Clinical trials: Recurrent Abortion
Recurrent Pregnancy Loss
Genomic Predictors of Recurrent Pregnancy Loss
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
- Trial name
- GPRPL (NCT05444283)
- Where
- 10 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Insulin Resistance
Insulin Resistance in Recurrent Miscarriage
The objective of this study is to study the association between insulin resistance and recurrent spontaneous miscarriage (RSM).
- Trial name
- IRRM (NCT02705248)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Infertility, Recurrent Miscarriage
Effect of Influenza Vaccination on Donor Egg Recipient Outcomes
In this study the investigators propose a randomized controlled trial to evaluate the effect of influenza vaccination on clinical pregnancy rates among women undergoing in vitro fertilization as donor egg recipients.
- Trial name
- DE-FluVac (NCT02946177)
- Testing
- Influenza Vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Recurrent Pregnancy Loss
Treatment of Recurrent Pregnancy Loss Using Mesenchymal Stem Cells
Treatment of Recurrent pregnancy loss using mesenchymal stem cells capable of differentiation in the endometrial-decidual direction.
- Trial name
- NCT05520112
- Testing
- Mesenchymal stem cells capable of differentiation in the endometrial-decidual direction, Standard treatment according to the clinical protocols
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Recurrent Pregnancy Loss, Unexplained Infertility
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo…
- Trial name
- NCT03401918
- Testing
- Uterine ERA and microbiome testing, Oral antibiotics and vaginal probiotics
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Stanford University
Vitamin D Deficiency, Recurrent Miscarriage
The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome
The objective of this single-center prospective observational study is to clarify the trend of maternal serum 25(OH)D levels before pregnancy and during pregnancy, and to explore the correlation between serum 25(OH)D levels and…
- Conditions
- Vitamin D Deficiency, Recurrent Miscarriage, Pregnancy Related
- Trial name
- NCT05824897
- Testing
- Serum levels of vitamin D
- Where
- China
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Abortion, Recurrent
Platelet Indices and Recurrent Pregnancy Loss
The aim of this study was to evaluate relationship between platelet indices, red blood cell indices and recurrent pregnancy loss.
- Trial name
- NCT05190796
- Testing
- platelet indices
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia University
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility, Recurrent Pregnancy Loss
Microfluidics Versus Gradient Centrifugation Effect on Euploidy Rates
This research is being done to determine if using a microfluidics chamber, a device used to process sperm, will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information)…
- Trial name
- NCT04744025
- Testing
- Microfluidics chamber, Density Gradient Centrifugation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Lawrence Engmann
vitD3 Level in Cases of Recuurent Pregnancy Loss
Assesment of Vit D3 Level in Cases of Unexplaind Pregnancy Loss in Assiut
Assesment of Vit D3 leve in cases of unexplained recurrent pregnancy loss in assiut
- Trial name
- vitDinRPL (NCT03327766)
- Testing
- 4-Measurment of serum 25(OH)D3 using Vidas by ELFA meathod.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Recurrent Pregnancy Loss
Tender Loving Care for Recurrent Pregnancy Loss
The goal of this investigational study is to evaluate participation in a weekly, interactive, tender loving care messaging platform impact on pregnancy outcomes in patients with recurrent pregnancy loss.
- Trial name
- NCT06182878
- Testing
- Tender loving care intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Mutation
C677T Methylenetetrahydrofolate Reductase Mutation
To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.
- Trial name
- C677T (NCT05864937)
- Testing
- infertily evaluation
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Abortion, Habitual
LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss
The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate whether levothyroxine supplement improves pregnancy outcomes in women with recurrent pregnancy loss (RPL) and isolated maternal…
- Trial name
- LIGHT (NCT06999278)
- Testing
- Levothyroxin
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Acupuncture, Recurrent Spontaneous Abortion
The Effects of Acupuncture on the Natural Pregnancy in Patients With Recurrent Abortion
Recurrent spontaneous abortion (RSA) is a common pregnancy complication in women of reproductive age and the cause of RSA remains largely unclear. Acupuncture is widely used in clinical practice to treat infertility and abortion.
- Conditions
- Acupuncture, Recurrent Spontaneous Abortion, Ultrasound Therapy, Coagulation
- Trial name
- NCT05998421
- Testing
- acupuncture, routine aspirin and heparin treatment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Jianmei Xia
Infertility, Female, Abortion, Habitual
Effects of PGS in Infertile Female Patients With RPL
Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects about 1% of all couples and challenges both patients and clinicians technically and emotionally.
- Trial name
- NCT02223221
- Testing
- IVF/ICSI, PGS, Without PGS
- Where
- China
- Volunteers
- 189 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Recurrent Pregnancy Losses
The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage
The aim of the study is to evaluate the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal…
- Trial name
- NCT01688284
- Testing
- office hysteroscopy
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Abortion, Habitual
RECAB-ASA; Treatment of Recurrent Abortion With Aspirin
The aim of this study is to examine whether treatment with 75 mg aspirin daily compared with placebo could reduce the risk for a new miscarriage.
- Trial name
- RECAB-ASA (NCT02823743)
- Testing
- Aspirin
- Volunteers
- 400 people
- Sponsor
- Göteborg University