Clinical trials: Recurrent Acute Pancreatitis
Acute Pancreatitis, Recurrent Acute Pancreatitis
Preventing the Recurrence of Acute Pancreatitis by Alcohol and Smoking Cessation
Recurrence of acute pancreatitis (AP) is often facilitated by regular alcohol consumption and smoking. An applied lifestyle intervention focusing on the cessation of alcohol consumption and smoking might prevent the recurrence of…
- Trial name
- REAPPEAR (NCT04647097)
- Testing
- Standard intervention only, Standard intervention plus repeated intervention
- Where
- Hungary
- Volunteers
- 364 people
- Sponsor
- University of Pecs
Pancreatitis, Pancreas Divisum
SpHincterotomy for Acute Recurrent Pancreatitis
The purpose of this study is to determine if a procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with sphincterotomy reduces the risk of pancreatitis or the number of recurrent pancreatitis episodes in…
- Conditions
- Pancreatitis, Pancreas Divisum, Pancreatitis, Acute, Pancreatitis Idiopathic
- Trial name
- SHARP (NCT03609944)
- Testing
- ERCP with miES, EUS
- Where
- 21 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- Oregon Health and Science University
Pancreatitis, Chronic, Pancreatitis, Acute
Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus
The purpose of this study is to evaluate efficacy of pioglitazone (PIO) versus empagliflozin (EMPA) to improve glycemic control in people with Chronic Pancreatitis (CP) or Recurrent Acute Pancreatitis (RAP) or Acute Pancreatitis…
- Conditions
- Pancreatitis, Chronic, Pancreatitis, Acute, Diabetes Mellitus
- Trial name
- PEP-DM (NCT06729996)
- Testing
- Pioglitazone (PIO), Empagliflozin (EMPA)
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Pancreatitis
Acute Pancreatitis and Acute Fluid Collections
The purpose of this study is to evaluate if percutaneous drainage of sterile fluid collections recurring after initial aspiration in acute pancreatitis yielded better results than their conservative management.
- Trial name
- NCT00786929
- Testing
- Catheter drainage, Conservative treatment
- Where
- Bosnia and Herzegovina
- Volunteers
- 63 people
- Sponsor
- University Medical Center, Tuzla
Pancreatitis, Chronic, Pancreatitis, Acute Recurrent
Internet-based Pain Self-management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Pain is the cardinal symptom of acute recurrent and chronic pancreatitis, and available medical treatments have limited efficacy.
- Trial name
- IMPACT (NCT03322644)
- Testing
- Internet-based CBT intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Seattle Children's Hospital
Acute Pancreatitis
Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis
This randomized phase II trial studies how well simvastatin works in reducing pancreatitis (the inflammation of the pancreas) in patients with pancreatitis that occurs more than once (recurrent), has worsened quickly (acute), or…
- Trial name
- NCT02743364
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatitis, Chronic, Pancreatitis, Acute
Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
The investigators will enroll a total of 628 patients under 18 years of age with ARP or CP. Included in the total are the 357patients in the INSPPIRE 1 database who are planned to be reenrolled under this protocol over the next 4…
- Trial name
- INSPPIRE 2 (NCT03672422)
- Testing
- Blood sample, Patient questionnaires, Saliva sample
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 623 people
- Sponsor
- Aliye Uc
Acute Pancreatitis Necrotizing
Impact of Transmural Plastic Stent on Recurrence of Pancreatic Fluid Collection After Metal Stent Removal in Disconnected Pancreatic Duct
Walled of necrosis (WON) is severe local complication of acute necrotizing pancreatitis. Disconnected pancreatic duct syndrome(DPDS) is commonly seen (50-60%) after necrotizing pancreatitis and has long term implication like…
- Trial name
- NCT03436043
- Testing
- Transmural Plastic stenting
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Asian Institute of Gastroenterology, India
Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis
GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis
Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is associated with a high risk of recurrence despite standard lipid-lowering therapy and lifestyle modification.
- Conditions
- Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis, Pancreatitis Relapsing, Hypertriglyceridemia
- Trial name
- RECAP-GLP1 (NCT07617155)
- Testing
- Semaglutide
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Peking Union Medical College Hospital
Ampullary Cancer, Duodenal Cancer
Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
Our institution performs therapeutic ERCP (Endoscopic retrograde cholangiopancreatography ), Endoscopic Ultrasound (EUS) and Interventional Endoscopy in around 1000 patients a year.
- Conditions
- Ampullary Cancer, Duodenal Cancer, Bile Duct Cancer, Bile Duct Disorders
- Trial name
- NCT01438385
- Testing
- Interventional Endoscopy
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Weill Medical College of Cornell University
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Acute Pancreatitis Due to Gallstones, Acute Pancreatitis
PrEveNtion of Biliary Events After Acute Pancreatitis in NonSUrgicaL PAtients: PENINSULA Trial
Acute pancreatitis (AP) is a common condition and its main etiology is biliary. Cholecystectomy is the standard preventive treatment for recurrence of AP after admission.
- Trial name
- PENINSULA (NCT06409741)
- Testing
- Biliary sphincterotomy
- Where
- 5 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Hospital General Universitario de Alicante
Idiopathic Acute Pancreatitis
Preventing Recurrent 'Idiopathic' Acute Pancreatitis Through Laparoscopic Cholecystectomy (PICUS-2)
Rationale: Annually, acute pancreatitis is diagnosed in 6,500 patients in the Netherlands. In up to 25% of patients no definitive cause can be determined after routine work-up including endoscopic ultrasound and this is deemed to…
- Trial name
- PICUS-2 (NCT06391359)
- Testing
- Laparoscopic cholecystectomy, Watchful waiting
- Where
- Netherlands
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- M.G. Besselink
Islet Cell Tumor, Pancreatic Cancer
Collecting Medical Information and Tissue Samples From Patients With Pancreatic Cancer or Other Pancreatic Disorders
RATIONALE: Gathering medical information and collecting and storing samples of blood and tissue to test in the laboratory may help doctors develop better ways to screen people at risk for pancreatic cancer or other pancreatic…
- Conditions
- Islet Cell Tumor, Pancreatic Cancer, Pancreatic Disease, Acute Pancreatitis
- Trial name
- NCT00830557
- Testing
- medical chart review, survey administration, biospecimen collection
- Where
- 3 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Mayo Clinic
Pancreatitis
Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the Pancreas
The purpose of this study is to evaluate the safety and effectiveness of RG1068 (synthetic human secretin) with MRCP in subjects with abnormalities of the pancreas.
- Trial name
- NCT00660335
- Testing
- RG1068 (synthetic human secretin)
- Volunteers
- 258 people
- Sponsor
- Repligen Corporation
Acute Pancreatitis
A Predictive Model for Recurrent Acute Pancreatitis
The goal of this observational study is to learn about recurrent acute pancreatitis (RAP) .The main questions it aims to answer are: 1. What are the risk factors for RAP? 2.
- Trial name
- NCT06464887
- Volunteers
- 659 people
- Sponsor
- Qinghao Wang
Benign Pancreatic Neoplasm, Chronic Pancreatitis
A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors
This phase I/II trial assesses the safety and effectiveness of total pancreatectomy with islet cell autotransplantation for the treatment of patients with long-term pancreatic inflammation (chronic pancreatitis) and non-cancerous…
- Conditions
- Benign Pancreatic Neoplasm, Chronic Pancreatitis, Recurrent Acute Pancreatitis
- Trial name
- NCT05453851
- Testing
- Pancreatectomy, Quality-of-Life Assessment, Treatment Planning
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- OHSU Knight Cancer Institute
Chronic Pancreatitis, Chronic Pain
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable.
- Trial name
- P-QST (NCT04996628)
- Testing
- Quantitative Sensory Test 1, Quantitative Sensory Test 2, Quantitative Sensory Test 3
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Chronic Pancreatitis, Chronic Pain
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic…
- Trial name
- NCT03434392
- Testing
- Quantitative Sensory Test 1, Quantitative Sensory Test 2, Quantitative Sensory Test 3
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Anna Evans Phillips
Pancreatitis, Chronic
Radiomic fEatures of Pancreas From Contrast Enhanced CT Image Predict One-Year RecUrrence Risk of Acute PancReatitis
One-year recurrence rate of acute pancreatitis at about 20%. 36% of the patients with recurrent acute pancreatitis will develop into chronic pancreatitis.
- Trial name
- RECUR (NCT05778929)
- Testing
- Radiomics Model
- Volunteers
- 694 people
- Sponsor
- Peking University People's Hospital