Clinical trials: Rectum Carcinoma
Colon Cancer, Rectal Cancer
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the…
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- TAP (NCT02591407)
- Testing
- TAP Block, Continuous Epidural Analgesia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Trinity Health Michigan
Liver Metastases, Colorectal Cancer Metastatic
Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation
The COLT trial is an investigator-driven, multicenter, non-randomized, open-label, controlled, prospective, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in…
- Conditions
- Liver Metastases, Colorectal Cancer Metastatic, Liver Neoplasm, Neoplasms
- Trial name
- COLT (NCT03803436)
- Testing
- Liver transplant, Chemotherapy
- Where
- 12 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Rectal Cancer
Open or Laparoscopic Mesolectal Excision in Low Rectum Cancer
To compare the open approach and the laparoscopic-assisted approach of dissection of lateral lymph nodes in low advanced rectal cancer patients with clinically suspected nodal metastases in terms of safety, technical feasibility…
- Trial name
- NCT04561830
- Testing
- laparoscopic-assited excision of mesorectum with pelvic lymph nodes excision
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Rectal Adenocarcinoma
Prestoma-Trial for Parastomal Hernia Prevention
Prestoma Trial is designed to compare the safety and efficiency of three different meshes and techniques to prevent parastomal hernia after laparoscopic or robotic-assisted abdominoperineal resection for rectal adenocarcinoma.
- Trial name
- NCT03527784
- Testing
- Parietene Macro, Parietex Parastomal, Dynamesh IPST
- Where
- 6 sites in Finland
- Volunteers
- 14 people
- Sponsor
- University of Oulu
Metastatic Colorectal Cancer
ImmunoTEP With 68-Ga in Metastatic Colo Rectal Cancer
Evaluation of the sensitivity of the immuno-PET PET / CT pretargeted with the bispecific anti-CEA x anti-HSG TF2 antibody and IMP-288 peptide labeled with Gallium-68 for imaging potential candidate patients for surgery of local…
- Trial name
- iTEP Colon (NCT02587247)
- Testing
- TF2 antibody/68Ga-IMP-288
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
Colorectal Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and combining radiation therapy with chemotherapy may kill more tumor cells.
- Trial name
- NCT00002801
- Testing
- leucovorin calcium, tegafur-uracil, radiation therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Urethra Injury, Rectal Cancer
Validation of ICG to Identify the Urethra During Rectal Surgery
This is an open-label feasibility study utilising direct instillation of ICG into the urethra during surgery for low rectal cancers. The trial involves a single intervention taking place during the patient's operation.
- Conditions
- Urethra Injury, Rectal Cancer, Surgery
- Trial name
- NCT03204201
- Testing
- Indocyanine Green Solution
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Rectal Neoplasms
Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer
Rectal cancer is one of the common malignant tumors of the digestive tract. Some patients with rectal cancer are already advanced tumors when they are first diagnosed.
- Trial name
- NECI (NCT05420584)
- Testing
- Arterial chemoembolization, Tislelizumab Injection, XELOX
- Where
- China
- Volunteers
- 83 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Anal Carcinoma, Cervical Carcinoma
Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer
This phase II trial tests the feasibility and side effects of vaginal DHEA to improve vaginal health after radiation for women with gynecologic, anal or rectal cancer.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Rectal Carcinoma
- Trial name
- NCT07407647
- Testing
- Biospecimen Collection, Prasterone, Survey Administration
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Cancer
DJ-927 as Second-Line Therapy in Treating Patients With Progressive Locally Advanced or Metastatic Colorectal Adenocarcinoma
RATIONALE: Drugs used in chemotherapy, such as DJ-927, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00080834
- Testing
- DJ-927
- Where
- 2 sites in United States
- Sponsor
- Daiichi Sankyo
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00039611
- Testing
- FOLFOX regimen, fluorouracil, leucovorin calcium
- Where
- 19 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Colon Carcinoma, Dysplasia in Crohn Disease
Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia
This pilot, randomized phase I/II trial studies how well inositol works in preventing colorectal cancer in patients with abnormal cells (dysplasia) associated with inflammation of the colon (colitis).
- Conditions
- Colon Carcinoma, Dysplasia in Crohn Disease, Low Grade Dysplasia in Ulcerative Colitis, Rectal Carcinoma
- Trial name
- NCT01111292
- Testing
- Inositol
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer
Early-onset Rectal Cancer
The present study aimed to review the characteristics and outcome of early-onset rectal cancer in a subset of Egyptian patients aged 40 years or less.
- Trial name
- NCT04496765
- Testing
- Total mesorectal excision
- Where
- Egypt
- Volunteers
- 244 people
- Sponsor
- Mansoura University
Colorectal Cancer
Celecoxib in Treating Patients With Early-Stage Rectal Cancer
RATIONALE: Studying samples of tissue, blood, and urine from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00608595
- Testing
- celecoxib, gene expression analysis, protein expression analysis
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Rectal Adenocarcinoma
GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis
A prospective, open, multicenter, randomized III trial with two arms: Arm A: Primary tumor resection , followed by chemotherapy Arm B: Chemotherapy alone.
- Trial name
- GRECCAR8 (NCT02314182)
- Testing
- Primary tumor resection + chemotherapy, Oxaliplatin/irinotecan + capecitabine, 5-FUI ± bevacizumab
- Where
- 3 sites in France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Colo-rectal Cancer
Serum Talin-1 and Cripto-1 in Colorectal Cancer
The goals of this study are To evaluate the clinical utility of Talin-1 and Cripto-1 measurement in colorectal cancer patients in comparison with healthy controls.
- Trial name
- Talin-1/CR-1 (NCT07414082)
- Testing
- Serum level of Human Talin-1, Serum level of Human Cripto-1
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Quality of Life, Sexual Function
Effects of Structured Rehabilitation Program on Quality of Life in Rectal Cancer Patients- a Randomized Controlled Trial
Quality of life after rectal surgery is reported to be impaired. Side effects of surgery and/or neoadjuvant treatment as functional disturbances like sexual dysfunction, urinary incontinence, anal incontinence or stoma problems…
- Conditions
- Quality of Life, Sexual Function, Urinary Incontinence, Anal Incontinence
- Trial name
- NCT00895388
- Testing
- Structured Rehabilitation program
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Cancer Patients
Impact Of Metformin In Rectal Cancer Patients
Design: Prospective, randomized controlled clinical trial Setting: at Minia University Hospital and Minia Oncology Institute. Condition: Colorectal cancer.
- Trial name
- NCT06728982
- Testing
- Metformin
- Where
- 2 sites in Egypt
- Volunteers
- 85 people
- Sponsor
- Minia University
Rectal Cancer
MMP-7 Modulation by Short and Long Term Radiotherapy in Rectal Cancer Patients
To analyse the effects of radiation therapy on inflammation and matrilysin levels in rectal cancer patients.
- Trial name
- MMP-7 (NCT03151759)
- Testing
- Neoadjuvant radiotherapy
- Volunteers
- 77 people
- Sponsor
- Region Skane
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