Clinical trials: Rectal Cancer (Stage III)
Colorectal Cancer
Comparison of Two Types of Surgery in Treating Patients With Rectal Cancer
RATIONALE: Surgery to remove the tumor may be an effective treatment for rectal cancer. It is not yet known whether one type of surgery is more effective than another for rectal cancer.
- Trial name
- NCT00007930
- Testing
- conventional surgery, laparoscopic surgery
- Where
- 3 sites in China, Singapore
- Volunteers
- 800 people
- Sponsor
- National Medical Research Council (NMRC), Singapore
Metastatic Colorectal Cancer
Comparing Efficacy and Safety of Cetuximab (CinnaGen) Versus Erbitux® (Merck) in Metastatic Colorectal Cancer
The study is designed as phase III, randomized, two armed, parallel, double blind (patient and assessor blinded), active controlled, and equivalency clinical trial with primary endpoint of Progression-Free Survival of Cetuximab®…
- Trial name
- NCT03391934
- Testing
- Cetuximab + FOLFIRI
- Where
- Iran
- Volunteers
- 234 people
- Sponsor
- Cinnagen
Colorectal Cancer
Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. SU5416 may stop the growth of tumor cells by stopping blood flow to the tumor.
- Trial name
- NCT00021281
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder
Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies
This study is being done to determine the dose of a chemotherapy drug (irinotecan [irinotecan hydrochloride]) that can be tolerated as part of a combination of drugs.
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder, Adenocarcinoma of Unknown Primary, Adult Primary Cholangiocellular Carcinoma
- Trial name
- NCT01643499
- Testing
- oxaliplatin, irinotecan hydrochloride, leucovorin calcium
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- University of Chicago
Colorectal Cancer
Conventional Surgery Compared With Laparoscopic-Assisted Surgery in Treating Patients With Colorectal Cancer
RATIONALE: Laparoscopic-assisted surgery is a less invasive type of surgery for colorectal cancer and may have fewer side effects and improve recovery.
- Trial name
- NCT00003354
- Testing
- conventional surgery, laparoscopic surgery
- Where
- 13 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Medical Research Council
Colorectal Cancer
Circulating Tumor DNA Methylation Guiding Postoperative Adjuvant Chemotherapy in Stage III Colorectal Cancer
The goal of this randomized controlled trial is to investigate whether ctDNA methylation is a more precise indicator to guide postoperative adjuvant chemotherapy in stage Ill colorectal cancer.
- Trial name
- cmPAT (NCT06167967)
- Testing
- ctDNA methylation, standard treatment
- Where
- China
- Volunteers
- 990 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
Preoperative Hyperfractionated Radiotherapy or Radiochemotherapy in Locally Advanced Rectal Cancer.
Clinical objective of the study is to compare the rates of pathologic response, acute toxicity and sphincter preservation with two schedules of preoperative regiment in patients with locally advanced rectal cancer.
- Trial name
- NCT01814969
- Testing
- Hyperfractionated Radiochemotherapy, Hyperfractionated Radiotherapy
- Where
- Poland
- Volunteers
- 260 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Metastatic Colorectal Cancer
CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer
Drugs used against cancer work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as CMAB009, can block tumor growth in different ways.
- Trial name
- NCT03206151
- Testing
- CMAB009, Irinotecan, Folinic acid
- Where
- 2 sites in China
- Volunteers
- 520 people
- Sponsor
- Taizhou Mabtech Pharmaceutical Co.,Ltd
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer
Randomized phase III trial to compare the effectiveness of fluorouracil given by infusion with that of fluorouracil plus eniluracil given by mouth in treating patients who have metastatic, recurrent, or residual advanced…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00003873
- Testing
- fluorouracil, eniluracil
- Where
- United States
- Volunteers
- 950 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7
Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy
This phase I trial studies the side effects and best dose of ropidoxuridine in treating patients with gastrointestinal cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment…
- Conditions
- Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7, Stage II Pancreatic Cancer AJCC v6 and v7, Stage IIA Esophageal Cancer AJCC v7
- Trial name
- NCT02381561
- Testing
- Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Biological Therapy With Combination Chemotherapy in Patients With Colorectal Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining chemotherapy with biological therapy may kill more tumor cells.
- Trial name
- NCT00003063
- Testing
- recombinant interferon alfa, fluorouracil, leucovorin calcium
- Where
- 85 sites in Greece, Italy and 1 more
- Volunteers
- 1,050 people
- Sponsor
- European Institute of Oncology
Colorectal Cancer
S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving drugs in different ways may kill more cancer cells.
- Trial name
- NCT00002593
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Where
- 60 sites in United States, Canada and 2 more
- Volunteers
- 1,135 people
- Sponsor
- SWOG Cancer Research Network
Rectal Neoplasms Malignant, Rectum Carcinoma
Neoadjuvant Chemotherapy in Patients With Moderate Risk Mid Rectal Cancer
The purpose of this study is to determine whether 3 months of neoadjuvant CapOx is non-inferior to neoadjuvant radiotherapy in patients with moderate risk CRM"-" mid rectal cancer.
- Conditions
- Rectal Neoplasms Malignant, Rectum Carcinoma, Rectal Cancer
- Trial name
- RuCorT-02 (NCT04134897)
- Testing
- Capecitabine, Oxaliplatin, Radiotherapy
- Where
- Russia
- Volunteers
- 316 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
This pilot clinical trial studies how well acceptance and commitment therapy works in improving well-being in patients with stage III-IV cancer and their partners.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer
- Trial name
- NCT03112668
- Testing
- Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Anus Neoplasms, Carcinoma, Squamous Cell
Efficacy Study of Chemoradiotherapy With or Without Paclitaxel in Squamous-cell Anal Carcinoma Patients
The purpose of this study is to determine whether the combination of paclitaxel, capecitabine, mitomycin and intensity-modulated radiotherapy is more effective than the standard combination of capecitabine, mitomycin and…
- Conditions
- Anus Neoplasms, Carcinoma, Squamous Cell, Anus Diseases, Neoplasms
- Trial name
- NCT02526953
- Testing
- Paclitaxel, Capecitabine, Mitomycins
- Volunteers
- 314 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Metastatic Colorectal Cancer
Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
The main purpose of this study is to demonstrate the superiority of S 95005 in combination with bevacizumab over capecitabine in combination with bevacizumab.
- Trial name
- SOLSTICE (NCT03869892)
- Testing
- Trifluridine/tipiracil hydrochloride (S95005), Capecitabine, Bevacizumab experimental
- Where
- 190 sites in Argentina, Australia and 23 more
- Volunteers
- 856 people
- Sponsor
- Institut de Recherches Internationales Servier
Breast Cancer, Colorectal Cancer
Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Vaccines made from a patient's tumor tissue may make the body build an immune response to kill tumor…
- Conditions
- Breast Cancer, Colorectal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00002475
- Testing
- allogeneic tumor cell vaccine, autologous tumor cell vaccine, recombinant interferon alfa
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Vincent Medical Center - Los Angeles
Colorectal Cancer
Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety
The purpose of this study is to investigate efficacy and safety of intra-operative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection.
- Trial name
- IOCCRC (NCT01465451)
- Testing
- curative resection for colorectal cancer, intra-operative 5-FU chemotherapy
- Where
- China
- Volunteers
- 695 people
- Sponsor
- Sun Yat-sen University
Solid Neoplasm, Stage III Pancreatic Cancer
Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors
This phase I trial studies the side effects and best dose of palbociclib with cisplatin or carboplatin in treating patients with solid tumors that have spread to other places and usually cannot be cured or controlled with…
- Conditions
- Solid Neoplasm, Stage III Pancreatic Cancer, Stage IIIA Breast Cancer, Stage IIIA Non-Small Cell Lung Cancer
- Trial name
- NCT02897375
- Testing
- Carboplatin, Cisplatin, Palbociclib
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Emory University
Colon Cancer, Rectal Cancer
Effectiveness of High Dose Vitamin D Supplementation in Stage III Colorectal Cancer
This is a pilot study to test whether there is an association between baseline Vitamin D levels, Vitamin D supplementation and survival in patients with stage III colon and stage II/III rectal cancer receiving chemotherapy.
- Trial name
- NCT02603757
- Testing
- cholecalciferol
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Legacy Health System