Clinical trials: Relatives
Diabetes Mellitus
A Study to Evaluate the Effect of Food on the Pharmacokinetics of Sotagliflozin and to Explore the Relative Bioavailability in Healthy Subjects
Primary Objective: To evaluate the effect of food on the single-dose pharmacokinetics of sotagliflozin relative to a fasted state in healthy adult male and female subjects.
- Trial name
- NCT03174548
- Testing
- Sotagliflozin (SAR439954)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sanofi
Locally Advanced Cervical Cancer, Prognostic Biomarker
Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors
Cervical cancer is strongly associated with HPV infection, yet current post-treatment follow-up relies on cytology and imaging, which have limited accuracy, particularly after radiotherapy.
- Trial name
- ANIHTA (NCT07600515)
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Cancer
Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation
The purpose of this open-label, randomized, 2-treatment, 2-period crossover study with incomplete washout is to evaluate the relative bioavailability of 2mg GSK1120212 pediatric oral solution formulation in comparison to 2mg…
- Trial name
- NCT01647659
- Testing
- Trametinib tablet, Trametinib pediatric formulation
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- GlaxoSmithKline
Gastric Cancer, Genetic Predisposition
Research for Associated Genes for Gastric Cancer in Family Member With Affected First-Degree Relatives
Familial gastric cancer accounts for 10% of all cases, but predisposing genetic variations is unknown except for CDH1 mutation. Because Germline mutation is believed to be a key aspect of cancer predisposition, we plan to recruit…
- Trial name
- NCT03486574
- Testing
- Positive result from pathological test
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
COVID-19, Cytokine Storm
Intercellular Adhesion Molecule-1 and TNF-α in Patients With COVID-19
This study aimed to assess the cytokine profile in COVID 19 patients and its relation with disease progression \& severity using COVID reporting and data system (CORADS) score.
- Trial name
- NCT05408325
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Hand Hygiene, Skin Irritation
Evaluation of Effectiveness and Mildness of Whole-natural Hand-wash Formulations
The purpose of this study is to evaluate the effectiveness of whole-natural hand-wash formulations in bacterial removal and to estimate the relative mildness of the formulations.
- Trial name
- NCT02645110
- Testing
- MC Hand Soap, Tap water
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mother's Choice Ltd
Gaucher Disease
Role of Vitamin E in Gaucher Disease Patients
gaucher disease (GD) can be classified into three clinical types .type 1,the most common type ,is the chronic non neuronpathic form of the disease,which shows gighly variable signs and symptoms and variable course,with…
- Trial name
- NCT06211478
- Testing
- Vitamin E
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Living-relative Kidney Transplantation
Induction With SVF Derived MSC in Living-related Kidney Transplantation
The objective of this trial is to determine if autologous SVF derived MSC can effectively reduce the need for post transplant immunosuppressant in living-relative kidney transplantation.
- Trial name
- NCT02492308
- Testing
- SVF-MSC induction, Basiliximab induction
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Fuzhou General Hospital
Imposter Syndrome, Medical Students
Imposter Syndrome in Medical Students and Its Relation With Stress
The goal of this observational study is to examine the relationship between Imposter Syndrome and stress in undergraduate medical students at Rawalpindi Medical University, with particular attention to variables such as gender…
- Trial name
- NCT07019974
- Where
- Pakistan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Healthy
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
Bioavailability and food effect of 2 formulations of PF-06650833 in healthy volunteers.
- Trial name
- NCT03308110
- Testing
- PF-06650833
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Ataxia Telangiectasia, Growth Failure
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT)
This study will evaluate the status of the growth hormone/ insulin-like growth factor-1 (GH/IGF-1) axis in relation to growth failure, body weight and composition and neuroprotection in children with Ataxia telangiectasia (AT).
- Trial name
- GHAT (NCT01052623)
- Testing
- Somatropin, Clonidine, L-Arginin-Hydrochloride, Estradiol valerate
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Healthy Volunteers
A Study to Evaluate the Relative Bioavailability of Povetacicept Formulations and Bioequivalence of Povetacicept Presentations
The purpose of this study is to evaluate the relative bioavailability of Povetacicept formulations, bioequivalence of Povetacicept presentations, and safety and tolerability of Povetacicept.
- Trial name
- NCT07010406
- Testing
- Povetacicept
- Where
- 2 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Hamstring Injuries
Prevention of Hamstring Injuries in Football Players.
Introduction: The prevalence of hamstring injuries in football is high, causing an increase in the number of casualties and a high socio-economic cost.
- Trial name
- NCT05773404
- Testing
- Passive Neurodynamics and Passive axial hip mobilisation/distraction, Active therapy, 2.5.3. Combined therapy
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Universidad Católica de Ávila
Liver Cirrhoses
Risk Factors of Liver Fibrosis Among First Degree Relatives of Patients With NASH Related Cirrhosis (NRC)
The study aim to identify the risk factors of liver fibrosis among first degree relatives. This study consists of 2 parts (Cross Sectional and Case Control Study).
- Trial name
- NCT04057287
- Testing
- No intervention
- Where
- India
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hiv
Relative Bioavailability Study to Investigate a Potential Interaction Between DTG DT and F/TAF TOS.
This relative bioavailability (RBA) study will be conducted to investigate whether there is a potential pharmacokinetic effect when paediatric DTG and F/TAF are taken together as dispersible formulations.
- Trial name
- UNIVERSALRBA (NCT05489406)
- Testing
- DTG DT (6 x 5 mg), F/TAF TOS (3 x 60/7.5 mg)
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy
A Study in Healthy Men to Compare Two Different Oral Formulations of BI 1810631 and to Test How Food or Rabeprazole Influence the Amount of BI 1810631 in the Blood
BI 1810631 trial formulation 1 (TF1) is currently used in clinical trials, but is planned to be replaced by another formulation (principle) in future clinical trials and on the market.
- Trial name
- NCT05380947
- Testing
- BI 1810631 - trial formulation 1 (TF1), BI 1810631 - new formulation (NF), Rabeprazole sodium
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cardiovascular Surgery, Bispectral Index
BIS Monitoring in Relation to Muscle Relaxant Administration
The purpose of this study is to determine the overall optimal timing of when the Bispectral Index (BIS) monitor should be started: before or after the muscle relaxant is given.
- Conditions
- Cardiovascular Surgery, Bispectral Index, Anesthesia
- Trial name
- NCT05440058
- Testing
- Bispectral Index (BIS) monitoring system
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Critical Illness, Muscle Wasting
Acute Skeletal Muscle Wasting and Relation to Physical Function in Patients Requiring ECMO
The purpose of this study is to describe the changes in quadriceps muscle size and quality over the first 10 days on extracorporeal membrane oxygenation (ECMO) using ultrasound imaging.
- Conditions
- Critical Illness, Muscle Wasting, Extracorporeal Membrane Oxygenation
- Trial name
- NCT03026985
- Testing
- Observational cohort
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- The Alfred
Healthy Volunteers
Bioavailability Study of Naloxone 5 Milligrams (mg) Intramuscular (IM) Autoinjector
To compare the plasma concentration (bioavailability) and safety of a single naloxone 5 mg autoinjector intramuscular (IM) injection to a single 2 mg IM injection (an approved safe dose) and to a single 2 mg bolus intravenous…
- Trial name
- NCT05264493
- Testing
- NaxRedy ™, Naloxone Hydrochloride Injection, USP
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 1 Diabetes
BABYDIET-Study - Primary Prevention of Type 1 Diabetes in Relatives at Increased Genetic Risk
The major goals of this project are to determine whether primary intervention through delayed introduction of dietary gluten is feasible and could reduce the incidence of islet autoimmunity in high-risk first degree relatives of…
- Trial name
- NCT01115621
- Testing
- Glutenfree diet during the first year of life
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Institut fur Diabetesforschung, Munich, Germany