Clinical trials: Rectum Carcinoma
Rectal Cancer
Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics.
This is a randomized, controlled, parallel study to determine the efficiency of oral antibiotics in reduction of surgical site infection (SSI) in rectal cancer surgery.
- Trial name
- NCT03436719
- Testing
- Oral antibiotic, Intravenous antibiotic, Mechanical Bowel Preparation
- Where
- Russia
- Volunteers
- 280 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Rectal Cancer
Preoperative Chemoradiation With Capecitabine and Cetuximab
feasibility and tolerance of preoperative therapy with Cetuximab in combination with Capecitabine and radiotherapy for patients with locally advanced operable rectal carcinoma collection of response rate (T-downstaging…
- Trial name
- NCT00297128
- Testing
- Capecitabine, Cetuximab
- Where
- 10 sites in Austria
- Volunteers
- 31 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Anal Cancer, Colorectal Cancer
Quality of Life in Patients Undergoing Radiation Therapy for Primary Lung Cancer, Head and Neck Cancer, or Gastrointestinal Cancer
RATIONALE: Gathering information about patients' quality of life during radiation therapy for cancer may help doctors plan the best treatment.
- Conditions
- Anal Cancer, Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer
- Trial name
- NCT00836992
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Mayo Clinic
Rectal Cancer
"Watch and Wait" After Neo-adjuvant Chemoradiotherapy for Primary Locally Advanced Rectal Cancer.
Among patients treated for locally advanced rectal cancer with neo-adjuvant radio-chemotherapy, about 15% will have complete clinical response in terms of no visible tumor or ulcerations on the site of the primary tumor, or…
- Trial name
- NORWAIT (NCT03402477)
- Where
- 7 sites in Norway
- Volunteers
- 86 people
- Sponsor
- Helse Stavanger HF
Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer
This phase I trial studies the side effects and best dose of ropidoxuridine and how well it works when added to the usual chemotherapy treatment (capecitabine) during radiation therapy for the treatment of patients with stage…
- Conditions
- Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
- Trial name
- NCT04406857
- Testing
- Capecitabine, Radiation Therapy, Ropidoxuridine
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Neoplasms, Neoplastic Cells, Circulating
Change of Circulating Tumor Cells During Laparoscopic or Transanal Endoscopic Surgery for Rectal Cancer.
The primary purpose of this study is to compare the changes of circulating tumor cells (CTCs) at different time points in rectal cancer patients undergoing laparoscopic or transanal endoscopic radical resection.
- Conditions
- Rectal Neoplasms, Neoplastic Cells, Circulating, Laparoscopic Surgery, Transanal Endoscopic Surgery
- Trial name
- NCT05109130
- Testing
- Surgical approach
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer
This trial will enroll patients with locally advanced rectal cancer (resectable and non-resectable).The phase Ib dose escalation portion of trial is designed to determine the maximum tolerated dose (MTD) of CRLX101 when combined…
- Trial name
- NCT02010567
- Testing
- CRLX101, Capecitabine, Radiotherapy
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer of Colon, Cancer of Rectum
Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery
To determine whether exercise and nutrition prehabilitation improves patient outcomes after cancer surgery
- Conditions
- Cancer of Colon, Cancer of Rectum, Liver Metastases
- Trial name
- SPECS (NCT04880772)
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Rectal Cancer, Rectal Cancer Recurrent
A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer
This is a prospective single-center, single-arm, open-label, phase II study evaluating the safety, activity, and efficacy of regorafenib in combination with lorigerlimab for the treatment of patients with regrowing or locally…
- Trial name
- NCT07223567
- Testing
- Regorafenib, Lorigerlimab
- Sponsor
- M.D. Anderson Cancer Center
Rectal Neoplasms
No Stoma VS Ghost Stoma in Patients Undergoing Total Mesorectal Excision for Rectal Cancer
This study aimed at comparing the Comprehensive Complication Index (CCI), readmission rates, postoperative hospitalization days, duration of bearing the stoma (months), hospitalization costs, the number of hospitalizations with…
- Trial name
- NCT06225609
- Testing
- Ghost ileostomy, No ileostomy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- fan li
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Rectum Neoplasm, Rectum Polyp
CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery
Cancer of the lowermost part of the intestine (the rectum) is a common disease and both this disease and its treatment can have major impact on patients.
- Conditions
- Rectum Neoplasm, Rectum Polyp, Rectal Cancer
- Trial name
- NCT05793554
- Where
- Ireland
- Volunteers
- 600 people
- Sponsor
- Mater Misericordiae University Hospital
Rectal Cancer, Radiotherapy
A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by Chemotherapy Plus PD-1 Inhibitor Versus Chemotherapy Alone in Locally Advanced Rectal Cancer
This is a prospective, single-arm, biomarker-stratified, multicenter phase 2 clinical trial. All enrolled patients first receive short-course radiotherapy (SCRT), followed by measurement of serum β-hydroxybutyrate (β-HB) levels…
- Conditions
- Rectal Cancer, Radiotherapy, Immunotherapy, Chemotherapy
- Trial name
- NCT07847229
- Testing
- Short-course radiotherapy, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Tao Zhang
Colorectal Cancer, Metastatic Cancer
Cetuximab, Leucovorin, Oxaliplatin, and Fluorouracil With or Without Bevacizumab in Treating Patients With Resectable Liver Metastases From Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab and bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00438737
- Testing
- bevacizumab, cetuximab, fluorouracil
- Where
- France
- Volunteers
- 100 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Anastomotic Leak, Anti-Inflammatory Agents, Non-Steroidal
Risk of NSAIDs on Anastomotic Leak for Rectal Surgery
Conflicting reports of the association between early postoperative non-steroidal anti-inflammatory drugs (NSAIDs) administration and anastomotic leak (AL) after rectal surgery have continued.
- Trial name
- NCT06155175
- Testing
- NSAIDs
- Where
- China
- Volunteers
- 1,969 people
- Sponsor
- Third Military Medical University
Rectal Cancer, Rectal Cancer Patients
Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial
Neoadjuvant fluoropyrimidine-based chemoradiotherapy followed by total mesorectal excision (TME) is the standard of care for locally advanced rectal cancer (LARC); however, pathologic complete response (pCR) rates are low.
- Trial name
- NCT06850090
- Testing
- TAS-102, Capecitabine
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shandong Cancer Hospital and Institute
Rectal Cancer
Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H)
The goal of this clinical trial is to learn about whether it is safe to omit dissection of the No.253 lymph nodes in mid and low rectal cancer surgery.
- Trial name
- NCT06146946
- Testing
- Dissection of the No.253 lymph node, Omitting the dissection of the No.253 lymph node
- Where
- 8 sites in China
- Volunteers
- 1,384 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Biopsy Proven Non Small Cell Lung Cancer, Head and Neck Cancer
A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy
This pilot study will determine changes over time in tumor volume/motion \& patient anatomy, as well as dose distributions to normal organs.
- Conditions
- Biopsy Proven Non Small Cell Lung Cancer, Head and Neck Cancer, Gastrointestinal Cancer, Colorectal Cancer
- Trial name
- NCT02130427
- Testing
- CT scan
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Preoperative radiotherapy combined with 5-fluorouracil/capecitabine is currently the standard treatment for locally advanced rectal cancer.
- Trial name
- ESTIMATE (NCT06239870)
- Testing
- Envafolimab combined with chemoradiotherapy in the whole course of neoadjuvant therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Yunnan Cancer Hospital
Colorectal Cancer, Rectal Tumors
Reconstruction Techniques and Vascular Approach After Laparoscopic Left Hemicolectomy and Rectum Low Anterior Resection
This is an interventional, controlled and randomized single-center clinical trial with patients diagnosed with colorectal cancer that will undergo laparoscopic left hemicolectomy or laparoscopic low anterior resection for rectal…
- Trial name
- TAHR (NCT02746224)
- Testing
- Initially dissection of inferior mesenteric vein, Initially dissection of inferior mesenteric artery, Latero-terminal colorectal anastomosis
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.