Clinical trials: Rectal Resection
Low Anterior Resection Syndrome
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel…
- Trial name
- NCT03215017
- Testing
- Transanal irrigation, Medication
- Where
- 3 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Mirna Abraham-Nordling
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Colorectal Cancer
Evaluation of Short-term Outcomes of Day Surgery for Patients With CuRC
To evaluate the feasibility and safety of laparoscopic colectomy and anterior resection for patients with colon/upper rectal cancer (CuRC) in day surgery center.
- Trial name
- NCT04646915
- Testing
- Day surgery
- Where
- China
- Volunteers
- 120 people
- Sponsor
- West China Hospital
Colorectal Cancer, Indocyanine Green
Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Radical Resection for Colorectal Cancer
Prospective registry study of endoscopic submucosal injection of indocyanine green before laparoscopic radical resection for colorectal cancer
- Trial name
- NCT04207489
- Testing
- endoscopic submucosal injection of indocyanine green before laparoscopic radical operation of colorectal cancer
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jilin University
Rectal Cancer, Rectal Neoplasms
Transverse Coloplasty vs. Side-to-end Anastomosis Following Low Anterior Resection (LAR): CSAR Trial
CSAR Trial's aim is to determine whether the transverse coloplasty pouch or the side-to-end anastomosis as rectal reservoir reconstruction offers the best functional results.
- Conditions
- Rectal Cancer, Rectal Neoplasms, Rectal Tumors, Fecal Incontinence
- Trial name
- CSAR (NCT03074461)
- Testing
- Side-to-End Anastomosis, Transverse Coloplasty
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Colorectal Cancer
Plasma Biomarkers C-RAC, ICORG 12-27, V1
This is an exploratory, translational, non-interventional and multi-centre clinical study.
- Trial name
- NCT02050737
- Where
- 14 sites in Ireland
- Volunteers
- 109 people
- Sponsor
- Cancer Trials Ireland
Colorectal Cancer
Safety Study of Totally Laparoscopic Resection With Natural Orifice Specimen Extraction (NOSE) for Rectosigmoid Cancer
The purpose of this study is to compare the safety and efficacy of laparoscopic resection with natural orifice specimen extraction versus conventional laparoscopic surgery for sigmoid colon or rectal cancer.
- Trial name
- NCT02635503
- Testing
- transrectal specimen extraction, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer
Acupuncture for Enhanced Recovery After Surgery in Patients Undergoing Laparoscopic Colorectal Cancer Resection
Background: Patients who undergo laparoscopic surgical resection of colorectal cancer may experience various post-operative symptoms (e.g., pain, nausea and vomiting, and anxiety) and limitation of daily activities (e.g., walking…
- Trial name
- NCT02388256
- Testing
- acupuncture, early recovery program after surgery
- Where
- 2 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Korean Medicine Hospital of Pusan National University
Anorectal Fistula
Anal Sphincter Reconstruction After High Recurrent Anorectal Fistula Excision
A retrospective analysis of patients treated for recurrent posterior anorectal fistula, who previously had undergone radical excision of fistula-in-ano, was performed.
- Trial name
- NCT04357210
- Testing
- fistula tract excision and anal sphincter reconstruction
- Volunteers
- 14 people
- Sponsor
- Russian Society of Colorectal Surgeons
Rectal Cancer
Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer.
The purposes of this study are to explore the trajectory of symptom distress and balance ability in patients with rectal cancer.
- Trial name
- NCT06006260
- Where
- Taiwan
- Volunteers
- 107 people
- Sponsor
- Chang Gung Memorial Hospital
Rectal Cancer
Phase II Clinical Trial for the Evaluation of the Efficacy of Transanal TME
The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision.
- Trial name
- NCT02406118
- Testing
- Transanal total mesorectal excision
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- National Cancer Center, Korea
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Colorectal Neoplasms, Diverticulitis
Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery.
- Conditions
- Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection
- Trial name
- NCT03042091
- Testing
- Polyethylene Glycol, Neomycin, Metronidazole Hydrochloride
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Thomas Jefferson University
ColoRectal Cancer, Liver Metastasis Colon Cancer
COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation
The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable colorectal liver metastases (≤3cm) and no extrahepatic disease.
- Conditions
- ColoRectal Cancer, Liver Metastasis Colon Cancer, Liver Metastases, Surgery
- Trial name
- COLLISION (NCT03088150)
- Testing
- Thermal ablation, Surgical resection
- Where
- Netherlands
- Volunteers
- 618 people
- Sponsor
- Amsterdam UMC, location VUmc
Rectal Cancer
Comparison of Sphincter Preservation Surgery and Abdominoperineal Resection (APR): Prospective Clinical Trial
Sphincter preservation surgery in low rectal cancer has been increased due to better understanding of tumor biology and advances in surgical technology.
- Trial name
- ASPIRE (NCT01461525)
- Testing
- Abdominoperineal resection, Sphincter preservation surgery
- Where
- 6 sites in South Korea
- Volunteers
- 342 people
- Sponsor
- Seoul National University Hospital
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Colorectal Neoplasms
Effect of TroVax in Patients Having Colorectal Cancer With Liver Metastases Removed
This study will test the safety and efficacy of TroVax in patients undergoing surgical resection of colorectal cancer with liver metastases.
- Trial name
- NCT00259844
- Testing
- TroVax
- Volunteers
- 20 people
- Sponsor
- Cancer Research UK
Low Anterior Resection Syndrome
Acupuncture in Low Anterior Resection Syndrome Treatment
Acupuncture has it's role in treating patients with fecal incontinence and diarrhea-predominant irritable bowel syndrome. There is no trial or case-report assessing it's role in treatment of Low anterior resection syndrome.
- Trial name
- AcuLARS (NCT03916549)
- Testing
- Acupuncture
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Ileostomy
Early Temporary Stoma Closure After Proctectomy
We conducted a prospective randomized study to evaluate the results of early closure of temporary loop ileostomy at eight days in comparison with late closure at two months, after elective rectal resection with low pelvic…
- Trial name
- NCT00428636
- Testing
- ileostomy
- Where
- 3 sites in France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, leucovorin, and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00091312
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 9 sites in Egypt, France and 4 more
- Volunteers
- 1,976 people
- Sponsor
- Federation Francophone de Cancerologie Digestive