Clinical trials: Recurrence of Atrial Fibrillation
Persistent Atrial Fibrillation
Acupuncture in Persistent Atrial Fibrillation
The aim of this trial is to evaluate the effect of acupuncture on prevention of atrial fibrillation (AF) recurrence after electrical cardioversion (EC) for persistent AF patients resistant to the antiarrhythmic drugs (AADs).
- Trial name
- NCT02110537
- Testing
- Active Acupuncture, flecainide
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kyunghee University Medical Center
First Ablation of Atrial Fibrillation
Predictive Value of Aortic Stiffness on Recurrence of Atrial Fibrillation After Disconnection of Pulmonary Veins (VARIABLE).
The ablation of atrial fibrillation (FA) by disconnection of pulmonary veins is a burgeoning intervention. It allows a long-term treatment of this arrhythmia with a success rate of about 80%.
- Trial name
- VARIABLE (NCT03226639)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Fibrillation, Atrial
Evaluation of Efficacy and Safety of Lovaza (Omega-3-Acid Ethyl Esters) in Recurrent, Symptomatic Atrial Fibrillation
The purpose of this study is to evaluate efficacy and safety of Omacor (omega-3-acid ethyl esters) in patients with recurrent, symptomatic atrial fibrillation.
- Trial name
- NCT00402363
- Testing
- omega-3-acid ethyl esters
- Where
- 178 sites in United States
- Volunteers
- 663 people
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation
Efficacy of Dapagliflozin on Recurrence After Catheter Ablation for Atrial Fibrillation
This is a single-center, parallel-group, randomized, open-label trial evaluating the effect of 3-month treatment with dapagliflozin 10mg once daily on the recurrence of atrial fibrillation after catheter ablation for atrial…
- Trial name
- DARE-AF (NCT06433479)
- Testing
- Dapagliflozin 10 mg per day for 3 months after initial catheter ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF
There is substantial evidence linking inflammation to the initiation and perpetuation of AF. Although the precise mechanism by which inflammation contributes to the development of AF remains unclear, it has been proposed that…
- Trial name
- COPPER-AF (NCT02582190)
- Testing
- Colchicine group
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Atrial Fibrillation
Strategy of Crossing Two Ablation Techniques (Cryoballoon and Radiofrequency) After the Recurrence of Paroxysmal AF and the Need for a New Procedure
Randomized phase III clinical trial to compare the efficacy of the two most widely used ablation techniques (cryotherapy and radiofrequency) after recurrence of atrial fibrillation (AF) in patients requiring a new ablation…
- Trial name
- X-TRA (NCT04877327)
- Testing
- Ablation
- Where
- 9 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Galaxia Empírica
Recurred Atrial Fibrillation
Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for repeat ablation procedure among the patients with recurred atrial fibrillation after de novo catheter ablation.
- Trial name
- NCT02747498
- Testing
- Procedure with circumferential pulmonary vein isolation, Procedure with linear ablation in addiction to pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Investigation of Substrates Associated With the Recurrence of Atrial Fibrillation After PV Cryoablation
The two main mechanisms for atrial fibrillation (AF) recurrence after cryoablation include Pulmonary vein (PV) reconnection and the presence of non-PV associated arrhythmic focuses.
- Trial name
- SubstrateAF (NCT03587181)
- Testing
- Cryoablation of the pulmonary veins and myocardial biopsy
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Research Center for Preventive Medicine
Atrial Fibrillation
Artificial Intelligence Models to Predict Clinically Relevant Cardiovascular Outcomes
Atrial fibrillation (AF) is a frequent and clinically relevant problem among the events that may occur during the hospitalization period in patients with cardiovascular disease.
- Trial name
- PERCARD (NCT06847100)
- Testing
- Blood withdrawal
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 273 people
- Sponsor
- Centro Cardiologico Monzino
Atrium; Fibrillation, Atrium; Flutter
Refralon in Patients With Recurrence Paroxysmal and Persistent Forms of Atrial Fibrillation Who Underwent Catheter Ablation
It is planned to evaluate the efficacy and safety of the class III antiarrhythmic drug refralon as a drug for pharmacological cardioversion in patients with recurrent atrial fibrillation (AF) and atrial flutter (AFL) after…
- Trial name
- NCT05456204
- Testing
- Pharmacological cardioversion with Refralon
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Long Standing Persistent Atrial Fibrillation
Remote Monitoring of AF Recurrence Using mHealth Technology
Atrial fibrillation (AF) is the most common arrhythmia worldwide. It carries a significant health burden, conferring on sufferers a reduction in quality of life, risk of significant morbidities such as stroke and heart failure…
- Trial name
- REMOTE-AF (NCT05037136)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Obstructive Sleep Apnea, Atrial Fibrillation
Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients
With this pilot study, we are hoping to test the feasibility of a larger study in the future and to learn whether positive airway pressure therapy reduces the recurrence risk of atrial fibrillation after successful catheter…
- Trial name
- OSA-AFIB (NCT03242720)
- Testing
- Cardiac Ablation for Atrial Fibrillation
- Where
- United States
- Sponsor
- Stanford University
Persistent Atrial Fibrillation
Clinical Outcomes of Persistent Atrial Fibrillation Ablation Using Ablation Index-guided Radiofrequency Catheter Ablation in Patients With Continuous Monitoring
Atrial fibrillation (AF) is the commonest condition affecting the rhythm of the heart. Tablets to try to normalize the heart rhythm rarely work well.
- Trial name
- AF-FAIR-MONTOR (NCT05406310)
- Testing
- Ablation Index-guided ablation, High-power, short-duration ablation using QDOT Micro catheter
- Sponsor
- St. Louis University
Atrial Fibrillation
Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation
A randomized, double-blinded, placebo-controlled study to evaluate the effect of spironolactone in addition to conventional treatment compared with placebo in patients with paroxysmal and persistent atrial fibrillation with…
- Trial name
- INSPIRE-AF (NCT02764619)
- Testing
- Spironolactone
- Where
- Denmark
- Volunteers
- 125 people
- Sponsor
- Svendborg Hospital
Atrial Fibrillation, Atrial Inflammation
Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation Ablation
FIBRO-RISK study aims to investigate the impact of inflammatory-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation.
- Trial name
- FIBRO-RISK (NCT03757741)
- Testing
- Cardiac imaging tests, Venous blood samle collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Atrial Fibrillation (AF), Mitral Regurgitation
The Multi-center Study of Comprehensive Atrial Fibrillation Regurgitation and Recurrent Events Evaluation
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic and can lead to valve regurgitation and a poor prognosis.
- Conditions
- Atrial Fibrillation (AF), Mitral Regurgitation, Tricuspid Regurgitation
- Trial name
- NCT07085650
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Hospital of China Medical University
Atrial Fibrillation and Flutter, Atrial Arrhythmia
Development of a New Impedance Mapping System for Ablation of Atrial Arrhythmias in Patients
Precise identification of the atrial fibrosis is essential for successful catheter ablation of atrial arrhythmias in patients with atrial fibrillation.
- Conditions
- Atrial Fibrillation and Flutter, Atrial Arrhythmia, Atrial Fibrillation Recurrent
- Trial name
- NCT05159180
- Testing
- cardioz mapping
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Atrial Fibrillation, Recurrence
Impact of Short-course Colchicine Versus Placebo After Pulmonary Vein Isolation (IMPROVE-PVI Pilot)
Recurrence is a common problem after catheter ablation for atrial fibrillation, affecting at least one out of three patients. Inflammation due to the procedure may contribute to pulmonary vein reconnection and, thus, failure of…
- Trial name
- NCT04160117
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patients undergoing pulmonary vein…
- Trial name
- SPECULATE (NCT01173809)
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation