Clinical trials: Rectum Neoplasm
Rectum Cancer
Bacteriological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
The primary purpose of this study is to compare the differences of bacteriological in rectal cancer patients undergoing laparoscopic or transanal endoscopy radical resection.
- Trial name
- NCT05201872
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Yanhong Deng
Colon and Rectal Cancer
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
This study is being conducted to find out if treatment with gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab can shrink previously inoperable tumors enough for surgery.
- Trial name
- GAP Cemi (NCT07433673)
- Testing
- Cemiplimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Rectal Neoplasms, Colostomy Stoma
Pseudo Continent Perineal Colostomy vs Permanent Left Iliac Colostomy After Abdominoperineal Resection for Ultra Low Rectal Adenocarcinoma
Aim of this study is to compare the cost-effectiveness and the quality of life in the 6 months following the surgery of a pseudo continent perineal colostomy (PCPC) and a permanent left iliac colostomy (PLIC) following an…
- Conditions
- Rectal Neoplasms, Colostomy Stoma, Quality of Life
- Trial name
- NCT04141566
- Testing
- Perineal pseudocontinent colostomy, Permanent left iliac colostomy
- Where
- Morocco
- Volunteers
- 35 people
- Sponsor
- Moroccan Society of Surgery
Low Anterior Resection Syndrome
Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial
Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are…
- Trial name
- NCT05682157
- Testing
- Paula Method of muscle exercises
- Where
- 2 sites in Israel
- Volunteers
- 62 people
- Sponsor
- Hadassah Medical Organization
Rectal Cancer, Advanced Solid Tumor
Neoadjuvant Short-Course Radiotherapy Followed by CAPOX Plus PD-1 Antibody and IL-2 in Locally Advanced Rectal Cancer (PRIDE01)
A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy Followed by Sequential Immunotherapy with CAPOX Combined with PD-1 antibody and IL-2 for Locally Advanced Rectal Cancer
- Trial name
- NCT06577194
- Testing
- Sintilimab + IL-2 Combined with CAPOX, Short-course radiotherapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Rectal Cancer
Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
The treatment protocol proposed in this study is to perform short-term radiation therapy and 4 cycles of FOLFOX chemotherapy for neoadjuvant treatment of locally advanced rectal cancer.
- Trial name
- SOLAR (NCT05673772)
- Testing
- short-course radiotherapy, mFOLFOX6, Chemoradiotherapy
- Where
- 9 sites in South Korea
- Volunteers
- 364 people
- Sponsor
- Kyungpook National University Hospital
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fluorouracil and leucovorin calcium, work in different ways to stop the growth…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00942266
- Testing
- fluorouracil, leucovorin calcium, vorinostat
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Roswell Park Cancer Institute
Rectal Cancer, Colon Cancer
Learning Curve of SILS in CRC
Based on the data analysis of the General Surgery Department (Northern Department) of Ruijin Hospital from December 2013 to June 2021, we conducted a retrospective cohort study.
- Conditions
- Rectal Cancer, Colon Cancer, Single Port Laparoscopy
- Trial name
- SILS (NCT07736131)
- Volunteers
- 280 people
- Sponsor
- Ruijin Hospital
Rectal Cancer, Gender
Gender Differences in Robotic Surgery for Rectal Cancer: a Retrospective Study
Objective: To investigate gender-based differences in outcomes following robotic surgery for rectal cancer. Methods: A retrospective study was conducted on 155 patients (82 males, 73 females) who underwent robotic surgery for…
- Conditions
- Rectal Cancer, Gender, Complication,Postoperative, Surgery-Complications
- Trial name
- NCT06391060
- Testing
- Impact of Gender on Davinci rectal surgery
- Where
- China
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Daorong Wang
Cancer
PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer
RATIONALE: PV701 may be able to kill tumor cells while leaving normal cells undamaged. PURPOSE: Phase I trial to study the effectiveness of PV701 in treating patients who have advanced or recurrent ovarian epithelial, fallopian…
- Trial name
- NCT00055705
- Testing
- PV701
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Almost-cCR, Surgery
Comparison of Short-term Efficacy and Long-term Prognosis for Reduction Surgery and Radical Resection in Almost-cCR Rectal Cancer Patients
The aim of this study is evaluate the effect of two different surgical treatment on lower rectal cancer after almost clinical complete response(almost-cCR).
- Conditions
- Almost-cCR, Surgery, Rectal Cancer
- Trial name
- NCT03431428
- Testing
- transanal surgery, Miles surgery, Preoperative chemoradiotherapy
- Where
- China
- Volunteers
- 477 people
- Sponsor
- Zhang Rui
Colorectal Cancer
Radiation Therapy Plus Irinotecan in Treating Patients With Colon Cancer
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003344
- Testing
- irinotecan hydrochloride, radiation therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Rectal Cancer, Neoadjuvant Therapy
A Prospective Study of Expression Profiling-based Assessment of the Efficacy of Neoadjuvant Therapy for Rectal Cancer
This is a prospective study of expression profiling-based assessment of the efficacy of neoadjuvant therapy for rectal cancer.
- Trial name
- NCT06746298
- Volunteers
- 118 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Rectal Cancer
Application of Amide Proton Transfer-Weighted Imaging in Predicting Pathological Complete Response After Neoadjuvant Therapy of Rectal Cancer
The goal of this observational study is to learn about the amide proton transfer-weighted imaging for rectal cancer response assessment after neoadjuvant therapy.
- Trial name
- NCT06719414
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Locally Advanced Rectal Cancer
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer
The current trial is evaluating the impact of deep regional hyperthermia on the pathological complete response rate in locally advanced rectal cancer in the context of preoperative 5FU based radiochemotherapy.
- Conditions
- Rectal Cancer, Locally Advanced Rectal Cancer, Hyperthermia, Hyperthermic Radiochemotherapy
- Trial name
- HT01 (NCT02353858)
- Testing
- Deep regional hyperthermia, Radiotherapy, Chemotherapy (5-Fluorouracil)
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- University Hospital Tuebingen
Anal, Colon, and Rectal Cancers, Colorectal Neoplasms
Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer
To determine the maximum tolerated dose of Vandetanib with a current standard first-line chemotherapy regimen, capecitabine and oxaliplatin without and then with bevacizumab for the first line treatment of metastatic colorectal…
- Conditions
- Anal, Colon, and Rectal Cancers, Colorectal Neoplasms, Colon/Rectal Cancer
- Trial name
- NCT00532909
- Testing
- Vandetanib, Capecitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Branimir Sikic
Rectal Cancer Stage II, Rectal Cancer Stage III
Application of MRI in Identifying Myelosuppression Risk of Neoadjuvant Chemoradiotherapy for Rectal Cancer
Rectal cancer patients who received neoadjuvant chemoradiotherapy in Peking University Third Hospital in 2021 are divided into acute myelosuppression group, chronic myelosuppression group and normal group.
- Trial name
- NCT04970498
- Testing
- MRI, blood routine test
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Colorectal Cancer, Cancer-related Fatigue
Study on Fatigue in Colorectal Cancer Survivors, a Lifestyle Intervention
The SoFiT study is a randomized controlled trial examining the effects of a behaviour change guided lifestyle intervention on increasing adherence to the World Cancer Research Fund cancer prevention guidelines, compared to the…
- Conditions
- Colorectal Cancer, Cancer-related Fatigue, Colon Cancer, Rectal Cancer
- Trial name
- SoFiT (NCT05390398)
- Testing
- Behaviour change guided lifestyle intervention
- Where
- Netherlands
- Volunteers
- 161 people
- Sponsor
- Wageningen University
Colorectal Cancer, Metastatic Cancer
Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells.
- Trial name
- NCT00030563
- Testing
- irinotecan hydrochloride, adjuvant therapy, conventional surgery
- Where
- 3 sites in United States, Canada
- Sponsor
- University of Washington
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer
Monoclonal antibodies, such as pertuzumab and cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00551421
- Testing
- pertuzumab, cetuximab, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
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