Clinical trials: Refractory Constipation, open to volunteers
Refractory Constipation, Somatic Symptom Disorder (DSM-5)
Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features
This single-center, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of fluoxetine (40 mg/day) versus placebo in 194 adults with refractory chronic constipation exhibiting Somatic Symptom…
- Conditions
- Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)
- Trial name
- REFLECT (NCT06506136)
- Testing
- Fluoxetine
- Volunteers
- 194 people
- Sponsor
- Zhifeng Zhao, PhD
Refractory Constipation
Optimization of taVNS Intervention Strategies for Refractory Constipation
The goal of this clinical trial is to learn whether transcutaneous auricular vagus nerve stimulation (taVNS) works to treat refractory constipation in adults. It will also learn about the safety and tolerability of taVNS.
- Trial name
- NCT07344402
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Functional Constipation (FC), Somatic Symptom Disorder (DSM-5)
Transcranial Alternating Current Stimulation for Refractory Constipation With Somatic Symptom Disorder
The purpose of this randomized, double-blind, placebo-controlled trial is to evaluate the efficacy and safety of transcranial alternating current stimulation (tACS) in adults with refractory functional constipation comorbid with…
- Conditions
- Functional Constipation (FC), Somatic Symptom Disorder (DSM-5), Refractory Constipation
- Trial name
- RELIEF-tACS (NCT07323407)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Refractory Constipation, Fecal Incontinence in Children
The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation
This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans…
- Trial name
- NCT07291661
- Testing
- High resolution anorectal manometry using a multiuse water perfused catheter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Constipation, Refractory
Long-term Evaluation of Percutaneous Endoscopic Caecostomy in Refractory Constipation
This observational monocentric study aims to evaluate the long-term effectiveness and tolerance of percutaneous endoscopic caecostomy (PEC) in patients with chronic refractory constipation.
- Trial name
- CONSTICAP 2 (NCT07160192)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Constipation - Functional, Refractory Constipation
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients.
- Conditions
- Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI
- Trial name
- NCT06221722
- Testing
- BOLD-fMRI, Regular treatment of functional constipation, fluoxetine
- Where
- 3 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases