Clinical trials: Recurrent Implantation Failure
Low Molecular Weight Heparin, Recurrent Implantation Failure
Effect of Low Molecular Weight Heparin in Freeze-thaw Embryo Transfer Cycles in Women With Recurrent Implantation Failure
Recurrent implantation failure (RIF) is considered a tough problem in assisted reproductive technology (ART) without effective treatments. The effect of low molecular weight heparin (LMWH) in pregnancy outcomes is controversial.
- Conditions
- Low Molecular Weight Heparin, Recurrent Implantation Failure, FET, IVF
- Trial name
- NCT06991530
- Testing
- Low Molecular Weight Heparine
- Where
- China
- Volunteers
- 392 people
- Sponsor
- The Second Hospital of Shandong University
Infertility
Endometrial Local Injury and Implantation Failure
The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated.
- Trial name
- NCT00837733
- Testing
- Endometrial biopsy
- Where
- Iran
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Repeated Embryo Implantation Failure
Gcsf Injection in Women With Repeated Implantaiton Failure
The purpose of the study is to see the impact of intrauterine injection of recombinant GCSF on pregnancy and implantation rate during IVF-ICSI (intracytoplasmic sperm injection) protocols as well as in frozen embryo transfer.
- Trial name
- NCT02149277
- Testing
- Filgrastim
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Clinique Ovo
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility (IVF Patients), Acupuncture
Evaluation of Acupuncture's Effectiveness on Pregnancy Outcomes in Women with Recurrent Implantation Failure RIF: a Large Cohort Study
Title: Evaluating the Effectiveness of Acupuncture on Pregnancy Outcomes in Recurrent Implantation Failure (RIF) Patients Undergoing In Vitro Fertilization (IVF): A Large Cohort Study Objective: This study aims to assess the…
- Trial name
- AcupunctureRIF (NCT06708923)
- Testing
- Intervention Name: Acupuncture Therapy Before and After Embryo Transfer Description: The intervention involves acupuncture therapy performed at two key time points during the IVF cycle: 25 minutes be
- Where
- Vietnam
- Volunteers
- 1,969 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Recurrent Implantation Failure, Infertility (IVF Patients)
Endometrial Immune Profile in Recurrent Implantation Failure
The goal of this observational study is to learn whether differences in the immune cells of the womb lining (endometrium) help explain why some women do not become pregnant despite several IVF attempts using good-quality embryos…
- Trial name
- NCT07848399
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- King's College London
Infertility
Intralipid for Repeated Implantation Failure
Intralipid infusion can improve outcome in women with recurrent Intracytoplasmic sperm injection ( ICSI) failure due to elevated TH1 cytokine response.
- Trial name
- Intralipid (NCT01540591)
- Testing
- intralipid, Saline
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Miscarriage, Recurrent
Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group…
- Trial name
- NCT05437471
- Testing
- GNRH Analoge, Duphaston, Letrozole
- Where
- Malaysia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Recurrent Implantation Failure
Zishen Yutai Pill for Patients With Recurrent Implantation Failure
The goal of this clinical trial is to evaluate the efficacy of Zishen Yutai Pill (ZYP) on pregnancy outcomes following embryo transfer and its safety in patients with recurrent implantation failure.
- Trial name
- NCT07641088
- Testing
- Zishen Yutai Pill
- Where
- 13 sites in China
- Volunteers
- 878 people
- Sponsor
- Peking University Third Hospital
Implantation Failure
Oxytocin Antagonist in Patients With Repeated Failure of Implantation
In this study the investigators compare the usual way of embryo transfer (without medication) with an embryo transfer while administering oxytocine antagonist. This to improve implantation and increase the pregnancy rate.
- Trial name
- NCT01673399
- Testing
- Atosiban
- Where
- Belgium
- Volunteers
- 138 people
- Sponsor
- AZ Jan Palfijn Gent
Recurrent Implantation Failure, In Vitro Fertilization
Azathioprine in Recurrent Implantation Failure
Azathioprine increase pregnancy rate in patients with recurrent implantation failure
- Conditions
- Recurrent Implantation Failure, In Vitro Fertilization, Intracytoplsmic Sperm Injection
- Trial name
- NCT03498703
- Testing
- Azathioprine Pill
- Where
- 2 sites in Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recurrent Implantation Failure
PRP in Recurrent Implantation Failure
The endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy.
- Trial name
- NCT04085783
- Testing
- PRP
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dr. Kamal Rageh
Infertility
Use of Granulocyte Colony-stimulating Factor for the Treatment of Recurrent Implantation Failure in IVF Patients
The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of recurrent implantation failure in IVF patient with cause unknown or due to thin endometrium.
- Trial name
- NCT01315470
- Testing
- neupogen administration for women with recurrent IVF failure
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Female Infertility
NAC Effect on Hox Genes Expressions in RIF
Comparison of the group treated with NAC-supplementation and placebo- administered groups showed elevations in HOXA cluster genes (all members) expression level in endometrium of women with RIF.
- Trial name
- NCT03862586
- Testing
- N-acetyl cysteine
- Volunteers
- 40 people
- Sponsor
- Royan Institute
Subfertility
Assessment of Intralipid Efficacy in Women With Unexplained Recurrent Implantation Failure
The study will include 100 women with unexplained recurrent implantation failure undergoing IVF/ICSI cycle. Patients fulfilling the inclusion criteria will be randomised into two groups.
- Trial name
- NCT02487940
- Testing
- Intralipid 20%, Normal saline
- Volunteers
- 100 people
- Sponsor
- Dar El Teb Institute
Asherman Syndrome, Atrophic Endometrium
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
This study will assess the use of autologous bone marrow stem cells mobilization using 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane (PLERIXAFOR) as an effective medical therapy for the treatment of…
- Conditions
- Asherman Syndrome, Atrophic Endometrium, Recurrent Implantation Failure
- Trial name
- NCT05343572
- Testing
- Plerixafor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hugh Taylor
RIF , Endometrial Receptivity
Endometrial Receptivity in Patients With Recurrent Implantation Failure as a Preparatory Step for PET
clinical trial to improve pregnancy outcome in patient with RLF , study done on 2 phases. phase 1 to study variations of endometrial receptivity genes in this group of patient, phase 2 repeat cycle or transfer frozen embryo in…
- Trial name
- NCT03361839
- Testing
- endometrial biopsy
- Volunteers
- 60 people
- Sponsor
- Cairo University
Infertility
Intrauterine G-CSF Administration in RIF
Aim of this study is to investigate the effects of intrauterine G-CSF on endometrial thickness, clinical pregnancy rate and live birth rate in a recurrent implantation failure (RIF) group
- Trial name
- G-CSF (NCT03783208)
- Testing
- G-CSF, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Gurgan Clinic
Endometrial Receptivity, Repeated Implantation Failure
The Clinical Efficiency of Tb-ERA in Chinese RIF Patients
In order to further explore the clinical utility of endometrial receptivity array in patients with repeated implantation failure, the patients divide into the experimental group or the control group.
- Trial name
- NCT04497558
- Testing
- Endometrium biopsy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Recurrent Implantation Faliure, Infertility
Subendometrial Injection Versus Intrauterine Infusion of Platelet Rich Plasma for Women With Recurrent Implantation Failure
Aim of this study is to compare the effectiveness of subendometrial PRP injection \& intrauterine PRP infusion in women with recurrent implantation failure in comparison with a control group .
- Trial name
- NCT07306871
- Testing
- Platelet rich plasma, No intervention /standard care
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University