Clinical trials: Recurrent Depression, active
Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms
A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression
An 8-week, two-armed, randomized-controlled trial that examines the antidepressant effect of treatment with transcranial pulsed electromagnetic fields (T-PEMF) in patients diagnosed with moderate to severe depression using using…
- Conditions
- Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms, Recurrent Depressive Disorder, Current Episode Moderate, Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms
- Trial name
- NCT06005103
- Testing
- Treatment with MoodHeadBand (T-PEMF treatment)
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depression, Bipolar Disorder
Neuro-computational Study of Thymic Fluctuations in Mood Disorders
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders".
- Conditions
- Depression, Bipolar Disorder, Recurrent Depression, Mood Disorders
- Trial name
- MOODELING (NCT07033923)
- Testing
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional), Computerized cognitive tests, Daily longitudinal monitoring by mobile MOODELING application
- Where
- 2 sites in France
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression, Cost Benefit Analysis
Dysthymia: Associated Costs, Treatment and Change Process
The study evaluates cost and effect of inpatient versus outpatient treatment of dysthymia, as well as investigates the processes through which psychotherapy works in treating dysthymia.
- Conditions
- Depression, Cost Benefit Analysis, Psychotherapeutic Processes
- Trial name
- DFront (NCT04911829)
- Testing
- Psychotherapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Modum Bad
Major Depressive Disorder, Recurrent, in Remission
Light and Ion Maintenance In Treatment for Depression (LIMIT-D): Feasibility Study
Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to…
- Trial name
- NCT05423275
- Testing
- Negative ion therapy, Light therapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Depression - Major Depressive Disorder, Anxiety
Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer
The purpose of this randomized clinical trial is to study anxiety and depression symptoms at diagnosis in patients with colon cancer. Previous studies have shown that so-called.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Colon Cancer
- Trial name
- BAdepCa (NCT06745700)
- Testing
- Brief Behavioural Activation, Care as usual
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Västmanland
Major Depressive Disorder
EMA-Guided Maintenance TMS for Depression
The goal of this study is to evaluate the use of ecological-momentary-assessment (EMA) as a method for scheduling maintenance treatments for patients with Major Depressive Disorder (MDD) who responded to an initial acute course…
- Trial name
- NCT06145594
- Testing
- EMA Monitoring, Scheduling Maintenance TMS sessions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Butler Hospital
Ischemic Stroke, Acute
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differential organisms and…
- Trial name
- NCT06584565
- Testing
- microbiome; metabolomics; proteomics
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Stroke, Cardiovascular Diseases
MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway
Annually 13000 Norwegians experience an ischemic stroke. The number of stroke is anticipated to increase with 50% within 2030 due to a growing number of elderly.
- Conditions
- Stroke, Cardiovascular Diseases, Cardiovascular Risk Factor, Brain Ischemia
- Trial name
- NCT03962127
- Testing
- no intervention
- Where
- 8 sites in Norway
- Volunteers
- 800 people
- Sponsor
- Norwegian University of Science and Technology
Depression - Major Depressive Disorder, Depression Bipolar
Digital Phenotypes for Predicting Depression
This longitudinal study aims to identify and validate digital phenotypes that can predict recurrence of major depressive episodes using passively collected, real-time sensing data from smartphones and wearable devices.
- Conditions
- Depression - Major Depressive Disorder, Depression Bipolar, Bipolar Disorder (BD), Mood Disorders
- Trial name
- NCT07151846
- Where
- South Korea
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cognitive Behavioral Therapy
Fear of Recurrence and Stopping Immunotherapy
The study includes participants experiencing distress with regard to stopping immunotherapy and will utilize cognitive-behavioral therapy to reduce fear of recurrence, depression, and anxiety and improve quality of life.
- Trial name
- NCT04761328
- Testing
- cognitive behavioral therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Early-stage Breast Cancer, Fear of Cancer Recurrence
Psilocybin FCR Early-Stage Breast Cancer
This trial is designed to evaluate efficacy and psychological mechanisms of single-dose psilocybin-assisted psychotherapy (PAP) to treat fear of cancer recurrence (FCR), psychiatric (anxiety, depression) distress and…
- Conditions
- Early-stage Breast Cancer, Fear of Cancer Recurrence, Anxiety, Depression
- Trial name
- NCT07909408
- Testing
- Psilocybin 25 mg, Psilocybin 5 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Depressive Disorder, Anxiety Disorders
StayFine: Personalised Relapse Prevention of Anxiety and Mood Disorders in Youths
The current study examines the effectiveness of the StayFine app for relapse prevention of anxiety or depressive disorders in youth using a randomized controlled trial.
- Trial name
- StayFine (NCT05551468)
- Testing
- StayFine guided app-based personalised intervention modules, StayFine app-based monitoring
- Where
- Netherlands
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Ggz Oost Brabant
Fear of Cancer Recurrence, Cancer Survivors
Fighting the Fear of Cancer Recurrence in Cancer Survivors: A Pilot Study on the Effectiveness of Metacognitive Therapy
This study aims to evaluate the effectiveness of metacognitive therapy (MCT) in reducing fear of cancer recurrence (FCR) among cancer survivors. With advances in cancer treatment, more patients are surviving cancer.
- Conditions
- Fear of Cancer Recurrence, Cancer Survivors, Psychological Distress
- Trial name
- MCT-FCR (NCT07500168)
- Testing
- Metacognitive Therapy, Relaxation Therapy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Koo Foundation Sun Yat-Sen Cancer Center
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of…
- Trial name
- NCT05913960
- Testing
- accelerated intermittent theta burst stimulation, high frequency stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression, Depressive Disorder, Treatment-Resistant
OSU6162 as add-on in SSRI/SNRI-resistant Depression
This is a randomised, placebo-controlled, parallel-group trial comparing OSU6162 at flexible dosage with placebo as add-on to treatment with an SSRI/SNRI in patients with depression that have not responded to treatment with an…
- Conditions
- Depression, Depressive Disorder, Treatment-Resistant, Depressive Disorder, Depressive Episode
- Trial name
- ODEN (NCT05641623)
- Testing
- OSU6162
- Where
- 4 sites in Sweden
- Volunteers
- 180 people
- Sponsor
- Göteborg University
Aging, Depression
Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression.
- Conditions
- Aging, Depression, Cognitive Symptoms
- Trial name
- NCT07527273
- Testing
- Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild
Mindfulness-Based Cognitive Therapy (MBCT) for the Prevention of Depression Relapse or Recurrence Using Videoconference
Objectives: To evaluate the clinical- and cost-effectiveness of two delivery formats of mindfulness-based cognitive therapy (MBCT) - (i) MBCT delivered through eight videoconference group sessions (group MBCT), and (ii) MBCT…
- Conditions
- Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild, Major Depressive Disorder, Recurrent, Moderate
- Trial name
- BECOME (NCT06832605)
- Testing
- Group Mindfulness-Based Cognitive Therapy, Mindfulness-Based Cognitive Therapy Self-Help, Treatment as Usual (TAU)
- Where
- 5 sites in Spain
- Volunteers
- 342 people
- Sponsor
- Fundació Sant Joan de Déu