Clinical trials: Reflux Disease
Vesico-Ureteral Reflux
Radiation-Free Technique for Evaluating Renal Scarring (RAFTERS)
In this research study the investigators want to study a safe, radiation-free technique known as contrast-enhanced ultrasound that may improve the ability to diagnose or evaluate renal scarring compared to regular ultrasound.
- Trial name
- NCT03653702
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Bile Reflux Gastritis, Gastric Cancer
Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia
- Trial name
- NCT03976739
- Where
- China
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Mitral Valve (MV) Regurgitation
HighLife Clarity Treatment of Severe Mitral Regurgitation
The purpose of the study is to evaluate the safety and effectiveness of the HighLife transcatheter trans-septal mitral valve replacement (TSMVR) system in NYHA Class ≥ II-IV patients with moderate-to-severe or severe mitral…
- Trial name
- HIGHFIVE (NCT06683729)
- Testing
- Trans-septal (TS) Mitral Valve Replacement (TSMVR) Valve system
- Volunteers
- 240 people
- Sponsor
- HighLife SAS
Obesity, Morbid, GERD
Sleeve Gastrectomy With Cruroplasty and Omental Rape for Treatment of Morbid Obesity With Reflux Disease
in this study the investigators will test anew technique to mange patients with morbid obesity and GERD by doing sleeve gastrectomy plus cruroplasty and omental rape around the gastroesophageal junction
- Trial name
- NCT05590208
- Testing
- sleeve gastrectomy+ cruroplasty+ omental rap
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Functional Gastrointestinal Disorders, Overlap Syndromes
Overlap FGIDs and Genetic Polymorphism
1. To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. 2.
- Trial name
- NCT04712617
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Gastro Esophageal Reflux Disease, Dyspepsia
Spirulina Platensis for PPI Withdrawal
Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound…
- Conditions
- Gastro Esophageal Reflux Disease, Dyspepsia, Rebound Acid Hypersecretion
- Trial name
- SpAReDPPI (NCT04988347)
- Testing
- Spirulina platensis
- Volunteers
- 45 people
- Sponsor
- Universidade de Passo Fundo
Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
EPX-HTG for Structural Heart Procedures
To investigate and evaluate the benefits of adding EchoPixel Holographic Therapy Guidance to the current standard of care in Structural Heart (SH) procedures.
- Trial name
- EPX-HTG-2026 (NCT07705425)
- Testing
- Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- EchoPixel, Inc.
Esophageal Motility Disorders, Gastro-esophageal Reflux
Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
Pressure and flow (PF) analysis allow a detailed report on the bolus passing for each segment of the esophagus. This approach has evidence in oropharyngeal dysphagia, post reflux surgery dysphagia, gastroesophageal reflux in…
- Trial name
- pFlow (NCT03904004)
- Testing
- Peroral endoscopic myotomy, Neumatic dilatation, Botulinum toxin injection
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Miguel Servet
Venous Leg Ulcer
Early Venous Reflux Ablation Ulcer Trial
The EVRA study evaluates the effects of early endovenous ablation on ulcer healing in patients with chronic venous ulceration. Half the patients are randomised to receive early endovenous ablation (within 2 weeks) and half to…
- Trial name
- EVRA (NCT03286140)
- Testing
- Early endovenous ablation, Delayed endovenous intervention
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Imperial College London
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (DE) (NCT07757776)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
Cough
Bronchial Hyper-responsiveness in Reflux Cough
The study aim is to determine the effect of 8 weeks of anti-reflux treatment (full acid suppression) on bronchial hyper-responsiveness and whether there is a symptomatic improvement.
- Trial name
- NCT00668317
- Testing
- Omeprazole, Ranitidine
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Gastroesophageal Reflux Disease
Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Manometry in Patients With GERD
The aim of this study is to establish and validate High resolution manometry (HRM) criteria for the definition of transient lower esophageal sphincter relaxations (tLESRs) in gastroesophageal reflux disease (GERD) patients.
- Trial name
- HRM RTSIO (NCT01844440)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Bordeaux
Heartburn, Gastroesophageal Reflux Disease
Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients
The purpose of this study is to determine the efficacy and safety of dexlansoprazole compared to placebo in relief of daytime and nighttime heartburn over 4 weeks in Chinese participants with symptomatic non-erosive…
- Trial name
- NCT02873689
- Testing
- Dexlansoprazole
- Where
- 25 sites in China
- Volunteers
- 217 people
- Sponsor
- Takeda
GERD
Endoscopic Band Ligation for Treating Reflux Disease
GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve.
- Trial name
- NCT06126055
- Testing
- Band Ligation
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- El Katib Hospital
GERD, Hiatal Hernia
Long-term Follow-up After Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing
10 years of follow-up after surgery for hiatal hernia by tension-free mesh closure or simple suturing.
- Conditions
- GERD, Hiatal Hernia, Dysphagia, Esophageal, Quality of Life
- Trial name
- NCT05069493
- Testing
- simple suturing, mesh
- Where
- Sweden
- Volunteers
- 103 people
- Sponsor
- Karolinska University Hospital
GERD, Reflux Esophagitis
A Novel Endoloop Pre-test to Treat Gastroesophageal Reflux
The purpose of this study was to evaluate the safety and efficacy of endoscopic endoloop pre-test for gastroesophageal reflux before anti-reflux surgery or endoscopic treatment.
- Trial name
- NCT05192538
- Testing
- Endoscopic endoloop pre-test treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
GERD, Gastro Esophageal Reflux
Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features
Gastroesophageal reflux disease is a commonly encountered disorder in daily practice. Proton pump inhibitor therapy has been the cornerstone of treatment for decades.
- Trial name
- NCT04028466
- Testing
- Vonoprazan, Omeprazole
- Where
- Philippines
- Volunteers
- 82 people
- Sponsor
- St. Luke's Medical Center, Philippines
Gastroesophageal Reflux Disease, Reflux, Gastroesophageal
Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg.
Current treatment for gastroesophageal reflux disease(GERD)confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric acid suppression.
- Trial name
- NCT00551473
- Testing
- Lavoltidine
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Barrett Esophagus Adenocarcinoma
Impact of an Endoscopic Treatment of the Line Z on the Gastronomic Recurrence and the Gastro- Esophageal Reflux Disease in the Care of the Adenocarcinoma of Barrett's Oesophagus
Barrett's oesophagus is a transformation of the esophageal mucous membrane there intestinal metaplasia under the effect of gastro- esophageal reflux disease (GERD).
- Trial name
- B-ARMS (NCT03278327)
- Testing
- Complete endoscopic resection at Day 1 and months 2, 4, 6 8 and month 10., Endoscopic resection at month 2 and month 4
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Paoli-Calmettes
Gastroesophageal Reflux
Serial Exhaled Breath pH Monitoring
This study will seek to determine the amount of acids a person with a chronic cough that is suspected to be related to acid reflux breathes out after coughing.
- Trial name
- NCT00330603
- Testing
- Serial exhaled breath collections
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Virginia