Clinical trials: Reflux
Barrett Esophagus, Gastroesophageal Reflux
Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
The purpose of this research study is to assess how safe, effective (how well it works), and tolerable (to put up with) the drug Zegerid is in reducing reflux episodes in patients who have both gastroesophageal reflux disease…
- Trial name
- NCT01129778
- Testing
- Zegerid (proton pump inhibitor), Bravo pH monitoring
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
GERD
A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects
A Study to compare Pharmacokinetics, Pharmacodynamics and safety of CKD-381 and D027 in healty subjects
- Trial name
- NCT03211143
- Testing
- CKD-381, Nexium
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux
An Assessment of pH Testing Methods
Gastroesophageal reflux disease (GERD) is a common and potentially debilitating disorder. Typical symptoms include heartburn and regurgitation of acid tasting substances.
- Trial name
- NCT01364610
- Testing
- Bravo, Standard Care
- Where
- 2 sites in Canada
- Volunteers
- 86 people
- Sponsor
- University of Calgary
Esophageal Diseases
Comparative Assessment of Esophagitis in Cases With and Without Esophageal Motility Disorders: A Prospective Study
Achalasia is a neuro-degenerative disorder marked by changes in the peristalsis of the esophagus and the lack of relaxation in the lower esophageal sphincter (LES), thought to be due to damage to the myenteric plexus with an…
- Trial name
- NCT06835374
- Testing
- Per oral endoscopy myotomy (Per oral endoscopy myotomy), Endoscopy procedure
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastric Reflux
Impact of Gastric Length of Myotomy During POEM on Gastroesophageal Reflux
This observational study will be conducted among 43 patients of both sexes in each group Study participants will be of the age more than 18 years STUDY PROCEDURE-Pre-defined technique to avoid bias and confounding due to multiple…
- Trial name
- IGL (NCT05500196)
- Testing
- Per Oral Endoscopy Myotomy (POEM)
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Asian Institute of Gastroenterology, India
GERD Gastroesophageal Reflux Disease, Laryngopharyngeal Reflux Disease
"The Voice of Reflux" - Backflow of Gastric Juice Leads to Irritation of the Vocal Folds: Are There Typical Differences in the Voice?
If gastric juice refluxes back into the oesophagus and up into the throat/pharynx/mouth area, causing discomfort or injury, this is known as reflux disease (reflux).
- Trial name
- NCT06495606
- Testing
- Voice sample; Recording with microphone + Questionnaire
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Laryngopharyngeal Reflux Symptoms, Laryngopharyngitis Chronic
Kazakh Version of Reflux Symptom Index
Reflux symptoms index (RSI) were developed to identify a clinical index of suspicion for laryngopharyngeal reflux (LPR) in patients with ear, nose, and throat symptoms.
- Conditions
- Laryngopharyngeal Reflux Symptoms, Laryngopharyngitis Chronic, Gastro Esophageal Reflux Disease
- Trial name
- NCT05296655
- Testing
- Reflux Symptom Index Inventory (diagnostic survey), Reflux finding score
- Where
- 2 sites in Kazakhstan
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Kazakh Medical University of Continuing Education
Morbid Obesity, Gastroesophageal Reflux Disease
Effect of RING on Gastroesophageal Reflux (GERD) After RYGBP
Silastic rings have been used around the gastric pouch in order to promote better weight loss after Roux-and-Y gastric bypass surgery ( RYGBP).
- Conditions
- Morbid Obesity, Gastroesophageal Reflux Disease, Vomiting
- Trial name
- RING (NCT01212835)
- Testing
- RYGBP-RING
- Where
- 3 sites in Brazil
- Volunteers
- 114 people
- Sponsor
- Clinica Gastrobese
Obesity, Bariatric Surgery Candidate
Multi-Strategy Intervention for Anesthesia Care of Obese Patients A Factorial Randomized Controlled Trial
The main objective of this study is to investigate the optimal anesthesia for obese patients undergoing bariatric surgery in the strategies of positive pulmonary ventilation, tracheal intubation technique, hemodynamic monitoring…
- Conditions
- Obesity, Bariatric Surgery Candidate, Tracheal Intubation Morbidity, Nausea and Vomiting, Postoperative
- Trial name
- NCT05016076
- Testing
- Dexamethasone 8 mg, Applied inspiratory pressure (10, 15, 20, or 25 cmH2O), Tracheal intubation using video intubating stylet, video laryngoscopy, or direct laryngoscopy
- Where
- Taiwan
- Sponsor
- YingHsuanTai
Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)
Saint Luc Valve Registry
The "Cliniques Universitaires Saint Luc" are one of the high specialized center in valvular heart diseases and valvular heart surgery.
- Trial name
- SaLVaRe (NCT02974218)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Heartburn, Gastro-esophageal Reflux
Assessment of Gastro-esophageal Reflux Using Endo-Flip vs Bravo
Monitoring oesophageal pH provides a definitive diagnosis of patients with gastro-oesophageal reflux disease (GORD), especially those in whom the association between reflux and symptoms is uncertain and those under consideration…
- Trial name
- NCT00481949
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Gastroesophageal Reflux Disease, Tooth Wear
Relationship Between Gastroesophageal Reflux Disease and Dental Erosion
This study aimed to investigate the relationship between gastroesophageal reflux disease (GERD) and dental erosion and the alterations in oral tissues. This was a case-control study.
- Trial name
- NCT04595500
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Beykent
GERD
A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Obesity has become a significant health problem in Canada. It is known to be a risk factor for many diseases, including Gastro-Esophageal Reflux Disease (GERD).
- Trial name
- GERD (NCT02142998)
- Testing
- 24 pH monitoring, Esophageal Manometry:
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Gastroesophageal Reflux, Esophageal Reflux
Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures
The purpose of this study is to compare the effects (good and bad) of the Laparoscopic Hill anti-reflux procedure with the Laparoscopic Nissen anti-reflux surgical procedure to see whether one is better than the other.
- Conditions
- Gastroesophageal Reflux, Esophageal Reflux, Gastroesophageal Reflux Disease, GERD
- Trial name
- NCT01260935
- Testing
- Laparoscopic Hill Repair, Laparoscopic Nissen Repair
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Swedish Medical Center
GERD
Asociación Española de Gastroenterologia (Spanish Gastroenterology Association) Gastroesophageal Reflux Disease Guideline - Prospective Study
To evaluate symptomatic outcome and HRQoL in GERD patients treated following a new CP Guideline.
- Trial name
- Prospect (NCT00697008)
- Where
- 29 sites in Spain
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Gastro-oesophageal Reflux
A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg.
- Trial name
- NCT00464308
- Testing
- Esomeprazole, Rabeprazole
- Where
- 25 sites in Australia
- Volunteers
- 1,392 people
- Sponsor
- Janssen-Cilag Pty Ltd
Gastroesophageal Reflux Disease, Chronic Insomnia
Effect of Rozerem on the Perception of GERD Symptoms in Patients With Chronic Insomnia.
To determine if administration of Rozerem in comparison to a placebo reduces or eliminates gastroesophageal reflux disease(GERD) symptoms in individuals with both GERD and chronic insomnia.
- Trial name
- Rozerem (NCT01128582)
- Testing
- Rozerem (ramelteon)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Southern Arizona VA Health Care System