Clinical trials: Refractory Status Epilepticus
Generalized Convulsive Status Epilepticus, Intensive Care Unit
Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.
Study Hypothesis Generalized Convulsive Status Epilepticus (GCSE) is a medical emergency associated with an increased morbidity and a prolonged length of hospital stay.
- Trial name
- VALSE (NCT01791868)
- Testing
- Intravenous Sodium Valproate
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus, Convulsive Status Epilepticus
Predictors of Outcomes of Convulsive Status Epilepticus
Status epilepticus is a life-threatening neurological emergency characterized by prolonged seizures or multiple seizures occurring without the patient regaining consciousness between episodes.
- Trial name
- NCT07853391
- Volunteers
- 100 people
- Sponsor
- Assiut University
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Seizure
Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures
Convulsive prolonged seizures in children are the most common life-threatening neurological emergencies. The aim of active management of seizure control is to prevent irreversible neuronal damage as early as possible.
- Trial name
- NCT07098728
- Testing
- Levetiracetam IV, Phenobarbital
- Where
- 2 sites in Burma
- Volunteers
- 180 people
- Sponsor
- Ministry of Health and Sports, Myanmar
Grand Mal Status Epilepticus
Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus
This study is a randomized, open label, parallel group,comparing the safety and efficacy of valproate and levetiracetam in patients of age group 1 to 16 years with status epilepticus not responded to phenytoin and benzodiazepines…
- Trial name
- NCT02920060
- Testing
- Intravenous levetiracetam, Sodium valproate
- Volunteers
- 80 people
- Sponsor
- Banaras Hindu University
Grand Mal Status Epilepticus, Non-convulsive Status Epilepticus
Refractory Status Epilepticus Treatment Study
Identify the most effective dose of valproic acid when used in combination with phenytoin for treatment of patients with refractory status epilepticus, which allow a better clinical course and prognosis of the disease.
- Trial name
- NCT01586208
- Testing
- valproic acid (VPA)
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Universitari de Bellvitge
Refractory Status Epilepticus
To Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ganaxolone Added to Standard of Care in Refractory Status Epilepticus (RSE)
This is a multicenter, double-blind, randomized, placebo-controlled study that will evaluate the efficacy, safety, and tolerability of intravenous (IV) ganaxolone versus placebo co-administered with IV antiepileptic drug (AED)…
- Trial name
- NCT05814523
- Testing
- Ganaxolone, Standard of care
- Where
- 52 sites in Austria, Belgium and 14 more
- Sponsor
- Marinus Pharmaceuticals
Super-Refractory Status Epilepticus
A Study With SAGE-547 for Super-Refractory Status Epilepticus
This is a randomized, double-blind, placebo-controlled trial, designed to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to subjects in Super-Refractory Status Epilepticus (SRSE).
- Trial name
- NCT02477618
- Testing
- SAGE-547
- Where
- 171 sites in United States, Austria and 14 more
- Volunteers
- 132 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Status Epilepticus
Exogenous Ketone Esters for Refractory Status Epileptics
This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus
- Trial name
- EKERSE (NCT05674552)
- Testing
- Exogenous ketone ester
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Epilepsy, Status Epilepticus
Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus
The purpose of the study is to evaluate the efficacy and safety of levetiracetam , lacosamide and ketamine treatment of refractory status epilepticus.
- Trial name
- NCT02726867
- Testing
- levetiracetam, lacosamide, Ketamine
- Where
- United States
- Sponsor
- Mid-Atlantic Epilepsy and Sleep Center, LLC
Convulsive Refractory Status Epilepticus, Status Epilepticus
Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus
The HYBERNATUS-II study is a phase-III, open-label, randomized controlled trial in patients with convulsive refractory SE receiving mechanical ventilation.
- Trial name
- HYBERNATUS II (NCT07383779)
- Testing
- Targeted Hypothermia
- Where
- 20 sites in France
- Volunteers
- 466 people
- Sponsor
- Versailles Hospital
Status Epilepticus, Cardiac Arrest
Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest
Status epilepticus (SE) is found in 20-30% of patients in coma after cardiac arrest, is often refractory to medical therapy and is considered a negative prognostic factor.
- Trial name
- SUPER-CAT (NCT05756621)
- Testing
- Ketamine, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel
- Where
- 10 sites in Italy
- Volunteers
- 84 people
- Sponsor
- University of Milano Bicocca
Refractory Status Epilepticus
Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus
Isoflurane might be used as anticonvulsive therapy in refractory status epilepticus. The aim of the study is to assess the efficiency of Isoflurane in this indication.
- Trial name
- I-Seizure (NCT05830864)
- Testing
- Isoflurane
- Where
- 4 sites in France
- Volunteers
- 66 people
- Sponsor
- Hopital of Melun
Status Epilepticus, Refractory Status Epilepticus
Feasibility Study: tDCS for Treatment of Refractory Status Epilepticus
Status epilepticus, or recurrent seizures without return to baseline, is a neurologic emergency. Refractory status epilepticus occurs when seizures are resistant to multiple first line anti-seizure medications.
- Trial name
- NCT05934903
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Status Epilepticus
EEG Monitoring for Refractory Status Epilepticus
This is a prospective randomized study to investigate the yield of continuous electroencephalogram (cEEG), as a diagnostic tool in intensive care unit (ICU), for patients with refractory status epilepticus (RSE) and the…
- Trial name
- NCT04170491
- Testing
- Continuous EEG
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust