Clinical trials: Rejection
Healthy
Reject Analysis of Periapical Radiographs of Dental Implants.
Periapical radiographs of dental implants, acquired as part of two ongoing research projects, will be retrospectively analyzed using a newly developed image quality scoring form.
- Trial name
- RA1-2025 (NCT07876687)
- Where
- Belgium
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Ghent
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
A Trial of Two Daclizumab Dosing Strategies vs. No Induction Treatment With Tacrolimus, Mycophenolate Mofetil , & Steroids for the Prevention of Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
The purpose of the study is to determine the safety and efficacy of two dosing regimens of daclizumab in simultaneous kidney/pancreas transplant recipients.
- Trial name
- NCT00363116
- Testing
- Daclizumab
- Where
- 24 sites in United States, Canada
- Volunteers
- 298 people
- Sponsor
- University of Cincinnati
Acute Rejection of Liver Transplant, Effects of Immunosuppressant Therapy
SRL (Sirolimus) Withdrawal
The significance of this clinical trial lies in its potential to increase the success of immunosuppression (IS) therapy withdrawal in liver transplant (LT) recipients, thus decreasing the negative impact of IS on their long-term…
- Trial name
- SRL (NCT02062944)
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Northwestern University
Kidney Transplant
Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Concentrations and Outcomes in Thai Transplant Recipients
Tacrolimus is a drug used commonly in kidney transplant patients to prevent graft rejection. Tacrolimus acts in a very narrow range in the blood for its optimum activity.
- Trial name
- NCT02377791
- Testing
- SNP: CYP3A5 gene polymorphisms
- Volunteers
- 170 people
- Sponsor
- Mahidol University
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Kidney Transplant Infection, Kidney Transplant Rejection
Evaluation of Cell-mediated Immune Response by QuantiFERON Monitor® Assay in Kidney Transplant Recipients
All kidney transplant recipients require immunosuppression, the net level of which is difficult to assess. Current practice in assessing immune reactivity is to monitor levels of some immunosuppressive drugs.
- Trial name
- NCT03488771
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- Clinical Hospital Merkur
Bronchiolitis Obliterans
Immune Mechanisms of Rejection in Human Lung Allografts
The investigators have obtained compelling evidence that the development of anti-human leukocyte antigen (anti-HLA) antibodies against mismatched donor antigens significantly correlates with the development of bronchiolitis…
- Trial name
- NCT00861900
- Volunteers
- 778 people
- Sponsor
- Washington University School of Medicine
Prophylaxis of Organ Rejection
Bioequivalency Study of Mycophenolate Mofetil 250 mg Capsules Under Fed Conditions
The objective of this study was to prove the bioequivalence of Mycophenolate Mofetil 250 mg Capsules under fed conditions.
- Trial name
- NCT00893919
- Testing
- mycophenolate mofetil
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Autoimmune Diseases
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells
The purpose of this pilot trial is to determine whether a conversion from calcineurin inhibitors (CNI) and mycophenolate mofetil (MMF) to a regimen consisting of efalizumab and sirolimus is associated with an increase in T…
- Trial name
- NCT00777400
- Testing
- Efalizumab
- Where
- United States
- Sponsor
- University of California, San Francisco
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Immunity, Cellular
Clinical Evaluation of Quantiferon-Monitor to Predict Outcomes in Solid Organ Transplant Recipients
The study will prospectively determine the clinical utility of non-pathogen specific cellular immunity assessment using the Quantiferon-Monitor to quantify the degree of immunosuppression.
- Trial name
- QTF-Monitor (NCT02560857)
- Testing
- Quantiferon-Monitor assay
- Where
- Canada
- Volunteers
- 151 people
- Sponsor
- Deepali Kumar
Kidney Transplantation
Bortezomib With Steroid Pulse Therapy for Acute Cellular Rejection in Kidney Transplantation
The purpose of this study is to determine whether bortezomib is effective in the treatment of acute cellular rejection after kidney transplantation.
- Trial name
- NCT02351427
- Testing
- Bortezomib, Steroid
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Implant or Graft; Rejection
Implant Placement in Horizontally Deficient Maxillary Aesthetic Zone With Simultaneous Soft Tissue Augmentation
Tooth extraction in maxillary esthetic zone is accomplished with great dimensional changes of the alveolar ridge, different procedures have been tested to compensate these dimensional alteration, such as Hard bone augmentation…
- Trial name
- NCT05274256
- Testing
- implant placement with simultaneous soft tissue augmentation
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cairo University
Kidney Transplant Rejection, Kidney Transplant; Complications
Australian Genomics Of Chronic Allograft Dysfunction Study
The goal of the Australian Genomics of Chronic Allograft Dysfunction (AUSCAD) study is a single centre (Westmead Hospital), prospective, observational study, which enrols patients at time of kidney (or kidney-transplant)…
- Trial name
- AUSCAD (NCT06314230)
- Where
- 2 sites in Australia
- Volunteers
- 500 people
- Sponsor
- Western Sydney Local Health District
Kidney Transplant Failure and Rejection
Home Based Monitoring of Kidney Transplants Utilizing Capillary Microsamples
Renal transplant recipients are followed as out patients at the transplant center for about 8 weeks after surgery. Between 1-2 weeks after surgery, 50 standard immunological patients will be randomized (1:1) to either follow…
- Trial name
- HBM-KTx (NCT04369612)
- Testing
- Standard follow-up, Home-based monitoring
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Kidney Transplant Rejection
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03363945
- Testing
- MDR-101
- Where
- 19 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Medeor Therapeutics, Inc.
Kidney Transplant Failure and Rejection
A Follow up Study of Patients Treated With Imlifidase Prior to Kidney Transplantation
The rationale for the current protocol is to collect data from extended follow up in subjects that have received a kidney transplant following imlifidase dosing to provide a better understanding regarding the long-term outcome…
- Trial name
- NCT03611621
- Testing
- Imlifidase
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 31 people
- Sponsor
- Hansa Biopharma AB
Kidney Transplant Rejection
TruGraf and TRAC In Pediatrics Study
This is a pilot 3 center prospective study of pediatric renal kidney recipients undergoing protocol biopsies examining the performance of the TruGraf gene expression test in children and adolescents.
- Trial name
- TTIPS (NCT05335538)
- Testing
- Patients monitored with TruGraf and TRAC testing
- Where
- 3 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- Transplant Genomics, Inc.
Microvascular Inflammation
A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation
In this study, researchers will learn more about a drug called felzartamab in people who have received a kidney transplant and later developed a condition called microvascular inflammation (MVI).
- Trial name
- TRANSPIRE (NCT07219043)
- Testing
- Felzartamab
- Where
- 51 sites in United States, Argentina and 9 more
- Volunteers
- 81 people
- Sponsor
- Biogen
Prophylaxis of Organ Rejection
Bioequivalency Study of Mycophenolate Mofetil 250 mg Capsules Under Fasted Conditions
The objective of this study was to prove the bioequivalence of Mycophenolate Mofetil 250 mg Capsules under fasted conditions.
- Trial name
- NCT00893542
- Testing
- Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories