Clinical trials: Regenerative Endodontics
Symptomatic Irreversible Pulpitis
Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis
Root canal therapy (RCT) is a classical and effective treatment that is currently utilised in dental practice, offering high success rates for pulp and periapical diseases; however, teeth after RCT are susceptible to altered pulp…
- Trial name
- NCT06525844
- Testing
- regenerative endodontic therapy using I-PRF, blood clot
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids
This clinical study will be conducted to evaluate the effect of using intracanal Omega-3 Fatty acids during revascularization of necrotic immature teeth compared to the traditional induced bleeding technique.
- Trial name
- Regeneration (NCT07371416)
- Testing
- Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Regenerative Endodontic Treatment, Cleaning and Shaping Only With Proper Coronal Seal
Outcomes of Conventional Root Canal Treatment Compared to Regenerative Endodontics, and Cleaning and Shaping Only in Mature Upper First Premolars
It was to compare clinically between the success of the primary endodontic treatment, regeneration, and only cleaning and shaping in necrotic mature first premolars with apical periodontitis
- Conditions
- Regenerative Endodontic Treatment, Cleaning and Shaping Only With Proper Coronal Seal, Necrotic Mature First Premolar
- Trial name
- NCT07609732
- Testing
- cell homing, Cleaning and shaping only
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apexification, Apexogenesis
Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Children often damage their front teeth. In approximately 6% of cases, the nerve inside the affected tooth dies (becomes 'non-vital') and natural root development stops.
- Conditions
- Apexification, Apexogenesis, Pulp Necrosis, MTA
- Trial name
- NCT01817413
- Testing
- Mineral trioxide aggregate, Revascularisation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Necrotic Pulp, Apical Periodontitis
Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis
The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation…
- Trial name
- NCT04018456
- Testing
- Biodentine, White MTA
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Chronic Apical Periodontitis
Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth
The goal of this clinical trial is to learn whether regenerative endodontic treatment (RET) should be performed in one visit or two visits in people with mature permanent teeth with chronic apical periodontitis.
- Trial name
- NCT07480226
- Testing
- Single-Visit Regenerative Endodontic Treatment, Multiple-Visit Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Marmara University
Dental Pulp Regeneration
Comparison of Tissue in Regenerative Endodontic Procedures and Apexification
The purpose of our study is to characterize the composition of the hard and soft tissues present after regenerative endodontic procedures in root canals of teeth previously diagnosed with the need for extraction for orthodontic…
- Trial name
- NCT01805388
- Testing
- Experimental: Regeneration Treatment Group, Control Non-Study Drug Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kenneth Hargreaves
Apical Periodontitis
The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study
The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic…
- Trial name
- NCT06764004
- Testing
- Stem Cell Product, Bleeding and clots
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Apical Periodontitis
Bone Regenerative Techniques in Endodontic Microsurgery
The purpose of this randomized controlled clinical trial was to evaluate two dimensionally and 3-dimensionally the effect of resorbable collagen-based bone filling material on periapical healing following endodontic microsurgery…
- Trial name
- NCT04514991
- Testing
- Foundation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Periapical Periodontitis, Tooth Diseases
Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
This study evaluates the clinical effect of regenerative endodontic procedure using PRF in immature permanent teeth with apical periodontitis.
- Conditions
- Periapical Periodontitis, Tooth Diseases, Stomatognathic Diseases
- Trial name
- NCT02801552
- Testing
- PRF
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Infected Immature Permanent Teeth
Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children
This study evaluates the efficacy of Antibiotic pastes or Calcium hydroxide disinfection on healing of periapical pathology and continued root development of infected non-vital immature permanent teeth in children.
- Trial name
- NCT03327844
- Testing
- RET using antibiotics (Ciprofloxacin and Metronidazole), RET using non-setting Calcium Hydroxide
- Where
- 2 sites in Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
Endodontic Disease, Regenerative Endodontics
Evaluation of Different Scaffolds in Regenerative Endodontic Treatment
The aim of this study is to evaluate and compare the regenerative potentials of Injectable Platelet-Rich Fibrin (I-PRF), Platelet-Rich Fibrin (PRF), and Blood Clot (BC) as different scaffolds regarding: Radiographic outcomes…
- Trial name
- NCT06945965
- Testing
- Injectable platelet-rich fibrin (i-PRF) scaffold, platelet-rich fibrin (PRF)scaffold, blood clot (BC) scaffold
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Regenerative Endodontics
Clinical and Radiographic Outcomes of PRF, Chitosan, and Blood Clot in Regenerative Endodontics of Molars
This clinical trial aimed to evaluate the long-term effects of using chitosan, blood clots, and platelet-rich fibrin as scaffolds in regenerative endodontics on tooth development.
- Trial name
- NCT07119619
- Testing
- Regenerative Endodontic Treatment Using a Blood Clot as a Scaffold, Regenerative Endodontic Treatment Using a Chitosan as a Scaffold, Regenerative Endodontic Treatment Using a Platelet Rich Fibrin as a Scaffold
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Inonu University
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necroses
Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth
The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.
- Trial name
- NCT04390854
- Testing
- Blood clot scaffold, Blood clot scaffold combined with PRF
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nourhan M.Aly
Regenerative Endodontic Procedures, Irreversible Pulpitis
Endodontic Success of Coronally Sealed Non-obturated Canals, Regeneration-based Canals
Statement of problem: Limitations and drawbacks associated with root canal obturation have the potential to impair periapical healing especially in the absence or delay of a proper coronal seal.
- Trial name
- NCT07679152
- Testing
- Regenerative Endodontics procedures, Cleaning and Shaping Only and coronal seal, Conventional root canal treatment
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ain Shams University
Necrotic Pulp, Regenerative Endodontic Procedures
Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial
This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Mature Teeth, Apical Periodontitis
- Trial name
- NCT06886438
- Testing
- RVS, L-PRF, i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Randomized Clinical Trial
Clinical and Radiographic Outcome of Regeneration in Immature Permanent Human Teeth Using a New Scaffold
This study aimed to evaluate clinical and radiographic outcome of regeneration in immature permanent human teeth using two different types of scaffolds: 1. Collagen-hydroxyapatite scaffold (Osteon III collagen) after blood clot.
- Trial name
- NCT06812351
- Testing
- Osteon III collagen, Blood clot
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Regenerative Endodontics
Regenerative Endodontics in Mature Permanent Teeth
this study was designed to compare the clinical and radiographic success of REPs after using blood clot scaffold in non-vital mature permanent teeth with or without photobiomodultion therapy
- Trial name
- NCT05892536
- Testing
- dental regenerative endodontics
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Salma fathy