Clinical trials: Red Blood Cell Transfusion
MDS, MDS/MPN
Study Investigating Patient-Reported Outcomes in Lower-risk MDS Patients
PRO-RED is a prospective, longitudinal, and multicenter observational study. Enrolled patients will be followed for 6 months in at least monthly intervals in terms of their received red blood cell transfusions and routine…
- Trial name
- PRO-RED (NCT05582902)
- Where
- 11 sites in Austria, Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Sickle Cell Disease
Age of Blood in Sickle Cell Transfusion
The Investigators hypothesize that older red cell units trigger phagocytosis and activation of circulating macrophages with a downstream immunomodulatory cascade and release of excess Non Transferrin Bound Iron(NTBI) that leads…
- Trial name
- NCT03704922
- Testing
- Transfusion
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of North Carolina, Chapel Hill
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Myocardial Infarction, Unstable Angina
Myocardial Ischemia and Transfusion Pilot
The purpose of this study is to evaluate two approaches to red blood cell transfusion in anemic patients with acute coronary syndrome.
- Conditions
- Myocardial Infarction, Unstable Angina, Coronary Artery Disease
- Trial name
- MINT Pilot (NCT01167582)
- Testing
- Red blood cell transfusion
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- Rutgers, The State University of New Jersey
Iron Overload Due to Repeated Red Blood Cell Transfusions, Thalassemia Majors (Beta-Thalassemia Major)
Evaluate the Efficacy and Safety of Irochel for the Management of Iron Overload in Thalassemia Patients in Comparison With Deferoxamine
This research study was an experimental, randomized, controlled clinical trial to evaluate the safety and efficacy of coded Unani formulation Irochel for the management of IOL due to repetitive blood transfusion in comparison…
- Trial name
- NCT07782931
- Testing
- Irochel, Deferoxamine
- Where
- Pakistan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Pulmonary Hypertension, Sickle Cell Disease
A Pilot Study of Chronic Red Blood Cell Transfusion in Sickle Cell Disease-Associated Pulmonary Hypertension
Pulmonary hypertension, a complication associated with an increased risk of death, is common in patients with sickle cell disease.
- Trial name
- NCT00850369
- Testing
- RBC transfusion
- Sponsor
- University of North Carolina, Chapel Hill
RBCs Transfusion in Critically-ill Patients
Red Blood Cell Transfusion to Optimize Extubation
In comparison with a liberal transfusion strategy (high haemoglobin threshold), a restrictive transfusion strategy leads to around 50% decrease in the total number of transfused red blood cells (RBC) units and 30% to 40% fewer…
- Trial name
- TEXT (NCT07499492)
- Testing
- Transfusion of a single unit of RBC and standard of care
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Iron Overload Due to Repeated Red Blood Cell Transfusions
Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184)
The purpose of this extension study is to evaluate SSP-004184AQ in patients with transfusional iron overload and to provide data on long term safety and efficacy.
- Trial name
- NCT01671111
- Testing
- SSP-004184AQ
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 30 people
- Sponsor
- Shire
Fibrin Blood Clot
Impact of Two Guided Transfusion Strategies on Blood Product Requirements in Liver Transplantation.
It is a national multicentre clinical study, where 3 hospitals are involved: Bellvitge University Hospital, Clinic Hospital of Barcelona and Cruces Hospital of Bilbao).
- Trial name
- NCT04405518
- Testing
- Fibrinogen Concentrate (Human) 1 MG [RiaSTAP]
- Where
- 3 sites in Spain
- Volunteers
- 188 people
- Sponsor
- Antoni Sabaté Pes
Anemia
Safety Study of ECO Conversion System For Red Blood Cells.
The purpose of this study is to demonstrate that small amounts of a person's own red cells, when treated with an enzyme to make A-ECO Red Blood Cells, can be safely re-infused, repeatedly.
- Trial name
- NCT00261274
- Testing
- A-ECO, Saline
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Velico Medical
Anemia
Iron Prophylaxis for Anemia in Infants With Cyanotic Congenital Heart Disease
Anemia is a common disorder in infants with one working chamber of the heart that pumps blood. Anemia is when the level of healthy blood cells becomes too low.
- Trial name
- NCT00459225
- Testing
- Iron (ferrous sulfate)
- Where
- United States
- Sponsor
- Emory University
Iron Overload Due to Repeated Red Blood Cell Transfusions
Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy
The purpose of this study is to evaluate SSP-004184AQ in patients with transfusional iron overload whose primary diagnosis is hereditary or congenital anemia.
- Trial name
- NCT01604941
- Testing
- SPD602
- Where
- 12 sites in United States, Canada and 3 more
- Volunteers
- 32 people
- Sponsor
- Shire
Transfusion Related Complication
S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion
The Purpose of the study is to test the hypothesis that administration of an S-nitrosylating (SNO) agent can improve tissue oxygenation during transfusion of packed red blood cells (RBCs).
- Trial name
- NCT03999229
- Testing
- SNO, Normal Saline, Red Blood Cell
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- James Reynolds
Critical Care, Anemia
Insufficient Cellular Oxygen in ICU Patients With Anaemia
The purpose of this study is whether the mitochondrial oxygenation tension (mitoPO2) is a feasible and reliable tool in ICU patients with anaemia undergoing red cell transfusion to ultimately personalize blood transfusion…
- Conditions
- Critical Care, Anemia, Erythrocyte Transfusion, Oxygen
- Trial name
- INOX ICU-2 (NCT03092297)
- Where
- 2 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Massive Transfusion, Bleeding During/Following Surgery
"ADE Fibrinogen/RBC" Ratio on Mortality and Outcome in Massive Transfusion Patients
Our study focuses on the transfusion of blood and blood products in cases of major bleeding, including massive transfusion scenarios where repeated doses of packed red blood cells (PRBC), fresh frozen plasma (FFP)…
- Trial name
- ADEFES (NCT06021184)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,679 people
- Sponsor
- Ankara City Hospital Bilkent
Anemia
Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia
The Pilot Optimizing Transfusion Thresholds in Critically-ill Children with Anaemia (P-OpTTICCA) study is a pilot trial for a large pragmatic international parallel open-label non-inferiority randomised controlled trial.
- Trial name
- P-OpTTICCA (NCT03871244)
- Testing
- Less red blood cell transfusions, More red blood cell transfusion (standard transfusion strategy in PICU)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- St. Justine's Hospital
Transfusion-dependent Anemia
Knowledge and Attitude in Perioperative Erythrocyte Transfusion in Medical Personnel in Siriraj Hospital
This study is designed to explore the correlation between knowledge and attitude in perioperative erythrocyte transfusion in medical personnel.
- Trial name
- NCT04155021
- Where
- Thailand
- Volunteers
- 250 people
- Sponsor
- Siriraj Hospital
Red Blood Cell Transfusion
An Innovative Trial Assessing Donor Sex on Recipient Mortality
The iTADS trial will test an important blood donor characteristic - donor sex - to see whether male donor blood leads to a greater benefit for transfusion recipients compared to female donor blood.
- Trial name
- iTADS (NCT03344887)
- Testing
- RBC Transfusion from male donor, RBC Transfusion from female donor
- Where
- Canada
- Volunteers
- 8,850 people
- Sponsor
- Ottawa Hospital Research Institute
Anemia, Critical Illness
Effect of Packed Red Blood Cell Transfusion on Eicosanoid Profiles in Plasma of Intensive Care Patients
The main goal of this pilot study is to assess the time course of eicosanoid profiles in intensive care unit (ICU) patients requiring packed red blood cell (PRBC) transfusion.
- Conditions
- Anemia, Critical Illness, Lung Transplantation, Open Aortic Surgery
- Trial name
- EICOTRANS-p (NCT03782623)
- Testing
- Analysis of eicosanoid profile prior to and after PRBC transfusion
- Where
- Austria
- Volunteers
- 23 people
- Sponsor
- Medical University of Vienna
Septic Shock
Transfusion-requirements in Septic Shock Trial
Patients with blood poisoning - sepsis - often receive blood transfusions in the intensive care unit. The evidence that blood transfusion leads to improved outcome is limited and the blood may be harmful to some of these…
- Trial name
- TRISS (NCT01485315)
- Testing
- SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion
- Where
- 32 sites in Denmark, Finland and 2 more
- Volunteers
- 1,005 people
- Sponsor
- Scandinavian Critical Care Trials Group