Clinical trials: Reduction in Pain
Neuroblastoma
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients
The purpose of this study is to identify whether or not the addition of a numbing medicine that is injected directly into the site of the bone marrow procedure can reduce pain and the use of opioid pain medication after bone…
- Trial name
- NCT02924324
- Testing
- propofol, ropivacaine, Wong-Baker FACES® Pain Rating Scale
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain
Reducing Post-Op Pain After Sacrospinous Ligament Colpopexy
This is a randomized controlled trial to determine if intraoperative local analgesia administered at the level of the sacrospinous ligament can lessen the gluteal pain felt by patients postoperatively after SSL colpopexy.
- Trial name
- NCT02037061
- Testing
- Bupivacaine, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Cleveland Clinic
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Preoperative Gabapentin for Post-tonsillectomy Pain in Children
The typical post-operative course for children following surgical removal of their tonsils and adenoids can be challenging, especially for pain control.
- Trial name
- NCT01707420
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Injection Site Irritation
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
This study is a randomized, single-site clinical trial that will take place at Children's Healthcare of Atlanta at Egleston. The investigators want to see if in pediatric patients, giving Zofran prior to propofol, reduces the…
- Trial name
- NCT05378113
- Testing
- Ondansetron, Lidocaine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Pain, Fever
Safety and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients
The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of intravenous ibuprofen administered over approximately ten (10) minutes.
- Trial name
- NCT02583399
- Testing
- Ibuprofen
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cumberland Pharmaceuticals
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Pain, Needle Phobia
The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
This study compares the efficacy of the Synera patch with Eutectic Mixture of Local Anesthetics (EMLA) as a topical anesthetic for venipuncture in pediatric patients.
- Trial name
- NCT00530803
- Testing
- EMLA Cream, Synera Patch
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Myofascial Trigger Point Pain (MTrP)
Percutaneous Microelectrolysis on Myofascial Trigger Points Pain.
The aim of the design is to investigate the value of percutaneous microelectrolysis (MEP) as an analgesic technique in myofascial trigger points.
- Trial name
- MEP (NCT03636386)
- Testing
- Percutaneous microelectrolysis, Ultrasound therapy
- Where
- Chile
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Quiropraxia y Equilibrio
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Opioid Use Disorder
Transcranial Magnetic Stimulation (rTMS) as a Tool to Decrease Pain and Improve Functioning
Despite the availability of opioid replacement therapies, many opioid use disordered Veterans are not able to remain abstinent. Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique with…
- Trial name
- TMS (NCT03821337)
- Testing
- repetitive Trans Magnetic Stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Malignant Neoplasm, Metastatic Malignant Neoplasm in the Bone
Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis
This randomized phase II trial studies how well palliative radiation therapy works in reducing pain in patients with cancer that has spread from the original (primary) tumor to the bone (bone metastasis).
- Conditions
- Malignant Neoplasm, Metastatic Malignant Neoplasm in the Bone, Pain
- Trial name
- NCT02699697
- Testing
- External Beam Radiation Therapy, Palliative Radiation Therapy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Wake Forest University Health Sciences
Ventral Hernias
Abdominal Binder to Reduce Pain and Seroma Formation
Postoperative seroma formation is one of the most common complications after ventral hernia repair. Although some seromas may not have clinical impact, postoperative seroma formation often causes pain and discomfort and may even…
- Trial name
- ABD- BINDER (NCT01673568)
- Testing
- ETO garments
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Hvidovre University Hospital
Pain of Anesthesia at Breast Biopsy
Reducing Pain of Lidocaine Injection
The purpose of this study is to determine the benefit, if any, of buffering lidocaine (adding sodium bicarbonate) when used for local anesthesia prior to percutaneous breast needle core biopsies.
- Trial name
- NCT02288364
- Testing
- 1% Lidocaine, 1% Lidocaine plus sodium bicarbonate
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Duke University
Cardiovascular Diseases
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin
AMR101 (icosapent ethyl [ethyl-EPA]) is a highly purified ethyl ester of eicosapentaenoic acid (EPA) developed by Amarin Pharma Inc.
- Trial name
- REDUCE-IT (NCT01492361)
- Testing
- AMR101, Statin therapy
- Where
- 410 sites in United States, Australia and 9 more
- Volunteers
- 8,179 people
- Sponsor
- Amarin Pharma Inc.
Geriatric, Chronic Pain
Positive Affect as a Source of Resilience for Adults in Chronic Pain
Fibromyalgia syndrome (FMS) is a chronic musculoskeletal condition characterized by widespread pain and tenderness, and often accompanied by impaired physical functioning, depressed mood, as well as deficits in positive affect…
- Trial name
- LARKSPUR (NCT04869345)
- Testing
- LARKSPUR
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pain
Reducing Operative and Post-operative Morbidity in Living Kidney Donors With the Airseal System
The purpose of this study is to determine if the Airseal System will reduce post-operative pain and reduce the need for narcotics in laparoscopic living kidney donor surgeries.
- Trial name
- NCT02262039
- Testing
- Valveless recirculating insufflation (VTI), Conventional pressure
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Yale University
Low Back Pain
SMART Clinical Study: Surgical Multi-center Assessment of RF Ablation for the Treatment of Vertebrogenic Back Pain
To evaluate the safety and efficacy of RF ablation using the Intracept Intraosseous Nerve Ablation System to ablate intraosseous nerves for the relief of chronic axial low back pain.
- Trial name
- SMART (NCT01446419)
- Testing
- Intracept Treatment
- Where
- 13 sites in United States
- Volunteers
- 225 people
- Sponsor
- Relievant Medsystems, Inc.
Analgesics, Gabapentin
Pregabalin vs. Gabapentin on Reducing Opioid Usage
This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease…
- Conditions
- Analgesics, Gabapentin, Injuries, Narcotics
- Trial name
- NCT04705480
- Testing
- Pregabalin 50mg, Gabapentin 300mg, Neither Pregabalin nor Gabapentin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- CAMC Health System