Clinical trials: Rectum Carcinoma
Rectal Neoplasms Malignant, Radiotherapy
Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer
This phase II/III trial studies how well neoadjuvant short-course radiotherapy and chemotherapy with or without PD-1 inhibitors works in treating patients with locally advanced rectal adenocarcinoma.
- Trial name
- NCT05484024
- Testing
- Sintilimab, Short-course radiotherapy, CAPOX/mFOLFOX
- Where
- 2 sites in China
- Volunteers
- 588 people
- Sponsor
- Chinese Academy of Medical Sciences
Rectal Cancer, Colon Cancer
Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer
The purpose of this study is to characterize the safety and tolerability of AMG 706 plus panitumumab when administered with either FOLFIRI or FOLFOX4 chemotherapy regimens. This is a Phase 1b clinical study.
- Trial name
- NCT00101894
- Testing
- FOLFOX-4, AMG 706, Panitumumab (Part 1a only)
- Volunteers
- 119 people
- Sponsor
- Amgen
Rectal Cancer
Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer
This study investigates the efficacy of neoadjuvant radiotherapy combined with QL1706 in MSS-type low-grade rectal cancer. This study is a prospective multicohort study, with cohort 1 intended to include patients with low grade…
- Trial name
- NCT06931873
- Testing
- SCRT+Capoex+QL706, LCRT+Capoex+QL706
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Colo-rectal Cancer, Colorectal Cancer Recurrent
Exosome-based Detection of Molecular Residual Disease in Stage II-III Colorectal Cancer
This study aims to establish an exosome-based liquid biopsy signature to detect molecular residual disease (MRD) in stage II-III colorectal cancer (CRC) patients.
- Trial name
- NCT06654622
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- City of Hope Medical Center
Colorectal Carcinoma
Patients With Rectal Cancer: a "Wait-and-see" Approach
Patients with histologically proven adenocarcinoma of the rectum will receive pelvic radiotherapy to a dose of 45Gy in 25 fractions with a tumor boost to a dose of 9Gy in 5 fractions (thus total of 54Gy/30Fx to the primary…
- Trial name
- NCT03001362
- Testing
- Radical external beam radiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Rectal Cancer
Bevacizumab, Erlotinib, and Capecitabine for Locally Advanced Rectal Cancer
The goal of this clinical research study is to find the highest tolerable dose of bevacizumab (Avastin) and erlotinib hydrochloride (Tarceva) that can be given in combination with standard radiation therapy and capecitabine…
- Trial name
- NCT00543842
- Testing
- Bevacizumab, Capecitabine, Erlotinib
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer, Rectal Cancer
Tas-102 and Radioembolization With 90Y Resin Microspheres for Chemo-refractory Colorectal Liver Metastases
This is a phase I dose escalation study (3+3 design) with a dose expansion arm (12 patients) designed to evaluate safety of the combination of Tas-102 and radioembolization using Yttrium-90 (90Y) resin microspheres for patients…
- Conditions
- Colon Cancer, Rectal Cancer, Liver Metastases
- Trial name
- NCT02602327
- Testing
- Tas-102, SIR-Sphere
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Francisco
Rectal Cancer
Bowel Preparation Before Rectal Cancer Surgery
Traditionally bowel preparation before surgery of rectal cancer could be troublesome for patients especially for patients with kidney and cardio- vascular diseases, where salt and electrolyte balance can be a problem.
- Trial name
- NCT00687570
- Testing
- Fresubin Energy Drink, Laxabon®
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Colo-rectal Cancer
Erector Spinae Plane Block as Analgesia in Patients for Colectomy
Management of postoperative pain relief is largely inadequate. Despite the recent advances in pain management, postoperative pain incidence has not decreased; most patients still experience severe pain after major surgery.
- Trial name
- NCT06957574
- Testing
- Bubpivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first…
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma
- Trial name
- NCT02465060
- Testing
- Adavosertib, Afatinib, Afatinib Dimaleate
- Where
- 1,410 sites in United States, Guam and 1 more
- Volunteers
- 6,452 people
- Sponsor
- National Cancer Institute (NCI)
Total Mesorectal Excision, Rectal Neoplasms
RATME Vs LATME in Middle and Low Rectal Cancer
This is a multicenter, superior, randomized controlled trial designed to compare Robotic-assisted total mesorectal excision (RATME) and laparoscopic-assisted total mesorectal excision (LATME) for middle and low rectal cancer.
- Conditions
- Total Mesorectal Excision, Rectal Neoplasms, Robotic Surgical Procedures, Laparoscopy
- Trial name
- NCT06105203
- Testing
- Robotic-assisted total mesorectal excision, laparoscopic-assisted total mesorectal excision
- Where
- China
- Volunteers
- 1,026 people
- Sponsor
- The First Hospital of Jilin University
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer
Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial…
- Trial name
- NCT05526079
- Testing
- Watchfuf waiting
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Henry Ford Health System
Rectal Neoplasms
A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025)
The purpose of this adaptive trial is to compare the progression-free survival of participants with metastatic rectal carcinoma when treated with intravenous (IV) dalotuzumab (MK-0646) + irinotecan therapy relative to…
- Trial name
- NCT01609231
- Testing
- Dalotuzumab, Irinotecan, Cetuximab
- Volunteers
- 11 people
- Sponsor
- Merck Sharp & Dohme LLC
Rectal Cancer
Trial of Using SIB-IMRT in Preoperative Radiotherapy for Locally Advanced Rectum Cancer
Pathological complete response, (pCR) correlates with a favorable overall prognosis in locally advanced rectal cancer patients underwent preoperative chemoradiation, so obtaining a pCR might be beneficial.
- Trial name
- NCT02195141
- Testing
- conventional fraction, SIB
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Chinese Academy of Medical Sciences
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fluorouracil and leucovorin calcium, work in different ways to stop the growth…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00942266
- Testing
- fluorouracil, leucovorin calcium, vorinostat
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Roswell Park Cancer Institute
Rectal Cancer, Advanced Cancer
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal…
- Trial name
- NORAD01 (NCT03875781)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluorescence, Indocyanine Green
Applications of Fluorescence Imaging Guided Lymph Node Dissection and Fluorescence Angiography of Inferior Mesenteric Artery Assisted Left Colic Artery Preservation
To investigate the accuracy of fluorescence angiography technique IMA classification and the impact of lymph node mapping technique on the dissection of No. 253 lymph nodes.
- Conditions
- Fluorescence, Indocyanine Green, Rectal Cancer Surgery
- Trial name
- NCT06033794
- Testing
- Fluorescence laparoscopic system
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Metastatic Colo-rectal Cancer
FOLFOXIRI Plus Panitumumab In Kras and Braf Wild-Type Metastatic Colorectal Cancer
The GONO-FOLFOXIRI regimen demonstrated higher activity and efficacy compared to FOLFIRI in a phase III trial. Panitumumab with oxaliplatin- or irinotecan-based doublets is feasible and associated with improved activity in KRAS…
- Trial name
- TRIP (NCT01358812)
- Testing
- FOLFOXIRI + Panitumumab
- Where
- 10 sites in Italy
- Volunteers
- 37 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Low Rectal Adenocarcinoma
Study of Two Techniques of Rectal Reservoir in Low Anterior Resection of Rectum
The aim of the study CGD-01/2000 was to investigate wheter a transverse coloplasty pouch is able to improve functional results and quality of life after coloanal anastomosis.
- Trial name
- NCT01396928
- Testing
- Colonic reservoir
- Volunteers
- 106 people
- Sponsor
- Hospital Universitari de Bellvitge
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