Clinical trials: Rectal Resection
Colorectal Cancer
Impact of Probiotics in Modulation of Intestinal Microbiota
The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR.
- Trial name
- NCT01895530
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Maria Isabel Toulson Davisson Correia
Colorectal Cancer
Combined Resection of Colorectal Metastases
This is a Phase II study of combined surgical resection for patients with both intra- and extra-hepatic metastases from colorectal cancer.
- Trial name
- CRC (NCT00606398)
- Testing
- surgical resection for patients with both intra- and extra-hepatic metastases
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Colorectal Cancer
Oxaliplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients Undergoing Surgery for High-Risk Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXPERT-C (NCT00383695)
- Testing
- cetuximab, capecitabine, oxaliplatin
- Where
- 13 sites in Spain, Sweden and 1 more
- Volunteers
- 164 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen
Advanced Cancers
Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer
The goal of this clinical research study is to learn if Lipitor (atorvastatin) or fish oil supplements can help to control side effects of the heart that are commonly seen after lung surgery (such as irregular heartbeat).
- Trial name
- NCT01259284
- Testing
- Atorvastatin, Fish Oil Supplement
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Ileostomy
Early Temporary Stoma Closure After Proctectomy
We conducted a prospective randomized study to evaluate the results of early closure of temporary loop ileostomy at eight days in comparison with late closure at two months, after elective rectal resection with low pelvic…
- Trial name
- NCT00428636
- Testing
- ileostomy
- Where
- 3 sites in France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prevention, LARS - Low Anterior Resection Syndrome
Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)
The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.
- Conditions
- Prevention, LARS - Low Anterior Resection Syndrome, Pelvic Floor Disorders, Rectal Cancer
- Trial name
- CH1 (NCT06519006)
- Testing
- Pelvic floor exercise
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- F. D. Roosevelt University Hospital
Low Anterior Resection Syndrome, Rectal Cancer
Evaluation of a Decision Aid Tool in Rectal Cancer patiënts
Adapt and evaluate a decision aid for patients with rectal cancer. Phase 1 : decision aid testing (Delphi) multicentric Phase 2: pilot test decision aid
- Trial name
- NCT04938336
- Testing
- Delphi Procedure and interviews
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Colorectal Neoplasms
Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia
The investigators hypothesize that gut microbiome composition and the four bacterial gene markers (M3) show dynamic changes after endoscopic resection of advanced neoplasia, some key bacteria are associated with restoration of…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- M3-CAN (NCT05381792)
- Testing
- Bacterial gene markers test
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
Rectal Reconstruction in Treating Patients Who Are Undergoing Surgery for Rectal Cancer
RATIONALE: Rectal reconstruction after surgery to treat rectal cancer may help patients keep some of their bowel function. It is not yet known which method of rectal reconstruction is most effective after surgery.
- Trial name
- NCT00238381
- Testing
- 5 cm colon-J-pouch, side-to-end anastomosis, straight coloanal anastomosis
- Where
- 18 sites in Germany, Switzerland
- Volunteers
- 336 people
- Sponsor
- Swiss Cancer Institute
Metastatic Colorectal Cancer
An Observational Study of Bevacizumab in Chinese Patients With Metastatic Colorectal Cancer
This observational, multicenter, prospective study will evaluate the use of bevacizumab in real clinical practice in chinese patients with metastatic colorectal cancer.
- Trial name
- NCT01860144
- Testing
- Bevacizumab
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Peking University
Rectal Adenocarcinoma
Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During Chemoradiotherapy of Rectal Adenocarcinomas
The objective of the present project is to validate the feasibility of a multimodal radiological pathway while on chemoradiotherapy, in order to validate potentially predictive factors for chemoradiotherapy sensitivity of rectal…
- Trial name
- NCT01619696
- Testing
- Pelvic MRI and F MISO TEP
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Toulouse
Extended Ileal Resection Under Laparotomy, Total Proctocolectomy Under Laparotomy
Postoperative Analgesia in Abdominal Surgery: a Medico-economic Study
Background : Epidural anaesthesia is associated in abdominal surgery with reduced pain and postoperative respiratory complications together with quicker recovery of bowel function.
- Conditions
- Extended Ileal Resection Under Laparotomy, Total Proctocolectomy Under Laparotomy, Colectomy Left/Right/Total Under Laparotomy, Rectosigmoidal Resection Under Laparotomy
- Trial name
- PERIDIGE (NCT01470846)
- Testing
- epidural analgesia, PCA
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Limoges
Anastomotic Leak
PARLAR-02 Trial：Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage
Surgical resection remains the primary treatment for rectal cancer, but the postoperative incidence of anastomotic leakage (AL) is relatively high.
- Trial name
- NCT07036588
- Testing
- Modified Transanal Drainage Tube
- Where
- China
- Volunteers
- 968 people
- Sponsor
- Third Military Medical University
Colorectal Cancer
Postoperative Hepatic Arterial Chemotherapy in High-risk Patients as Adjuvant Treatment After Resection of Colorectal Liver Metastases
Currently, no adjuvant study with hepatic arterial infusion in the adjuvant setting is opened. Recently, the results of a phase II study (NCT00268463, NSABP-C-09) assessing the potential benefit of systemic oxaliplatin and…
- Trial name
- PACHA-01 (NCT02494973)
- Testing
- Oxaliplatin HAI, Oxaliplatin IV, mFOLFOX6
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Rectal Cancer, Colo-rectal Cancer
A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer
The objectives of this study are to: 1. To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 2.
- Trial name
- NCT00226941
- Testing
- Cetuximab, Oxaliplatin, Capecitabine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- George Albert Fisher
Rectal Cancer, Low Anterior Resection Syndrome
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients.
- Trial name
- TEDRMARS (NCT04023448)
- Testing
- transverse coloplasty pouch
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Rectal Cancer, Quality of Life
The OPERa Study: Evaluating QoL After Rectal Cancer Surgery
Advances in rectal cancer management have significantly reduced morbidity and mortality. The most commonly performed operation for rectal cancer is restorative proctectomy (RP), leaving up to 70% with long-term bowel dysfunction…
- Conditions
- Rectal Cancer, Quality of Life, Bowel Dysfunction, Sexual Dysfunction
- Trial name
- NCT04893876
- Volunteers
- 1,200 people
- Sponsor
- Jewish General Hospital
Rectal Neoplasms Malignant, Rectum Carcinoma
Neoadjuvant Chemotherapy in Patients With Intermediate Risk Upper and Mid Rectal Cancer
The purpose of this study is to determine whether 4 cycles of neoadjuvant CapOx chemotherapy is more effective than the upfront surgery in patients with intermediate risk CRM"-" mid and upper rectal cancer.
- Conditions
- Rectal Neoplasms Malignant, Rectum Carcinoma, Rectal Cancer
- Trial name
- RuCorT-01 (NCT04103697)
- Testing
- Capecitabine, Oxaliplatin, Radiotherapy
- Where
- Russia
- Volunteers
- 560 people
- Sponsor
- Blokhin's Russian Cancer Research Center