Clinical trials: Recurrence of Atrial Fibrillation
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation
This study aims to examine the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation patients using different ablation strategies such as : (i) pulmonary vein antrum isolation (PVAI) + isolation of…
- Trial name
- TANTRA (NCT01672138)
- Testing
- Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
Predictors for Recurrence of Atrial Fibrillation After Electrical Cardioversion
In patients with persistent atrial fibrillation (AF), electrical cardioversion is very effective in restoring sinus rhythm if modern, biphasic cardioverters are used.
- Trial name
- PRE-ELECTRIC (NCT03346863)
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- Vestre Viken Hospital Trust
Atrial Fibrillation
Apple Watch-led Surveillance of AF Recurrence After Catheter Ablation
Atrial fibrillation (AF) is a heart rhythm disorder associated with debillitating symptoms, psychological distress and heart failure. It can also significantly increase an individuals stroke risk.
- Trial name
- AFFU-AW (NCT05016791)
- Testing
- Apple Watch-based heart rhythm monitoring
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Correlation of Atrial Fibrillation Recurrence After Bipolar Radiofrequency Ablation With microRNA Expression
The recurrence rate of atrial fibrillation (AF) after bipolar radiofrequency ablation was about 30%. Besides the factors, left atrium diameter, the duration of AF, NT-proBNP, and ejection fraction(EF), some studies demonstrated…
- Trial name
- NCT04134793
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Atrial Fibrillation
Prospective Cohort Study of the Risk of Recurrent Atrial Fibrillation After Radiofrequency Ablation
In this study, the continuous inclusion of atrial fibrillation patients treated by catheter ablation in the Department of Cardiology, Peking University Third Hospital, through the collection of clinical data and outpatient…
- Trial name
- NCT05638841
- Testing
- After radiofrequency ablation of atrial fibrillation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Cryptogenic Stroke, Atrial Fibrillation
Stroke of Unknown Cause in Women: The Impact of Long-term Heart Monitoring on Stroke Recurrence
The goal of this observational study is to investigate sex - differences in detection rate of atrial fibrillation after cryptogenic stroke (embolic stroke of unknown cause) - using an implantable cardiac rhythm monitor - and the…
- Conditions
- Cryptogenic Stroke, Atrial Fibrillation, Implantable Cardiac Monitor, Secondary Stroke Prevention
- Trial name
- STROKEWISE (NCT07194811)
- Where
- Norway
- Volunteers
- 1,400 people
- Sponsor
- University Hospital, Akershus
BTKi-induced Atrial Fibrillation, Hematologic Malignancy
IRAF-ABLATION Study: a Multicenter International Retrospective Cohort of Patients With BTK Inhibitors-related AF Treated by Catheter Ablation
Targeted anticancer drugs have completely changed the prognosis of malignancies during the past decades. Patients suffering from malignancies live longer and this allows adverse events of anticancer drugs to emerge, notably…
- Conditions
- BTKi-induced Atrial Fibrillation, Hematologic Malignancy, Atrial Fibrillation Catheter Ablation
- Trial name
- NCT06130709
- Testing
- Atrial fibrillation catheter ablation in a population of BTKi-induced atrial fibrillation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation Paroxysmal
Clinical and Electrophysiological Predictors of Arrhythmic Recurrence in Patients With Paroxysmal AF Undergoing First Ablation Procedure of AF by Pulmonary Vein Isolation
From the literature, the success rate (i.e., absence of AF recurrence) of ablation in cases of paroxysmal AF at one year changes between 70 and 85 percent. This rate is considered suboptimal.
- Trial name
- PREDICTORS (NCT06085014)
- Testing
- Standard of care, Data collection
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Centro Cardiologico Monzino
Atrial Fibrillation
Safety Monitoring of Patients Having Pulmonary Vein Ablation
Subjects eligible for this study have an irregular heartbeat called atrial fibrillation (AF)and who are scheduled for a procedure that involves applying electrical energy in your pulmonary veins, which is usually the site where…
- Trial name
- ROTEA (NCT00590668)
- Testing
- Transesophageal Echocardiography
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The Cleveland Clinic
First Ablation of Atrial Fibrillation
Predictive Value of Aortic Stiffness on Recurrence of Atrial Fibrillation After Disconnection of Pulmonary Veins (VARIABLE).
The ablation of atrial fibrillation (FA) by disconnection of pulmonary veins is a burgeoning intervention. It allows a long-term treatment of this arrhythmia with a success rate of about 80%.
- Trial name
- VARIABLE (NCT03226639)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation
Evaluation of Predictive Factors for Recurrence of Persistent Atrial Fibrillation After Ablation
This is a single-center, retrospective, observational study based on data extracted from the medical records of patients who underwent a procedure for persistent atrial fibrillation ablation.
- Trial name
- FAIR (NCT06620575)
- Testing
- Atrial fibrillation ablation
- Where
- France
- Volunteers
- 542 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Paroxysmal Atrial Fibrillation
Added Value of SVC Isolation in Patients With Pulmonary Vein Reconnection Undergoing Repeat Ablation for Recurrent Paroxysmal AF
Redo procedures after CLOSE-guided pulmonary vein isolation (PVI) for atrial fibrillation (AF) occur in 10% of patients. In case of pulmonary vein (PV) reconnection, electrophysiologists may re-isolate the pulmonary veins with or…
- Trial name
- RECONNECT (NCT04602169)
- Testing
- PVI, PVI + SVC
- Where
- Belgium
- Volunteers
- 108 people
- Sponsor
- AZ Sint-Jan AV
Atrial Fibrillation Paroxysmal, Recurrence
Early Recurrences of Atrial Arrhythmias and Their Impact on Late Recurrence After Pulmonary Vein Isolation With Pulsed Field Ablation of Paroxysmal Atrial Fibrillation
This is a prospective, single-arm study conducted in University Hospital of Split, Department of Cardiology. Patients treated with PFA for symptomatic paroxysmal atrial fibrillation will be asked to participate in the study.
- Trial name
- NCT05328882
- Testing
- Monitoring of paroxysmal atrial fibrillation recurrence after pulsed field catheter ablation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University of Split, School of Medicine
Atrial Fibrillation, Deep Vein Thrombosis
An Observational Post-Authorization Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®).
This study aims to evaluate the use of rivaroxaban and its short term safety when used by patients for the new indications of prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, treatment…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- ROSE (NCT01871194)
- Where
- United Kingdom
- Volunteers
- 3,400 people
- Sponsor
- Professor Saad Shakir
Atrial Fibrillation, Atrial Flutter
Therapy of Atrial Flutter by Afib Ablation
Ablation of the cavotricuspid isthmus (CTI) in the right atrium is currently the therapy of choice for the treatment of typical atrial flutter (3,4). It is a curative approach and has a high success rate (5).
- Trial name
- TripleA (NCT02051621)
- Testing
- Antiarrhythmic drug, Cavo-tricuspid-isthmus-ablation, Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Rostock
Atrial Fibrillation, Catheter Ablation
Efficacy of Pulmonary Vein Isolation Alone in Patients With Persistent Atrial Fibrillation
This study examines non-inferiority of pulmonary vein isolation (PVI) for persistent atrial fibrillation (AF) to extensive ablation; and reveals the effect of the presence or origin of AF trigger on outcomes of catheter ablation.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Recurrence
- Trial name
- EARNEST-PVI (NCT03514693)
- Testing
- PVI, PVI plus additional ablation
- Volunteers
- 512 people
- Sponsor
- Osaka Cardiovascular Conference
Atrial Fibrillation, Obesity & Overweight
Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients
Obese patients with atrial fibrillation (AF) have a high recurrence rate after catheter ablation, even at experienced centers. Weight reduction improves post-ablation outcomes, but lifestyle measures alone are difficult to…
- Conditions
- Atrial Fibrillation, Obesity & Overweight, Catheter Ablation
- Trial name
- TEAR-AF (NCT07715929)
- Testing
- Tirzepatide, Structured Lifestyle Intervention
- Volunteers
- 710 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation (AF), Ablation Treatment
Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients
This is a multicenter, open-label, superiority randomized controlled trial enrolling adult patients aged 18 to 75 years. All participants have abdominal obesity (BMI ≥ 28 kg/m² with specific waist circumference standards) and…
- Conditions
- Atrial Fibrillation (AF), Ablation Treatment, Obesity & Overweight, Mazdutide
- Trial name
- MOTIVE-AF (NCT07897305)
- Testing
- Mazdutide, Conventional treatment
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing Anzhen Hospital
Paroxysmal Atrial Fibrillation
TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation
This clinical investigation is intended to demonstrate the acute safety and effectiveness of ablation with the TactiCath™ Contact Force Ablation Catheter, Sensor Enabled™ (TactiCath SE) for the treatment of drug refractory…
- Trial name
- TactiSense (NCT03354663)
- Testing
- TactiCath SE
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 156 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Recurrence
Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice with a prevalence reaching 5% in patients older than 65 years and an incidence that increases progressively with age.1 According to the most recent…
- Trial name
- PRESERVE-SR (NCT03162120)
- Testing
- Ranolazine plus Metoprolol Combination, FlecainidE pluS Metoprolol Combination
- Sponsor
- Elpen Pharmaceutical Co. Inc.