Clinical trials: Red Blood Cell
Drepanocytosis
Study of a Deformability Parameter of Red Blood Cell
Sickle-cell disease is one of the most common severe monogenic disorders in the world, it results in the synthesis of abnormal hemoglobin (HbS) instead of hemoglobin A.
- Trial name
- FITRED (NCT05850156)
- Testing
- basal blood collection, blood collection M6, blood collection M12
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Renal Failure, Chronic Kidney Disease
Extension Study to Evaluate Safety and Tolerability of Peginesatide for Long-Term Treatment of Anemia in Participants With CKD (EU)
The purpose of this study was to evaluate the long term safety and tolerability of peginesatide for the maintenance of hemoglobin in participants with chronic kidney disease (CKD) who had received at least 24 weeks of…
- Conditions
- Chronic Renal Failure, Chronic Kidney Disease, Anemia
- Trial name
- NCT00453973
- Testing
- peginesatide
- Where
- 20 sites in Bulgaria, Poland and 2 more
- Volunteers
- 114 people
- Sponsor
- Affymax
Red Blood Cell Disorder
The Protection of ACD III on Erythrocytes in Intraoperative Blood Salvage During Cardiopulmonary Bypass
To evaluate the effects of blood preservation solution III (sodium citrate, sodium dihydrogen phosphate, sodium citrate, glucose and adenine) in autologous blood recovery and storage bags on the metabolic morphological functions…
- Trial name
- NCT05267145
- Testing
- blood preservation solution III
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pain, Acute, Alloimmunisation in Pregnancy
Efficacy of Manuel Pressure and Local Cold Spray in Reducing Injection Pain in Pregnant Women
A randomized controlled study was planned to determine the effect of manual pressure and local cold spray application on the intensity of pain, fear, hemodynamic parameters, and satisfaction related to the pain reduction of human…
- Conditions
- Pain, Acute, Alloimmunisation in Pregnancy, Injection Site, Injection Fear
- Trial name
- NCT06231719
- Testing
- Cold Spray, Manuel Pressure, Standard Injection Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Gulsum Coskun
Cardiopulmonary Bypass, Cardiac Diseases
The Use of HEMOBAG to Salvage Blood After Cardiac Surgery
The avoidance of blood transfusions benefits the patient. Cardiopulmonary bypass (CPB) is routinely used in complex cardiac surgeries.
- Trial name
- NCT00176657
- Testing
- HEMOBAG Assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Blood Loss, Surgical
Evaluation of Thromboelastometry (ROTEM) During Spinal Surgery
The purpose of this study is to determine whether the use of ROTEM, during spinal surgery is effective on diminishing the total blood loss and the risk of Allogenic Transfusion of Blood Products vs control cases without ROTEM…
- Trial name
- ROTEM_SPINE (NCT02740374)
- Testing
- ROTEM, Standard of Care
- Volunteers
- 112 people
- Sponsor
- Ohio State University
Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD)
The Correlation Between Red Cell Transfusion and Complications of Prematurity
The aim of this clinical trial is to learn if there is a correlation between the erythrocyte transfusion in the early neonatal period in premature infants and early and late complications of prematurity.
- Conditions
- Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Enterocolitis, Necrotizing, Intraventricular Hemorrhage Neonatal
- Trial name
- NCT07123948
- Testing
- Wechsler Intelligence Test, performed by educated psychologists
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- Clinical Hospital Center Rijeka
Hematologic Malignancies, Inherited Disorders of Metabolism
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
- Conditions
- Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders
- Trial name
- NCT01351545
- Testing
- A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
- Where
- 142 sites in United States
- Volunteers
- 99,999 people
- Sponsor
- Center for International Blood and Marrow Transplant Research
Sickle Cell Disease
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions.
- Trial name
- NCT06944067
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Diamond Blackfan Anemia
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)
Gene therapy is a new possible treatment for the anemia of DBAS. Gene therapy will soon be available for patients with RPS19-mutated DBAS.
- Trial name
- NCT07186179
- Testing
- Mobilization Regimen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Packed Red Blood Cells
Interleukin-8 Level in Packed Red Blood Cells
1. To compare level of interleukin-8 between leukodepleted and non-leukodepleted packed red blood cells. 2. To show the effect of filtration of packed red blood cells on the level of inflammatory interleukin-8.
- Trial name
- NCT06530160
- Testing
- ELISA
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hereditary Spherocytosis, Hemolytic Anemia
New CBC Parameters in Diagnosis of Hereditary Spherocytosis
This cross-sectional study aims to evaluate the diagnostic performance of selected automated complete blood count-derived erythrocytic and reticulocytic parameters in children with hereditary spherocytosis.
- Trial name
- NCT07842718
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease
the Change of CEM and the Prognosis of Coronary Artery Disease in Real Clinical Practice
The purpose of this study is to investigate the change of total cholesterol content of erythrocyte membranes (CEM) in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the…
- Trial name
- CCEMPCAD (NCT03473860)
- Volunteers
- 200 people
- Sponsor
- Lu'an Municipal Hospital
Bone Marrow Failure Syndromes, Aplastic Anemias
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Dibotatug (DR-01) in Adults With Bone Marrow Failure Syndromes
This is a multicenter, open-label, Phase 1/2 basket study to evaluate the safety and efficacy of Dibotatug (DR-01) in adults with Bone Marrow Failure syndromes.
- Conditions
- Bone Marrow Failure Syndromes, Aplastic Anemias, Severe Aplastic Anemia (SAA), Severe Aplastic Anemia, Relapse
- Trial name
- BMF (NCT07712562)
- Testing
- Dibotatug (DR-01)
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Dren Bio
Malaria
Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria Vaccines
The ability to test candidate pre-erythrocytic stage malaria vaccines, using a well-established sporozoite challenge model, in a field setting with group sizes of tens rather than hundreds of volunteers would greatly facilitate…
- Trial name
- NCT00121823
- Testing
- FP9 ME-TRAP, MVA ME-TRAP
- Where
- The Gambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Thalassemia, Sickle Cell Disease
Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic blood and marrow transplantation remains the only viable cure for children who suffer from many serious non-malignant hematological diseases. Transplantation, however, carries a high risk of fatal complications.
- Conditions
- Thalassemia, Sickle Cell Disease, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
- Trial name
- NCT01319851
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Effect of Drug
The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes
Hypotension is frequently encountered during the use of these commonly used intravenous anaesthetic agents (thiopental and propofol).
- Trial name
- NCT06485388
- Testing
- Propofol, Thiopental
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Melike Cengiz
Thromboembolic Disease
The Correlation of Lewis Antigens With VTE
The goal of this observational study is to learn if certain factors in a person's blood are linked to a history of venous thromboembolic disease (VTED), which includes conditions like deep vein thrombosis.
- Trial name
- NCT07402005
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Sickle Cell Anemia
Study of Beet Juice for Patients With Sickle Cell Anemia
The investigators hypothesize that increasing plasma nitrite using dietary nitrate will improve platelet function and red cell deformability and decrease MCHC in patients with sickle cell disease.
- Trial name
- NCT02162225
- Testing
- beet juice (Unbeetable)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Red Blood Cell Disorder
Pathophysiological Explorations of Red Blood Cells
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of…
- Trial name
- GR-Ex (NCT03541525)
- Testing
- Biological sampling
- Where
- 25 sites in Benin, France and 1 more
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- Imagine Institute