Clinical trials: Rectum Carcinoma
Locally Advanced Malignant Neoplasm
Phase II Study of Preoperative IMRT Combined With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer
Pathological complete response, (pCR) correlates with a favourable overall prognosis in locally advanced rectal cancer patients underwent preoperative chemoradiation, so obtaining a pCR might be beneficial.
- Trial name
- NCT01871363
- Testing
- chemoradiation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Chinese Academy of Medical Sciences
Toripalimab, Radiation
A Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status
pMMR/MSS and 32 dMMR/MSI-H patientspatients were planned to be enrolled. Patients with dMMR/MSI-H will be randomly assigned to the immunotherapy arm or short-course radiotherapy sequential immunotherapy arm; pMMR/MSS patients…
- Trial name
- NCT05669092
- Testing
- Toripalimab, CRT, SCRT
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Zhejiang Cancer Hospital
Colorectal Cancer
Panitumumab and Irinotecan as Third-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- PIMABI (NCT00655499)
- Testing
- Panitumumab, Irinotecan hydrochloride, Chromogenic in situ hybridization
- Where
- 9 sites in France
- Volunteers
- 65 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Cancer Survivor, Colorectal Cancer
Internet-Based Weight-Loss Program for Colorectal Cancer Survivors
RATIONALE: A personalized Internet-based weight-loss program may help improve the quality of life for colorectal cancer survivors.
- Conditions
- Cancer Survivor, Colorectal Cancer, Weight Changes
- Trial name
- NCT01032590
- Testing
- Internet weight loss intervention
- Where
- 2 sites in United States
- Sponsor
- Rutgers, The State University of New Jersey
Rectal Cancer
Intraoperative Angiography Using ICG in Rectal Cancer Patients to Prevent Anastamotic Leak After Laparoscopic Anterior Resection of the Rectum
The study enrols patients with operative rectal cancer qualified for laparoscopic anterior resection. Patients are given first dose of indocyanine green iv intraoperatively (ICG) before choosing the appropriate site of the…
- Trial name
- NCT05263336
- Testing
- Verdye Green
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Jagiellonian University
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs at the time of day that allows for the best drug response may allow the doctor to give higher…
- Trial name
- NCT00039208
- Testing
- fluorouracil, irinotecan hydrochloride, leucovorin calcium
- Where
- 20 sites in Belgium, France and 2 more
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
CRC
Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer
All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds.
- Trial name
- ITB (NCT03336658)
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Locally Advanced Rectal Cancer
Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer
This is a small Phase II study testing whether targeted internal radiation treatment (HDREBT) followed by two doses of the immunotherapy drug Nivolumab is safe, practical, and potentially effective before patients undergo surgery…
- Trial name
- IMPERIA (NCT07645118)
- Testing
- Nivolumab, HDRBET, Total Mesorectal Excision (TME)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Dr. Te Vuong
Rectal Adenocarcinoma
Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal Cancer
The PRELUDE Study: A Prospective Cohort Study Comparing Neoadjuvant Radiotherapy Followed by Total Mesorectal Excision Versus Upfront Surgery in Patients with Locally Advanced Proximal Rectal Cancer The PRELUDE Study is a…
- Trial name
- PRELUDE (NCT07802197)
- Testing
- radiotherapy, surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Rectal Cancer
DETECT: Target Volume for Rectal Endoluminal Radiation Boosting
The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for…
- Trial name
- DETECT (NCT04927897)
- Testing
- Ultrasound, Rectoscopy, Scan, e.g. CT (resection specimen)
- Where
- 3 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht Radiation Oncology
Tumors
One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy
This study will include a one time intravenous (IV) infusion of Clostridium novyi-NT (C. novyi-NT) spores to treat solid tumors which have not responded to standard therapy.
- Trial name
- NCT00358397
- Testing
- Clostridium novyi-NT spores
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Rectal Cancer
Total Neoadjuvant Therapy Versus Standard Therapy of Locally Advanced Rectal Cancer With High Risk Factors for Failure
In a retrospective study, the investigators will compare patients with locally advanced rectal cancer with high risk factors for failure who were treated with standard therapy or with total neoadjuvant therapy.
- Trial name
- NCT04679597
- Testing
- Capecitabine
- Volunteers
- 161 people
- Sponsor
- Institute of Oncology Ljubljana
Rectal Neoplasms
Transanal Total Mesorectal Excision Versus Laparoscopic TME for Rectal Cancer
To investigates the feasibility, practicability, safety and subjective as well as functional outcome of transanal minimal invasive surgery toal mesentery excision for rectal cancer.
- Trial name
- NCT02252250
- Testing
- conventional laparoscopic total mesentery excision, transanal hybrid-laparoscopic total mesentery excision
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Third Military Medical University
Colorectal Cancer, Rectal Cancer
SafeHeal Colovac Colorectal Anastomosis Protection Device Evaluation (SAFE-2) Pivotal Study
A randomized trial to assess the safety and effectiveness of the Colovac in providing temporary protection of the anastomosis in subjects undergoing lower anterior resection for colorectal cancer.
- Conditions
- Colorectal Cancer, Rectal Cancer, Rectal Tumor, Rectal/Anal
- Trial name
- SAFE-2 (NCT05010850)
- Testing
- Colovac, Stoma Creation
- Where
- 16 sites in United States, Belgium and 1 more
- Volunteers
- 18 people
- Sponsor
- SafeHeal Inc
Rectal Cancer, Adenocarcinoma, Neoadjuvant Chemoradiation
Investigation of the Value of ctDNA in Diagnosis, Treatment, and Surveillance of Surgically Resectable Colorectal Cancer
In this study, we aim to investigate the value of circulating tumor DNA (ctDNA) analysis in the diagnosis, treatment, and surveillance of patients with surgically resectable colorectal cancer, by performing serial analysis of…
- Trial name
- NCT03038217
- Testing
- Capecitabine +/- Oxaliplatin, local resection, radical resection
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Rectal Cancer
Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
Low Anterior Resection (LAR) surgery can be done using various techniques. The traditional technique for performing the surgery is through one or multiple incision(s) in the muscular wall of the abdomen.
- Trial name
- NCT03283540
- Testing
- TaTME, TME
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Cancer, Locally Advanced
Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer
A Single-arm phase II trial evaluating induction chemotherapy with FOLFIRINOXm followed by short course radiotherapy (RT) in locally advanced rectal carcinoma
- Trial name
- NCT05868317
- Testing
- Chemotherapy With FOLFIRINOX ( 5 Fluorouracil, Oxaliplatine and Irinotecan), Radiotherapy
- Where
- Tunisia
- Volunteers
- 70 people
- Sponsor
- Salah Azaïz Cancer Institute
Rectal Cancer, Surgery
Assessment of Functional Digestive and Genitourinary Outcomes in Patients With Rectal Cancer.
Total mesorectal excision and neoadjuvant radio-chemotherapy have revolutionized the management of rectal cancer allowing an increase in survival (between 55 and 68% at 5 years) and allowing a decrease of local recurrence (under…
- Trial name
- Rectqol (NCT03459235)
- Testing
- quality of life
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Caen
Rectal Cancer
Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer
To analyze the occurrence of defecation complications, rectal function, and quality of life indicators after sphincter-preserving surgery for middle and low rectal cancer, the stoma exudate was collected before the stoma was…
- Trial name
- NCT05461248
- Testing
- stoma drainage reinfusion, Standard of Care - No Return of Stoma Drain
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Hospital of Jilin University
Rectal Cancer
Comprehensive Management of Rectal Cancer
study on the strategy we have adopted for rectal cancer treated with chemoradiotherapy in the case of a complete reponse ( surveillance vs. surgery) Particular Case of Patients with Complete Response After CRT.
- Trial name
- CMRC (NCT06839508)
- Testing
- Radio chemotherapy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier de Saint-Denis
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