Clinical trials: Refractory Epilepsy in Children, active
Refractory Epilepsy in Children
Non-Helium Magnetoencephalography in Pediatric Refractory Epilepsy
The goal of this observational study is to evaluate the effectiveness of Magnetoencephalography (MEG) in the preoperative assessment of children with refractory epilepsy, particularly in identifying the seizure focus, and to…
- Trial name
- NCT07064421
- Testing
- Magnetoencephalography plus Stereo-electroencephalography/Electrocorticography, Stereo-electroencephalography/Electrocorticography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Drug Resistant Epilepsy
CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children
Epilepsy is a neurological disorder affecting more than 50 million people globally, including more than 260,000 Canadians. Cannabidiol (CBD) reduces seizure frequency and improves quality of life for adults and children with Drug…
- Trial name
- CAN-DRE (NCT07023744)
- Testing
- CBD Isolate, CBD CHE
- Volunteers
- 90 people
- Sponsor
- University of Manitoba
Neuroblastoma
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma
The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory neuroblastoma.
- Trial name
- NCT04106219
- Testing
- LY3295668 Erbumine, Topotecan, Cyclophosphamide
- Where
- 17 sites in United States, Australia and 7 more
- Volunteers
- 71 people
- Sponsor
- Eli Lilly and Company
Epilepsy Intractable
A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy Children
The goal of this observational study is to compare the prevalence and severity of eating behaviors-such as food neophobia, picky eating, food fussiness, meal repetition and variety, and food texture preferences-between healthy…
- Trial name
- NCT07714226
- Where
- 2 sites in Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Pediatric Epileptic Syndrome, Partial-onset Seizures
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic…
- Trial name
- NCT04015141
- Testing
- Perampanel Oral Suspension, Perampanel Tablet
- Where
- 35 sites in United States, Belgium and 4 more
- Volunteers
- 100 people
- Sponsor
- Eisai Inc.
Drug Resistant Epilepsy, Autism Spectrum Disorder
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD.
- Conditions
- Drug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, Pediatric
- Trial name
- NCT06309251
- Testing
- ketogenic diet (as per clinical practice)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Danone Nutricia SpA Società Benefit
Refractory Epilepsy in Children, Refractory Epilepsy
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials
The goal of this clinical trial is to learn if cannabidiol ("CBD-oil") works to treat severe epilepsy in children. It will also learn about the safety of cannabidiol.
- Conditions
- Refractory Epilepsy in Children, Refractory Epilepsy, Epilepsy
- Trial name
- CBD-uN1que (NCT07668856)
- Testing
- Cannabidiol (CBD) oral solution
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Developmental and Epileptic Encephalopathy, Epilepsy in Children
Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
This study focuses on children with Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy that often has a genetic origin.
- Trial name
- EEPILOG (NCT07396883)
- Testing
- Long-read Whole Genome Sequencing (lrWGS)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Perinatal Stroke, Epilepsy
Long-Term Epilepsy Outcomes in Children With a History of Perinatal Stroke
Perinatal stroke is a rare condition affecting approximately 20-40 births per 100,000. It may be ischemic or hemorrhagic and can occur before or around birth, with diagnosis sometimes delayed until motor or cognitive symptoms…
- Conditions
- Perinatal Stroke, Epilepsy, Post-Stroke Epilepsy
- Trial name
- EPI-STROKE (NCT07898397)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsies, Focal, Pediatrics
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities.
- Conditions
- Epilepsies, Focal, Pediatrics, Drug Resistant Epilepsy
- Trial name
- EPITRACT (NCT03268824)
- Testing
- Electroencephalogram (EEG), Diffusion Tensor imaging, Language assessment
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy (Treatment Refractory), Epilepsy in Children
OPM MEG in Pre-surgical Mapping for Patients With Epilepsy
Magnetoencephalography, or "MEG", is a brain-scanning method which has been available for many years. It is used in the UK and worldwide to help patients with epilepsy, who need surgery to resolve their seizures.
- Conditions
- Epilepsy (Treatment Refractory), Epilepsy in Children, Epilepsy in Youth
- Trial name
- NCT07378397
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Aston University
Epilepsy; Seizure
Deep Brain Stimulation vs. Vagus Nerve Stimulation for Epileptic Spasms
Deep Brain Stimulation vs. Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Control Trial
- Trial name
- DBS-VNS-ES (NCT07010276)
- Testing
- DBS Arm, VNS arm
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Drug Resistant Epilepsy, Epilepsy
MRgFUS for Childhood Epilepsy
The goal of this observational study is to learn if magnetic resonance imaging guided focused ultrasound (MRgFUS) can treat brain lesions causing epilepsy in children with drug resistant epilepsy.
- Trial name
- NCT07497178
- Testing
- Ablation
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Transcranial Electric Stimulation, tDCS
Optimized and Personalized Trans-cranial Brain Stimulation in Partial Refractory Epilepsies
Epilepsy is one of the most common neurological diseases, affecting between 0.5% and 1% of the general population. Therefore, new diagnostic and treatment methods are having a big impact on society.
- Conditions
- Transcranial Electric Stimulation, tDCS, Epilepsy, Pharmacoresistant
- Trial name
- PerEpi2 (NCT06212609)
- Testing
- transcranial electrical stimulation therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Epilepsy, Rare Diseases
Cannabidiol in Children and Young Adults With Rare Disease-associated Severe Epilepsy
This is a pilot, open-label, phase II study. The main objective of the study is to demonstrate that Cannabidiol (CBD), used in addition to current anti-seizure medications (ASMs) reduces the number and/or severity of motor…
- Trial name
- CBD_RE (NCT05803434)
- Testing
- Cannabidiol oral solution
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Meyer Children's Hospital IRCCS