Clinical trials: Regional Blood Flow
Vascular Disease, Critical Lower Limb Ischemia
Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia
The purpose of this study is to evaluate the effects of Hemospan infusion on vascular reactivity, regional perfusion and oxygenation of ischemic tissue in patients with chronic critical lower limb ischemia.
- Trial name
- NCT00633659
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Sangart
Glaucoma
Effects of Common Topical Glaucoma Therapy on Optic Nerve Head Blood Flow Autoregulation During Increased Arterial Blood Pressure and Artificially Elevated Intraocular Pressure in Healthy Humans
Background Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve circulation has been shown in animals and…
- Trial name
- NCT00275756
- Testing
- Timolol (drug), dorzolamide (drug), brimonidine (drug)
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Multiple Sclerosis
Regional Cortical Cerebral Quantitative MRI Perfusion Correlation Neurocognition in Multiple Sclerosis
Multiple Sclerosis (MS) is a common disease affecting 1/1000 Canadians. Cognition impairment is reported in 40-65% of patients and is socially and functionally disabling.
- Trial name
- NCT00812474
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ocular Physiology, Regional Blood Flow
Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
Prostaglandins (PG) are known to alter regional ocular blood flow and exhibit vasoactive properties in isolated ocular blood vessels.
- Trial name
- NCT00275730
- Testing
- indometacine (drug) effect on ocular blood flow
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Aging
Role of Flavanols in Exercise and Aging
It has well known that diets rich in fruits, vegetables and cocoa products are associated with positive health benefits and these positive effects have been shown to be due to compounds they contain called flavanols.
- Trial name
- NCT01557738
- Testing
- High Flavanol Trial, Low Flavanol Trial, High Flavanol Trial; long-term
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Blood Flow
Regional Blood Flow During Peripheral Heating
Blood flow through the popliteal, brachial, and carotid arteries during peripheral heating of the feet
- Trial name
- NCT06192992
- Testing
- Peripheral heating of 2 feet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Vasodilation, Diabetes Mellitus, Type 2
Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics
Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics.
- Trial name
- VMD (NCT05492071)
- Testing
- Local Vibration Application Following Flow Mediated Dilation, Flow mediated dilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Macular Degeneration, Regional Blood Flow
The Effect of a Single Intravitreal Anti-VEGF Therapy on Optic Nerve Head Perfusion
Age related macula degeneration is one of the most common sight threatening diseases of the elderly. The so called wet form of AMD is caused by choroidal neovascularisation (CNV) of pathological vessels, which lead to leakage…
- Conditions
- Macular Degeneration, Regional Blood Flow, Vascular Endothelial Growth Factor
- Trial name
- NCT00709657
- Testing
- ranibizumab, bevacizumab or pegaptanib
- Where
- Austria
- Volunteers
- 8 people
- Sponsor
- Medical University of Vienna
Autoregulation
Regulation of Choroidal Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Trial name
- NCT00812526
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Prediabetic State
Physical Activity and Obesity
The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by…
- Conditions
- Obesity, Prediabetic State, Sedentary Lifestyle
- Trial name
- NCT02060240
- Testing
- High Activity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Type 1, Insulin
The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp
Impaired retinal blood flow has been implicated in the pathogenesis of diabetic retinopathy. Patel et al. (1992) showed that retinal blood flow increases with the level of diabetic retinopathy. Grunwald et al.
- Conditions
- Diabetes Mellitus, Type 1, Insulin, Retina, Regional Blood Flow
- Trial name
- NCT00814008
- Testing
- Insulin, Glucose
- Where
- Austria
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Regional Anesthesia, Interscalene Blocks
Comparative Impacts of Two Anesthesia Methods on Peripheral Tissue Oxygenation in the Upper Limb
This study will aim to compare the effects of two different anesthesia techniques-general anesthesia (GA) and interscalene brachial plexus block (ISB)-on forearm tissue oxygenation in patients undergoing shoulder surgery.
- Conditions
- Regional Anesthesia, Interscalene Blocks, Shoulder Surgery, Perfusion Index
- Trial name
- NCT07449611
- Testing
- General Aneasthesia, Interscalene block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sakarya University
Organ Preservation, Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion
Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures
The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death…
- Trial name
- NONOFLOW (NCT07423936)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Cerebral Blood Flow
Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)
This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP.
- Trial name
- NCT05775263
- Testing
- CT angiogram
- Volunteers
- 10 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Glaucoma, Open-Angle, Circadian Rhythm
Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes
After focusing many years only on intraocular pressure (IOP) as the primary risk factor, recently the impact of ocular blood flow is getting more consideration for the pathophysiology of glaucoma.
- Conditions
- Glaucoma, Open-Angle, Circadian Rhythm, Intraocular Pressure, Regional Blood Flow
- Trial name
- NCT00707226
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Antioxidants on Skin Blood Flow During Local Heating
The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasodilation
- Trial name
- NCT03680638
- Testing
- Control (Lactated Ringer's), Tempol, Apocynin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Regional Blood Flow, Optic Disk
Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans
Because of their antiinflamatory effects, glucocorticoids are often used to reduce edema in neurologic tissue and to otherwise mitigate the consequences of neural inflammation.
- Trial name
- NCT00312325
- Testing
- Prednisolone
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Vienna
Acute Ischemic Stroke, Large Vessel Occlusion
Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion
The goal of this observational study is to describe the local change in interleukin-6 (IL-6) across a blood clot in adults with acute ischemic stroke caused by anterior circulation large vessel occlusion who are undergoing…
- Trial name
- IMPACT-LVO (NCT07754942)
- Testing
- Prospective Mechanical Thrombectomy Cohort
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Hospital Xiamen University
Irritable Colon, Irritable Bowel Syndrome (IBS)
Study On The Effect Of GW876008 On Cerebral Blood Flow In Irritable Bowel Syndrome (IBS) Patients And Healthy Volunteers
This is a three-period crossover study to compare GW876008 and placebo to see if GW876008 will normalise blood flow responses after different emotional stimuli.
- Trial name
- NCT00376896
- Testing
- GW876008 200mcg, GW876008 20mcg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline