Clinical trials: Reduced Ejection Fraction
Heart Failure, Heart Failure With Reduced Ejection Fraction
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Obesity, Overweight
- Trial name
- SLEnDR (NCT05942287)
- Testing
- Diet intervention
- Where
- 2 sites in Jersey, United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction
Lokelma for RAAS Maximisation in CKD & Heart Failure.
Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of…
- Conditions
- Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction, Hyperkalemia, ACE Inhibitor Induced Hyperkalaemia
- Trial name
- LIFT (NCT05004363)
- Testing
- Lokelma Oral Product
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- St George's, University of London
Ventricular Ejection Fraction
DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function
The purpose of this clinical research study is to demonstrate the ability of Definity® enhanced versus unenhanced cardiac ultrasound to improve the accuracy and reproducibility of left ventricular ejection fraction (EF) when…
- Trial name
- NCT00401687
- Testing
- Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension
- Where
- 10 sites in United States
- Volunteers
- 131 people
- Sponsor
- Lantheus Medical Imaging
Heart Failure With Reduced Ejection Fraction
Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction
Research hypothesis: Fast telemonitored medical sequencing in patients with heart failure with reduced ejection fraction (HFrEF) is safe and feasible.
- Trial name
- TELE-FASTER (NCT05637853)
- Testing
- GDMT
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Heart Failure, Heart Failure and Reduced Ejection Fraction
Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure.
The purpose of this study is to compare the effects of three different modalities of inspiratory muscle training (IMT) in patients diagnosed with chronic heart failure who exhibit reduced or mid-range left ventricular ejection…
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction, Muscle Weakness
- Trial name
- IMT-HF-COMPARE (NCT07688863)
- Testing
- Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad Nacional Andres Bello
Diabetes Mellitus Type 2, Heart Failure
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with…
- Conditions
- Diabetes Mellitus Type 2, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT06774014
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
Validation of Two Wrist-worn Devices for the Assessment of Energy Expenditure in Cardiac Patients.
Improving physical activity is a core component of secondary prevention and cardiac (tele)rehabilitation. Commercially available activity trackers are frequently used to monitor and promote physical activity in cardiac patients.
- Trial name
- NCT03951740
- Testing
- Fitbit Charge 2, Mio Slice, Oxycon Mobile
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- Maxima Medical Center
Type 2 Diabetes Mellitus (T2DM), Chronic Heart Failure (CHF)
Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.
Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.
- Trial name
- GLID-HF (NCT07288749)
- Testing
- Glimepiride (oral)
- Where
- China
- Volunteers
- 1,484 people
- Sponsor
- Tongji Hospital
Heart Failure With Reduced Ejection Fraction
Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF
The goal of this clinical trial is to test a new type of pacemaker in heart failure patients following a heart bypass operation.
- Trial name
- RSA-PACE (NCT06359938)
- Testing
- Atrial pacing with respiratory sinus arrhythmia (RSA) variability, Monotonic right atrial overdrive pacing
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ceryx Medical Ltd
Heart Failure With Reduced Ejection Fraction
RECOVER-HF Pilot Study of SDS in Heart Failure
The RECOVER HF pilot is a feasibility study for evaluating a randomized, doubled-blinded study design to determine the benefits and risks of chronically delivering Synchronized Diaphragmatic Stimulation (SDS) in Heart Failure…
- Trial name
- NCT05592392
- Testing
- Synchronized Diaphragmatic Stimulation
- Where
- 2 sites in Georgia, Uzbekistan
- Volunteers
- 35 people
- Sponsor
- VisCardia Inc.
Chronic Heart Failure With Reduced Ejection Fraction, Worsening Heart Failure
A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction)
Researchers are looking for a better way to treat people who have chronic heart failure with reduced ejection fraction (HFrEF). HFrEF is a long-term condition where the left side of the heart does not pump blood out to the body…
- Trial name
- NCT05658458
- Testing
- Vericiguat (Verquvo, BAY1021189)
- Where
- 12 sites in India
- Volunteers
- 205 people
- Sponsor
- Bayer
Heart Failure
REALIsM-HF Pilot Study
The study aims to explore two marketed devices providing a multimarker monitoring including physical activity under real-life conditions in patients with heart failure with preserved ejection fraction (HFpEF) and with heart…
- Trial name
- REALIsM-HF (NCT03507439)
- Testing
- AVIVO Mobile Patient Management (MPM) System, VitalPatch biosensor, DynaPort Move Monitor
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 27 people
- Sponsor
- Bayer
Heart Failure With Reduced Ejection Fraction, Left Ventricular Assist Device
Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD
This is an exploratory project with the purpose to describe the responses of the right ventricle (RV) and gas exchange during exercise in patients scheduled to undergo left ventricular assist device (LVAD) implant.
- Trial name
- NCT05916612
- Sponsor
- Henry Ford Health System
Hyperkalaemia, Heart Failure With Reduced Ejection Fraction
Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone
The main objective of this study is to evaluate the efficacy of SZC as compared with placebo in keeping potassium levels within the normal range (3.5-5.0 mEq/L) while on spironolactone ≥25 mg daily without assistance of rescue…
- Trial name
- REALIZE-K (NCT04676646)
- Testing
- Sodium zirconium cyclosilicate, Spironolactone
- Where
- 89 sites in United States, Brazil and 6 more
- Volunteers
- 366 people
- Sponsor
- AstraZeneca
Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome
Developing Oral LT3 Therapy for Heart Failure - HFrEF
Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with reduced ejection fraction (HFrEF) and low triiodothyronine (T3) syndrome…
- Trial name
- DOT3HF-HFrEF (NCT04112316)
- Testing
- Liothyronine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania
Heart Failure, Pulmonary Hypertension
Cardiopulmonary Interactions in Patients With Heart Failure
This study aims to evaluate cardiopulmonary interactions in patients with heat failure
- Conditions
- Heart Failure, Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- NCT03317314
- Testing
- Lung Biopsy during LVAD Implantation
- Where
- Germany
- Sponsor
- Hannover Medical School
Heart Failure With Reduced Ejection Fraction, Acute Heart Failure
Optimize Heart Failure Care During TRANSitional Period in Patients With Acute Heart Failure.
The period of about a month after the discharge of acute heart failure patients is defined as a transition time. During this period, the patient has a high mortality rate and a readmission rate because the patient is not…
- Trial name
- TRANS-HF (NCT04900584)
- Testing
- Checklist, Education, Telephone monitoring
- Where
- South Korea
- Volunteers
- 1,009 people
- Sponsor
- Wonju Severance Christian Hospital
Sacubitril/Valsartan, Prosthetic Heart Valve
Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction
This study aims to evaluate the effect of sacubitril/valsartan in patients with prosthetic heart valves with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Sacubitril/Valsartan, Prosthetic Heart Valve, Heart Failure, Reduced Ejection Fraction
- Trial name
- NCT07192341
- Testing
- Sacubitril/Valsartan, Conventional anti-heart failure therapy
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Kafrelsheikh University
Tricuspid Insufficiency, Tricuspid Regurgitation (TR)
PASCAL Precision-GDMT Registry
The goal of this observational study is to demonstrate that successful tricuspid valve repair with the PASCAL Precision System in participants with at least severe tricuspid insufficiency and left ventricular dysfunction will be…
- Conditions
- Tricuspid Insufficiency, Tricuspid Regurgitation (TR), Left Ventricular Cardiac Dysfunction, Left Ventricular (LV) Systolic Dysfunction
- Trial name
- PASCAL (NCT07578129)
- Volunteers
- 50 people
- Sponsor
- Ceric Sàrl
Heart Failure
Qishen Yiqi Dripping Pills in Treatment of Chronic Heart FailUre
This trial will evaluate the efficacy and safety of Qishen Yiqi Dripping Pills in treatment of Chronic Heart Failure with reduced ejection fraction resorted from Coronary Heart Disease (Syndrome of Qi Deficiency with Blood…
- Trial name
- NCT07687186
- Testing
- Qishen Yiqi Dripping Pills 2 bags
- Where
- 60 sites in China
- Volunteers
- 636 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd