Clinical trials: Rectal Hypersensitivity
Stage III Breast Cancer, Stage IV Breast Cancer
Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs
The primary objective of this study, sponsored by Travera in Massachusetts, is to validate whether the mass response biomarker has potential to predict response of patients to specific therapies or therapeutic combinations using…
- Conditions
- Stage III Breast Cancer, Stage IV Breast Cancer, Stage III Lung Cancer, Stage IV Lung Cancer
- Trial name
- NCT04985357
- Sponsor
- Travera Inc
Colorectal Tumor
Comparison of Diagnostic Sensitivity Between ctDNA Methylation and CEA in Colorectal Cancer
This is a prospective diagnostic study. This study is to compare the performance between circulating tumor DNA (ctDNA) methylation and carcinoembryonic antigen (CEA) in detecting colorectal tumor.
- Trial name
- NCT05558436
- Testing
- Genome-wide methylation profiling
- Where
- China
- Volunteers
- 662 people
- Sponsor
- Nanfang Hospital, Southern Medical University
CRC Screening, CRC (Colorectal Cancer)
Improving Rates of Diagnostic Colonoscopy in Native Americans
Colorectal cancer (CRC) is the second-leading cause of cancer death in both men and women in the United States. Compared to national averages, Native Americans (NA) endure a disproportionate burden of CRC incidence and…
- Trial name
- YVONNE-DX (NCT07115875)
- Testing
- Digital Outreach, In Person consultation
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Oklahoma
Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms
Evaluation of Skin Tests in Biotherapy Allergies
Biotherapies are biological (extracted from an organism or living tissue) or biotechnological drugs used in the treatment of multiple conditions, such as autoimmune inflammatory diseases, cancers, and hematologic diseases.
- Conditions
- Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms, Small Cell Bronchial Carcinomas, Bronchial Carcinoma
- Trial name
- ETCABIO (NCT06971848)
- Testing
- Drug skin tests (investigating hypersensitivity to a biotherapy)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Colorectal Cancer
Precision Chemotherapy Based on Organoid Drug Sensitivity for Colorectal Cancer
The purpose of this study is to investigate whether chemotherapy guided by patient-derived tumor organoid drug test can improve the outcomes of stage IV colorectal cancer.
- Trial name
- NCT05832398
- Testing
- FOLFOX , FOLFIRI or FOLFOXIRI regimens, FOLFOX or CapeOX regimens
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Rectal Cancer
Endoscopic Ultrasound Predict the Sensitivity of Stage II / III Rectal Cancer Preoperative Concurrent Chemoradiotherapy
The purpose of this study is to determine the role of endoscopic ultrasound measurement of the primary tumor maximum diameter changes in absolute / relative values in predicting the tumor regression after concurrent…
- Trial name
- NCT01582750
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese Academy of Medical Sciences
Non-celiac Wheat Sensitivity
Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03022994
- Testing
- Duodenum and rectum examination
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Palermo
Colorectal Adenoma, Colorectal Neoplasms
Adenoma Detection Rate in Colonoscopy Performed With EndoRings
The study is designed to examine whether colonoscopy using an EndoRings cap has a higher adenoma detection rate than conventional colonoscopy.
- Trial name
- NCT03219918
- Testing
- EndoRings II Distal Attachment
- Where
- Denmark
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Colorectal Neoplasms
Randomised Controlled Trial of a Literacy Sensitive Decision Aid for Bowel Cancer Screening
The purpose of this study is to evaluate a decision aid (written information booklet designed to facilitate informed decision making) to help people aged 55-64 years, with low levels of education and literacy, make an informed…
- Trial name
- NCT00765869
- Testing
- Bowel cancer screening decision aid, Australian Government Bowel Cancer Screening booklet
- Where
- Australia
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Neoadjuvant Therapy
The Clinical Efficacy of Drug Sensitive Neoadjuvant Chemotherapy Based on Organoid Versus Traditional Neoadjuvant Chemotherapy in Advanced Rectal Cancer
This is a prospective multicenter randomized controlled trial study. According to the enrollment criteria, patients with locally advanced rectal cancer who need neoadjuvant therapy before radical surgery were randomly divided…
- Trial name
- NCT05352165
- Testing
- standard long-term therapy, FOLFOX and standard long-term radiotherapy, FOLFIRI and standard long-term radiotherapy
- Volunteers
- 192 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Colorectal Cancer
Histidine and Immunotherapy Response in Colorectal Cancer
This observational study aims to investigate the role of histidine and its transporter SLC15A3 in modulating the sensitivity of colorectal cancer to immunotherapy.
- Trial name
- NCT07586293
- Testing
- Immunohistochemistry or immunofluorescence, Serum metabolomic analysis or ELISA, Flow cytometry
- Volunteers
- 150 people
- Sponsor
- Jing-yuan Fang, MD, Ph. D
Neuropathy, Painful, Chemotherapy-induced Peripheral Neuropathy
Lidocaine for Oxaliplatin-induced Neuropathy
Oxaliplatin-induced neuropathy is a major dose-limiting side effect in patients with colorectal cancer treated with the FOLFOX chemotherapy regimen.
- Conditions
- Neuropathy, Painful, Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer
- Trial name
- NCT03254394
- Testing
- Lidocaine Hydrochloride, FOLFOX regimen
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Validation of an Alternative Biological Test to Increase the Detection Sensitivity of a Colon Tumour
Screening campaigns for colorectal cancer (CRC) involve two steps: the detection of occult blood in stools using a Hemoccult GAIAC test (FOBT) on three consecutive stool samples, followed by colonoscopy if the result is positive.
- Trial name
- VATNIMAD (NCT01270360)
- Testing
- COLOHYBRITEST OR VALIHYBRITEST
- Where
- France
- Volunteers
- 502 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
An Exploratory Study of Treatment Sensitivity and Prognostic Factors in a Efficacy and Safety Study of mFOLFOX6 + Bevacizumab Versus mFOLFOX6 + Panitumumab Therapy in Patients With Chemotherapy-naïve Unresectable Advanced or Recurrent Colorectal Cancer
The purpose of this study is to investigate biomarkers which may be predictors of efficacy and safety of treatment with mFOLFOX6 + bevacizumab versus mFOLFOX6 + panitumumab therapy in patients with chemotherapy-naïve unresectable…
- Trial name
- NCT02394834
- Testing
- oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, panitumumab, oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, bevacizumab
- Where
- 151 sites in Japan
- Volunteers
- 757 people
- Sponsor
- Takeda