Clinical trials: Refractory Pain, open to volunteers
Lower Back Pain
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
This clinical study is being conducted to evaluate the safety, tolerability, plasma pharmacokinetics and efficacy of an investigational drug called CNTX-3001.
- Trial name
- NCT07122453
- Testing
- CNTX-3001
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Trigeminal Neuralgia, Refractory Pain
Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia
A prospective exploratory study aiming at comparing pulsed bipolar versus pulsed unipolar radiofrequency ablation in patients with medically refractory trigeminal neuralgia.
- Trial name
- NCT06779578
- Testing
- Bipolar pulsed radiofrequency, Mopolar pulsed radiofrequency
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic
Refractory Diabetic Foot Neuropathic Pain
Short-term SCS for Refractory Diabetic Foot Neuropathic Pain
This single-center, assessor-blinded randomized controlled trial enrolls 88 patients with drug-refractory diabetic foot neuropathic pain unsuitable for revascularization surgery.
- Trial name
- NCT07740707
- Testing
- Standardized Routine Diabetic Foot Therapy, Standard Routine Therapy + 14-day Short-term Spinal Cord Stimulation
- Volunteers
- 88 people
- Sponsor
- Nanchong Central Hospital
Coccyx Disorder
Analgesic Efficacy of Capsaicin 8% Patch (QUTENZA®) in Coccygodygnia
A retrospective study over a period of 6 years to explore analgesic efficacy of 8% Capsaicin patch (QUTENZA®) in coccygodynic patients, as well as neuropathic predictive factors of therapeutic response.
- Trial name
- CAPSACOXp (NCT05983263)
- Testing
- Capsaicin
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Gastrointestinal Motility Disorder, Gastroparesis
IVIG for Drug and Device Refractory Gastrointestinal Auto-Immune Neuropathy
Patients with the symptoms of generalized GI dysmotility, including gastroparesis, are sometimes refractory to available medications, devices and other interventions/ Some of these patients have serologic and/or endo organ…
- Conditions
- Gastrointestinal Motility Disorder, Gastroparesis, Neuropathy
- Trial name
- GAIN (NCT04208828)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Louisville
Crohns Disease
Treatment of Moderate to Severe Refractory Crohn's Disease
This research study is testing an investigational research product called TRX103 as a possible treatment for individuals suffering from Crohn's Disease (CD).
- Trial name
- NCT06721962
- Testing
- TRX103, Cyclophosphamide
- Where
- 13 sites in United States
- Volunteers
- 39 people
- Sponsor
- Tr1X, Inc.
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Limb Pain, Phantom
A Study of Contralateral Limb Block
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.
- Trial name
- NCT06045936
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Erector Spinae Plane Block
Nerve Block for Severe Abdominal Pain in the Emergency Department
Currently, the standard treatment of nonsurgical abdominal pain in the Emergency Department (ED) includes narcotic pain medication. This can be addictive and contributes to the current opioid epidemic.
- Trial name
- ESPB (NCT07826936)
- Testing
- Bupivacaine (erector spinae plane block)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Irvine
Malignant Bowel Obstruction, Cancer Pain
Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction
Malignant bowel obstruction is a frequent complication of advanced cancer, particularly of abdominal and pelvic origin, and most affected patients experience pain.
- Conditions
- Malignant Bowel Obstruction, Cancer Pain, Intestinal Obstruction
- Trial name
- NCT07856251
- Testing
- Lidocaine
- Volunteers
- 50 people
- Sponsor
- Fundación Santa Fe de Bogota
Neuropathic Pain, Chronic Pain
Insula Neuromodulation for Chronic Neuropathic Pain
This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.
- Trial name
- NCT05404581
- Testing
- neuromodulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Refractory Cancer Pain, Cancer Pain
Hydromorphone With Electroacupuncture and Ear Acupoint Pressing for Refractory Cancer Pain
This trial aims to address refractory cancer pain (RCP). It will explore the synergistic efficacy and safety of hydromorphone hydrochloride sustained-release tablets (HHST) combined with electroacupuncture (EA) and ear acupoint…
- Trial name
- NCT07489625
- Testing
- Hydromorphone Hydrochloride Extended-Release Tablets, Electroacupuncture, Ear Acupoint Pressing Beans
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qinghai Red Cross Hospital
Neuropathic Chronic Pain
Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if the topical anesthetic cream works to treat neuropathic chronic pain in older adults who have not found sufficient relief undergoing other pain treatments and/or medications.
- Trial name
- NCT07396129
- Testing
- Lidocaine (23%) + Tetracaine (7%)
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Chronic Pain, Intractable Pain
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU).
- Conditions
- Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain
- Trial name
- MOSAIC (NCT07190807)
- Testing
- Boston Scientific WaveWriter Alpha™ SCS Systems
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation
Pain, Cervical, Discogenic Pain
Evaluation of Efficacy and Safety of Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain
The purpose of this study is to assesse safety and efficacy of the Intradiscal Gelified Ethanol for treatment in refractory cervical discogenic pain.
- Trial name
- DISCOCERV (NCT05969392)
- Testing
- Intradiscal Gelified Ethanol (Discogel)
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Gelscom SAS
Adhesive Capsulitis of the Shoulder, Frozen Shoulder
Transcatheter Arterial Embolization Using Nexsphere-F for Chronic Shoulder Pain Refractory to Conservative Treatment
Evaluation of the efficacy and safety of transcatheter arterial embolization using 'Nexsphere-F' for pain relief in patients with adhesive capsulitis of the shoulder joint that does not respond to conservative treatment.
- Conditions
- Adhesive Capsulitis of the Shoulder, Frozen Shoulder, Shoulder Adhesive Capsulitis
- Trial name
- TAE-FROST (NCT07336849)
- Testing
- Transcatheter Arterial Micro- Embolization (TAME), Usual care (conservative management)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Chung-Ang University Hospital
Refractory Pain
OP2C : Prialt® Observatory in Clinical Practice
Ziconotide is a strong analgesic marketed since 2005 in Europe and reserved for the intrathecal route. Its efficacy has been proven in particular by 3 randomized clinical studies.
- Trial name
- OP2C (NCT04321408)
- Testing
- Ziconotide Injection
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Coronary Microvascular Disease, Refractory Angina
COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina
Patients with refractory microvascular angina fulfilling the predefined inclusion and exclusion criteria will be enrolled in this randomized trial.
- Trial name
- COSIMA (NCT04606459)
- Testing
- Coronary sinus reducer, Optimal medical therapy
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- Johannes Gutenberg University Mainz
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA