Clinical trials: Recurrence of Atrial Fibrillation
Persistent Atrial Fibrillation
FIH Study of PFLotus in Persistent Atrial Fibrillation
Single-shot pulsed-field ablation (PFA) catheters maximize pulmonary vein isolation (PVI) efficiency but are limited for focal or linear ablation.
- Trial name
- PFLotus- FIH (NCT07301190)
- Testing
- Pulse field ablation with the PFLotus catheter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Third People's Hospital of Chengdu
Persistent Atrial Fibrillation
Renal Denervation Combined With Pulsed Field Ablation to Prevent Recurrence in Persistent Atrial Fibrillation
The goal of this clinical trial is to learn whether adding renal denervation (RDN) to pulsed-field ablation (PFA) reduces recurrence of atrial tachyarrhythmias in adults (≥18 years) with persistent atrial fibrillation undergoing…
- Trial name
- OFF-MED (NCT07320768)
- Testing
- renal denervation, Pulsed-Field Ablation (PFA)
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Cardiac Rehab Post-atrial Fib Ablation
The aim of this study is to examine the effect of a 12-week exercise-based cardiac rehabilitation intervention on the recurrence of atrial fibrillation (AF) in patients at six- and twelve-months post-ablation procedure.
- Trial name
- NCT05450731
- Testing
- 12-week supervised exercise based cardiac rehabilitation program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- MultiCare Health System Research Institute
Atrial Fibrillation
Evaluation of Recurrence Risk of Atrial Fibrillation After Cryoballoon Ablation
The recurrence of atrial fibrillation(AF) after pulmonary vein ablation with cryoballoon is conducted by many factors . The previous studies found larger left atrial and longer AF duration are tied to higher risk of AF…
- Trial name
- era-cryo (NCT05492760)
- Testing
- cryoballoon ablation
- Volunteers
- 600 people
- Sponsor
- Shanghai 10th People's Hospital
Atrial Fibrillation
Relationship Between Fibroblast Growth Factor 23 and Recurrence of Atrial Fibrillation After Catheter Ablation
To investigate whether fibroblast growth factor 23 can be used to predict recurrence after catheter ablation for atrial fibrillation and to provide an objective basis for the clinical selection of the optimal patients for…
- Trial name
- REBECCA (NCT02958839)
- Testing
- Catheter ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Atrial Fibrillation
AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial Fibrillation
Randomized trial of low-dose amiodarone therapy versus catheter ablation (CA) in older patients with persistent atrial fibrillation (AF).
- Trial name
- AmioCAAF (NCT02341105)
- Testing
- Catheter ablation, Amiodarone
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
The Use of DIOVAN to Reduce Post-Cardioversion Recurrence of Atrial Fibrillation Trial (the DRAFT Trial)
24 week, single center, prospective, randomized, double-blind treatment study of valsartan (80 mg/bid, increased to 160 mg/bid) or placebo in addition to other general medical therapy in patients with persistent atrial…
- Trial name
- NCT00343499
- Testing
- valsartan
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Atrial Fibrillation
Does Cardiac Rehabilitation Reduce the Risk of Recurrence of Atrial Fibrillation Following the First Catheter Ablation?
Many risk factors contribute to the onset of atrial fibrillation. This study is specifically concerned with the effect of addressing these risk factors by cardiac rehabilitation on the risk of recurrence of atrial fibrillation…
- Trial name
- NCT03389633
- Testing
- rehabilitation
- Volunteers
- 462 people
- Sponsor
- prof. dr. Paul Dendale
Atrial Fibrillation New Onset
Atrial Fibrillation Occurring Transiently With Stress (AFOTS)
Rationale Atrial fibrillation (AF) often occurs transiently in the setting of an acute stressor (e.g. medical illness or surgery).
- Trial name
- AFOTS (NCT03221777)
- Testing
- 14 Day ECG Patch (Zio XT Patch, iRhythm Technologies)
- Where
- 3 sites in Canada
- Volunteers
- 281 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation, Recurrence
Impact of Short-course Colchicine Versus Placebo After Pulmonary Vein Isolation (IMPROVE-PVI Pilot)
Recurrence is a common problem after catheter ablation for atrial fibrillation, affecting at least one out of three patients. Inflammation due to the procedure may contribute to pulmonary vein reconnection and, thus, failure of…
- Trial name
- NCT04160117
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF
This is a prospective multicenter clinical study comparing the efficacy of the Apple Watch AFib History tool to the iRhythm Zio Patch monitoring device in quantifying atrial fibrillation (AF) burden after surgical ablation.
- Trial name
- STARBURST-AF (NCT07122947)
- Testing
- Apple Watch: AFib History, Zio Patch
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- The Cleveland Clinic
Persistent Atrial Fibrillation
Study on the Prevention of Atrial Fibrillation Recurrence After Ablation by Qidong Yixin Granule
The goal of this clinical trial is to investigate the efficacy and safety of Qidong Yixin Granules in preventing recurrence in patients after radiofrequency catheter ablation for atrial fibrillation.
- Trial name
- QDYX-AF (NCT07508618)
- Testing
- Qi Dong Yi Xin Granules
- Where
- 5 sites in China
- Volunteers
- 846 people
- Sponsor
- Sir Run Run Shaw Hospital
Atrial Fibrillation
Dronedarone Pattern of Use in Patients Scheduled for Elective Cardioversion (ELECTRA)
Primary Objective: To determine whether daily administration of dronedarone started 5-7 days before cardioversion is superior to dronedarone started only after cardioversion with respect to the absence of symptomatic, ECG…
- Trial name
- NCT01026090
- Testing
- Dronedarone
- Where
- 43 sites in Canada
- Volunteers
- 292 people
- Sponsor
- Sanofi
Atrial Fibrillation
Strategy of Crossing Two Ablation Techniques (Cryoballoon and Radiofrequency) After the Recurrence of Paroxysmal AF and the Need for a New Procedure
Randomized phase III clinical trial to compare the efficacy of the two most widely used ablation techniques (cryotherapy and radiofrequency) after recurrence of atrial fibrillation (AF) in patients requiring a new ablation…
- Trial name
- X-TRA (NCT04877327)
- Testing
- Ablation
- Where
- 9 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Galaxia Empírica
Atrial Fibrillation
Atrial Electromechanical Interval and Pulse Wave Velocity in the Prediction of Recurrence of Atrial Fibrillation
This study aims to evaluate the utility of the atrial electromechanical interval and pulse wave velocity in the prediction of recurrence of atrial fibrillation among patients who underwent successful direct current cardioversion…
- Trial name
- APPRAISE (NCT00818012)
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Creighton University
Atrial Fibrillation
Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is an abnormal heart rhythm in which the top chambers of the heart beat very fast. AF catheter ablation is a known technique to convert heart rhythm from AF to normal rhythm.
- Trial name
- AWARE (NCT02150902)
- Testing
- Wide area circumferential catheter ablation, Augmented- wide area circumferential ablation procedure
- Where
- 11 sites in Canada
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Stroke, Paroxysmal Atrial Fibrillation
Paroxysmal Atrial Fibrillation in Patients With Acute Ischemic Stroke
The purpose of this study is to estimate the clinical relevance of monitoring patients with acute ischemic stroke with 48 hours' inpatient cardiac telemetry in relation to evaluate the presence of brief runs of premature atrial…
- Conditions
- Ischemic Stroke, Paroxysmal Atrial Fibrillation, Premature Atrial Complexes
- Trial name
- NCT02610803
- Where
- Denmark
- Volunteers
- 863 people
- Sponsor
- Odense University Hospital
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Atrial Fibrillation, Persistent, Blood Pressure
Effect of Blood Pressure on Cardiovascular Outcomes and Recurrence After Catheter Ablation in Patients With Atrial Fibrillation
Effect of blood pressure on cardiovascular outcomes and recurrence after catheter ablation in patients with atrial fibrillation
- Trial name
- AF BP (NCT06433336)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Lanzhou University Second Hospital
Atrial Fibrillation
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
The proposed studies will test this hypothesis by randomizing patients with AF to 2-HOBA or placebo 7 days prior to AF ablation to allow 2-HOBA to reach steady-state levels.
- Trial name
- NCT04433091
- Testing
- 2-Hydroxybenzylamine
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center