Clinical trials: Rectum Carcinoma
Mid-Rectal Cancer, Rectal Cancer Stage II
Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer
This project aims to compare the oncological and functional outcomes of patients with mid-rectal cancer who have a low risk of local recurrence (without MRF involvement) and who either receive or do not receive neoadjuvant…
- Conditions
- Mid-Rectal Cancer, Rectal Cancer Stage II, Rectal Cancer Stage III
- Trial name
- CANO (NCT06823297)
- Testing
- Total mesorectal excision, Neoadjuvant Chemotherapy followed by total mesorectal excision
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 436 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Cancer, Lung Cancer
tislelizUMaB in canceR Patients With molEcuLar residuaL Disease
Numerous studies have shown that even when imaging does not reveal the presence of cancer cells, traces of tumor DNA (i.e. originating from cancer cells) can be detected in the blood of certain patients: this is called molecular…
- Conditions
- Cancer, Lung Cancer, Colo-rectal Cancer, Pancreas Cancer
- Trial name
- UMBRELLA (NCT06332274)
- Testing
- Tislelizumab, Blood sampling
- Where
- France
- Volunteers
- 717 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Colorectal Cancer
Impact of PET Scan on the Curative Strategy of Colo-rectal Cancers : A Randomized Study
The risk of recurrence in stage III and IV of colorectal cancers (CRC) is high during the three years following the tumoral resection with curative aim.
- Trial name
- ITEP (NCT00624260)
- Testing
- semi-annual systematic PET-TDM, PET-TDM for current indication
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Locally Advanced Rectal Cancer
Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer
The main purpose of the study was to define maximum tolerated dose (MTD), recommended Phase II dose (RP2D) safety and tolerability of Peposertib in combination with capecitabine and radiotherapy (RT).
- Trial name
- NCT03770689
- Testing
- Peposertib 50 mg, Peposertib 100 mg, Peposertib 150 mg
- Where
- 14 sites in United States, Spain
- Volunteers
- 19 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Rectal Cancer, Rectal Neoplasm
Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer
This is a phase II, prospective open label multi-center study in which subjects with stage II-III rectal cancer will be accrued in order to determine the pathological complete response rate of neoadjuvant pembrolizumab in…
- Trial name
- NCT02586610
- Testing
- Pembrolizumab, Capecitabine, Radiation Therapy
- Sponsor
- Osama Rahma, MD
Lymph Node Metastasis, Cancer of Rectum and Anus
A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node Metastasis
The goal of this clinical trial is to compare in newly diagnosed patients with resectable rectal cancer with lateral lymph node metastasis.
- Conditions
- Lymph Node Metastasis, Cancer of Rectum and Anus, Oxaliplatin, Intestinal Neoplasms
- Trial name
- NCT06048146
- Testing
- Experimental: FOLFOXIRI and Lateral lymph node dissection, Preoperative long-term concurrent chemoradiotherapy and Lateral lymph node dissection
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer
Treatment of "Low Anterior Resection Syndrome" by Percutaneous Nerve Evaluation and Transanal Irrigation
A randomised trial testing the effect of percutaneous nerve evaluation and transanal irrigation on bowel function in patients after low anterior resection for rectal cancer.
- Trial name
- NCT01313026
- Testing
- Percutaneous nerve evaluation
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Colon Rectal Cancer, Surgical Site Infection
Surveillance and Implementation of a Bundle of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat)
The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors surgical site infection (SSI) in elective colorectal surgery since 2007 in 55 public and private acute care hospitals.
- Trial name
- CCR-VINCat (NCT04496635)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 60,000 people
- Sponsor
- Hospital de Granollers
Rectal Cancer, Cancer of Rectum
Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
Neoadjuvant therapy has been widely applied to locally advanced rectal cancer. However, about 50% of patients receiving this therapy do not respond well as evidenced by the fact that their T or N stages are not effectively…
- Conditions
- Rectal Cancer, Cancer of Rectum, Cancer of the Rectum, Neoplasms, Rectal
- Trial name
- NCT03573791
- Where
- 2 sites in China
- Volunteers
- 152 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Rectal Cancer, Moderately Hypofractionated Radiotherapy
Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial
This study aims to observe and evaluate the efficacy and safety of moderately hypofractionated radiotherapy combined with chemotherapy and immunotherapy, compared with conventional neoadjuvant chemoradiotherapy, in patients with…
- Conditions
- Rectal Cancer, Moderately Hypofractionated Radiotherapy, Serplulimab, pMMR/MSS
- Trial name
- NCT07527520
- Testing
- Moderately Hypofractionated Radiotherapy, Serplulimab, CapOx+Long-course radiotherapy
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Fudan University
Breast Cancer, Colo-rectal Cancer
Cancer Mortality Affected by the Choice of Anesthetic Drugs?
Knowledge gap: Does the choice of anaesthetic affect outcome for cancer surgery? Aim: To retrospectively examine possible associations (Cox Multiple Regression) between survival from breast-, colorectal-, or skin cancer and the…
- Conditions
- Breast Cancer, Colo-rectal Cancer, Skin Cancer
- Trial name
- NCT01418326
- Where
- Sweden
- Volunteers
- 3,284 people
- Sponsor
- Enlund
Rectal Cancer
BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University Oncology Research Group Study
The primary goal of this Brown University Oncology Research Group is to determine that a safe dose of BYL719 can be administered with capecitabine and radiation in patients with rectal cancer.
- Trial name
- NCT02550743
- Testing
- BYL719, Capecitabine, Radiation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- howard safran
Neo-adjuvant Short Course Chemo-radiotherapy in Locally Advanced Cancer Rectum
Neo-adjuvant Short Course Chemo-radiation Therapy in Locally Advanced Rectal Cancer Patients
The primary objective of this trial is to assess the safety and feasibility of 5-FU when given concurrently with5 Gy x 5 fractions IMRT.
- Trial name
- NCT04370418
- Testing
- short course chemo-radiation with 5-fluorouracil
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Assiut University
Colorectal Cancer
Assessment of Clinically Related Outcomes and Biomarker Analysis for Translational Integration in Colorectal Cancer
A prospective, observational study on clinical outcomes of surgical management of primary and metastatic colorectal cancer Prospective collection of tissues to explore potential biomarkers in blood and/or primary or secondary…
- Trial name
- ACROBATICC (NCT01762813)
- Testing
- open and laparoscopic surgery
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Helse Stavanger HF
Colorectal Cancer
Oxaliplatin in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Clinical trial to study the effectiveness of oxaliplatin in treating patients who have locally…
- Trial name
- NCT00040820
- Testing
- oxaliplatin
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Transanal Endoscopic Microsurgery (TEM)
Quality of Life After Transanal Endoscopic Microsurgery (TEM)
This is a observational cohort study to determine the influence of Transanal endoscopic microsurgery (TEM) on patients Quality of Life
- Trial name
- QoLTEM (NCT03675243)
- Testing
- sphincterometry
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Rectum Cancer, Rectal Cancer
Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer
This project investigates the clinical and biological impact of combining immunotherapy (pembrolizumab) with short course radiotherapy (5Gy, five times) in the neo-adjuvant treatment of localised microsatellite stable (MSS)…
- Trial name
- PEMREC (NCT04109755)
- Testing
- Pembrolizumab
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Geneva
Rectal Cancer
RECTAL BOOST Study
Randomized controlled trial in which the effect is investigated of a radiation boost in addition to standard chemoradiation in patients with locally advanced rectal cancer on complete response rate defined as pathological…
- Trial name
- RECTAL BOOST (NCT01951521)
- Testing
- Boost
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- UMC Utrecht
Esophageal Cancer, Gastric Cancer
Prospective Analysis of Robot-Assisted Surgery
The robot-assisted surgery allows three-dimensional view, detailed access of small structures, depth perception and articulated movements with wide latitude.
- Conditions
- Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer
- Trial name
- NCT02292914
- Testing
- Robot-assisted surgery, Conventional Surgery
- Where
- Brazil
- Volunteers
- 1,120 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
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