tibial Nerve Stimulation for Enhanced Postoperative Recovery After Colorectal Surgery
Aim of the study is to evaluate the role of postoperative tibial nerve stimulation in the enhancement of the recovery of bowel function and in shortening the hospital stay.
- Trial name
- TiRex (NCT02433938)
- Testing
- Tibial nerve stimulation
- Volunteers
- 160 people
- Sponsor
- University of Florence
Surgical Site Infection, Postoperative Complications
Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs
Surgical site infection (SSI) is a major postoperative complication after abdominal surgery especially in colorectal field, which significantly increases length of stay (LOS), readmission incidence and expense.
- Conditions
- Surgical Site Infection, Postoperative Complications, Bowel Preparation, Oral Antibiotics
- Trial name
- NCT03856671
- Testing
- Neomycin,metronidazole
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Laparoscopic Colorectal Surgery
HEAT HumiGard Evaluation Study
During long surgical procedures under general anaesthetic, patients' body temperatures sometimes drop below 36°C. This is classified as hypothermia.
- Trial name
- HEAT (NCT04164706)
- Testing
- HumiGard device
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cardiff and Vale University Health Board
Neoplasm, Colorectal, Neoplasm of Lung
Preventing Viral Pandemic Associated Risk of Cancer Death Using Less Invasive Diagnostic Tests- Liquid Biopsies
The purpose of this study is to investigate the feasibility of using ctDNA to support cancer diagnosis and risk stratification where invasive aerosol generating testing (and/or tissue biopsy) is challenging due to infection risk…
- Conditions
- Neoplasm, Colorectal, Neoplasm of Lung, Neoplasm, Bladder, Neoplasms Pancreatic
- Trial name
- PREVAILctDNA (NCT04566614)
- Testing
- ctDNA blood sampling
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer
Capecitabine and Irinotecan in Treating Patients With Locally Advanced, Recurrent, or Metastatic Colorectal Cancer
PURPOSE: Phase II trial to study the effectiveness of combining capecitabine and irinotecan in treating patients who have locally advanced, recurrent, or metastatic colorectal cancer.
- Trial name
- NCT00022698
- Testing
- Capecitabine, Irinotecan
- Where
- 17 sites in United States
- Volunteers
- 67 people
- Sponsor
- Hoffmann-La Roche
Rectal Cancer
A Questionnaire to Assess the Quality of Life of Rectal Cancer Patients With or Without Stoma
The aim of the present prospective study was to evaluate the prediction accuracy of EORTC QLQ-C30/C38 questionnaire in rectal cancer patient(RC).
- Trial name
- NCT01181557
- Where
- Italy
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Diverting Ileostomy, Rectal Cancer
Purse-String Versus Linear Closure After Ileostomy Reversal
This randomized study compared two wound closure and wound care protocols after reversal of a diverting ileostomy in adults previously treated surgically for rectal cancer.
- Trial name
- NCT07892404
- Testing
- Linear Wound Management Protocol, Purse-String Wound Management Protocol
- Where
- Ukraine
- Volunteers
- 23 people
- Sponsor
- Dnipro Regional Clinical Oncology Dispensary
Pancreatic Cancer, Esophageal Cancer
In Vivo Assessment of Hypoxia in Gastro-intestinal Cancer Using 18F-HX4-PET: an Optimization and Reproducibility Study
Several studies have shown that tumour hypoxia may have a negative impact on the outcome of anticancer treatment. Assessment of tumor hypoxia at baseline or shortly after start of treatment may serve as a predictive marker to…
- Conditions
- Pancreatic Cancer, Esophageal Cancer, Rectal Cancer
- Trial name
- HYPE (NCT01995084)
- Testing
- [F-18]HX4
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Cancer, Colonoscopy Preparation
The Effect of Nurse Process on Bowel Cleansing
Colonoscopy is still the gold standard method for the diagnosis and treatment of colon cancers. Preparation for colonoscopy is a complex processa (eg.
- Conditions
- Colorectal Cancer, Colonoscopy Preparation, Boston Bowel Preparation Scale, Nursing
- Trial name
- NCT06453655
- Testing
- Nursing Process
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Colorectal Cancer
Study to Assess Colonic Microbiota Changes in Response to Energy Drink Consumption
This study will investigate whether short-term daily energy drink consumption results in an increase in hydrogen sulfide-producing bacteria in adults 18-40 years old.
- Trial name
- ROSANNA (NCT06137248)
- Testing
- Energy drink
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Florida
Colorectal Cancer
Comparative Effectiveness of CTC & OC
The goal of this study is to compare the findings of virtual (CT-colonography) with findings of optical colonoscopies to determine if virtual colonoscopy is suitable for colorectal cancer surveillance.
- Trial name
- NCT02143115
- Testing
- Optical colonoscopy, CT-Colonography
- Where
- 5 sites in United States
- Volunteers
- 244 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer
Peptide Vaccine and S-1/CPT-11 Therapy for Patients With Unresectable Advanced Colorectal Cancer
The purpose of this study is to evaluate the safety and immune response of different doses of RNF43-721 emulsified with Montanide ISA 51 in combination with S-1/CPT-11 chemotherapy.
- Trial name
- NCT00641615
- Testing
- RNF43-721
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Kazuhiko Yoshimatsu
Colorectal Cancer
Phase I / II Study of Irinotecan (CPT-11) Combined With l-Leucovorin (l-LV) and 5-FU in Patients With Advanced Colorectal Cancer
We performed a phase I/II study of CPT-11/5FU/l-LV in advanced colorectal cancer, to determine the optimal dose of CPT-11 and to estimate the safety and efficacy of this regimen
- Trial name
- NCT00209625
- Testing
- irinotecan, leucovorin, fluorouracil
- Where
- Japan
- Volunteers
- 23 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Colorectal Cancer
Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00425152
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Volunteers
- 2,151 people
- Sponsor
- NSABP Foundation Inc
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