Clinical trials: Rectum Neoplasm
Rectal Cancer
The Development of a Patient Reported Outcomes Measure Committed to the Watch-and-wait Program for Rectal Cancer
The purpose of this study to develop an international tool that can be used to assess burden of disease in patients enrolled in the W\&W program for rectal cancer
- Trial name
- NCT05040646
- Testing
- Delphi exercise
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Rectal Cancer, Low Anterior Resection
Feasibility Bowel Dysfunction Program After Low Anterior Resection
This study will facilitate a better understanding of the overall experience of our rectal cancer survivors after Low Anterior Resection for rectal cancer.
- Trial name
- NCT04733794
- Testing
- Stoma reversal
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer
Biomarkers in Predicting Response to Cetuximab in Patients With Advanced Colorectal Cancer
RATIONALE: Studying samples of tissue in the laboratory from patients who received cetuximab may help doctors understand and predict how well patients will respond to treatment.
- Trial name
- NCT01243372
- Testing
- mutation analysis, laboratory biomarker analysis
- Volunteers
- 1,142 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Neoplasms
Endoscopic Posterior Mesorectal Resection in T1 Rectal Cancer
Any efforts to spare patients with T1 carcinomas of the rectum from low anterior resection or even abdominoperineal resection are linked to the risk of locoregional recurrence of about 10% (range, 0-24).
- Trial name
- NCT00531297
- Testing
- endoscopic posterior mesorectal resection
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Cantonal Hospital of St. Gallen
Rectal Cancer Stage II, Rectal Cancer Stage III
Neoadjuvant Regorafenib in Combination With Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer
This is a multicenter, single-arm, phase II study of nivolumab in combination with regorafenib in subjects with locally-advanced rectal cancer who are eligible for a curative treatment including pre-operative SCRT and TME(or…
- Trial name
- REGINA (NCT04503694)
- Testing
- Nivolumab 10 MG/ML Intravenous Solution, Regorafenib 30 MG Oral Tablet, Radiotherapy
- Where
- 9 sites in Belgium
- Volunteers
- 72 people
- Sponsor
- Jules Bordet Institute
Colon Cancer, Rectal Cancer
Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer
This study is a pilot interventional study evaluating an individualized, comprehensive rehabilitation approach for patients with colorectal cancer in Slovenia.
- Trial name
- NCT07428239
- Testing
- Individualized Comprehensive Rehabilitation
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- Institute of Oncology Ljubljana
Rectal Cancer
Assessment of Symptoms and Consequences of Coloanal Continuity Reconstruction
This study is a prospective, monocentric study whose aim is to assess the quality of life for patients who underwent a coloanal continuity reconstruction and to understand the functional issues they encounter.
- Trial name
- QUALIPRO (NCT03292289)
- Testing
- Pre- and post-operative consultation, Stomatherapy consultation, Questionnaires
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Oscar Lambret
Rectal Neoplasms
Rectrospect - a Retrospective Study of Treatment Response
Biopisies from patients diagnosed with rectal cancer between 2007-2019 will be cut into 4-6 micrometer thin sections for morphology and immunostaining.
- Trial name
- Rectrospect (NCT04787523)
- Testing
- Radiotherapy
- Where
- Sweden
- Volunteers
- 170 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer
Chemotherapy Combined With High-dose Radiotherapy for Low Rectal Cancer Using MR Guided Linear Accelerator
The incidence rate of colorectal cancer is third in male tumors and second in female tumors. The newly diagnosed incidence of colorectal cancer is no less than 100 thousand in China, which poses a great threat to people's health…
- Trial name
- NCT05338866
- Testing
- Magnetic resonance guided radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer
The National Comprehensive Cancer Network (NCCN) guidelines recommend trimodality treatment for patients with middle and low LARC with neoadjuvant chemoradiotherapy (NA-CRT), surgical resection with TME, plus additional…
- Trial name
- NCT05274945
- Testing
- Radiotherapy, consolidation chemotherapy, TME or APR
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Alexandria University
Rectal Cancer, Quality of Life
Quality of Life After Rectal Cancer Surgery
Following colorectal surgery, many patients face a combination of physical and emotional problems for a long period of time. Symptoms such as pain, fatigue, and disturbed bowel and sexual function, as well as problems in social…
- Trial name
- NCT04455945
- Testing
- Open Rectal cancer surgery, Laparoscopic Rectal cancer surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Rectal Neoplasms
Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer
This study aims to evaluate the efficacy and safety of tislelizumab combined with simultaneous integrated boost intensity-modulated radiotherapy in treating locally advanced rectal cancer.
- Trial name
- NCT06017583
- Testing
- Tislelizumab, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Yong Zhang,MD
Colorectal Cancer, Metastatic Cancer
Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating Unresectable Liver Metastases in Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways.
- Trial name
- NCT00043004
- Testing
- bevacizumab, FOLFOX regimen, fluorouracil
- Where
- 43 sites in Austria, Belgium and 8 more
- Volunteers
- 119 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia
RATIONALE: Studying samples of blood and tissue from patients at risk of cancer in the laboratory may help doctors learn more about the effect of folate on DNA and identify biomarkers related to cancer.
- Trial name
- NCT00611000
- Testing
- folic acid, DNA methylation analysis, gene expression analysis
- Volunteers
- 20 people
- Sponsor
- Rockefeller University
Anus Neoplasms, Rectal Neoplasms
Alkagin Paste in the Prevention of Radiation Dermatitis
The purpose of this study is to determine whether Alkagin paste is effective at preventing radiodermatitis in patients receiving external beam radiation therapy to the perineal area.
- Conditions
- Anus Neoplasms, Rectal Neoplasms, Urogenital Neoplasms
- Trial name
- NCT01408407
- Testing
- Aveeno cream, Alkagin paste
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Rectal Neoplasm
Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study
The introduction of neoadjuvant chemoradiation therapy (CRT) and the use of advanced surgical techniques have led to a reduction in mortality and recurrence rates for rectal cancer, the rate of which currently stands at 4-8%.
- Trial name
- RETRY (NCT05984576)
- Testing
- Reirradiation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer
Gefitinib in Treating Patients With Recurrent Metastatic Colorectal Cancer
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of the tumor cells and slow the growth of recurrent metastatic colorectal cancer.
- Trial name
- NCT00025350
- Testing
- gefitinib
- Where
- 16 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Rectal Cancer Stage, Oesophageal Cancer
PD-L1 PET Imaging During Neoadjuvant (Chemo)Radiotherapy in Esophageal and Rectal Cancer
The overall aim of this pilot study is to prospectively monitor programmed death-ligand 1 (PD-L1) expression dynamics in vivo, during neoadjuvant chemoradiotherapy (CRT) or short-course preoperative radiotherapy (SCPRT) in rectal…
- Trial name
- PETNEC (NCT04564482)
- Testing
- CRT, SCPRT, CROSS Protocol
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Johannes Laengle, MD, PhD
Rectal Cancer, Defect of Floor of Lesser Pelvis
Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer
The trial compares two different techniques for reconstruction of the lesser pelvic floor after an extended abdominoperineal excision for locally advanced rectal cancer.
- Trial name
- NEAPE (NCT01347697)
- Testing
- Reconstruction with an acellular porcine dermal collagen implant (biological mesh), Reconstruction with a gluteus maximus myocutaneous flap
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Rectal Cancer
Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT)
To investigate a potential toxicity benefit of preoperative radiation therapy with protons compared to conventional photon beam radiation therapy in patients with locally advanced rectal cancer.
- Trial name
- PRORECT (NCT04525989)
- Testing
- Radiation therapy
- Where
- 9 sites in Sweden
- Volunteers
- 254 people
- Sponsor
- Alexander Valdman
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.