Clinical trials: Relatives
Healthy
A Relative Bioavailability Study of Gabapentin Tablets 800 mg Under Fasting Conditions
The purpose of this study is to compare the relative bioavailability of 800 mg Gabapentin Tablets by Purepac Pharmaceutical Co. with that of 800 mg NEURONTIN® Tablets by Parke-Davis following a single oral dose (1 x 800 mg) in…
- Trial name
- NCT00865423
- Testing
- Gabapentin 800 mg Tablets, single dose, NEURONTIN® 800 mg Tablets, single dose
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Healthy
Muslce Oxygenation of the Quadricep Relative to Angle and Load
The purpose of the present study is to determine if the amount of oxygen in muscles during resistance exercise with different weights is related to changes in torque or knee joint angle.
- Trial name
- MORAL (NCT06638788)
- Testing
- Knee extension
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cancer Cachexia Syndrome
Lenalidomide for Lean Body Mass and Muscle Strength in Inflammatory Cancer Cachexia Syndrome
Cancer cachexia syndrome (CCS) is frequent, causing high morbidity and mortality in affected ones. The mechanism is catabolism caused by the tumour. CRP is a surrogate marker for catabolism.
- Trial name
- NCT01127386
- Testing
- Lenalidomide, basic cachexia management (prokinetics, physical activity counselling, nutritional counselling)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Florian Strasser, MD ABHPM
Pancreatic Cancer, Adult, Cachexia
Relation Between Cachexia, Diabetes and periNeural Invasion in PANcreatic Cancer- Biomarkers Substudy
The purpose of this study is to determine the interrelationship between cachexia, neural invasion and diabetes in patients with pancreatic cancer.
- Conditions
- Pancreatic Cancer, Adult, Cachexia, Pain, Diabetes Mellitus
- Trial name
- CDNPAN (NCT03042442)
- Testing
- Point-of care biomarkers, Clinical, venous blood samples, pancreatic tissue, Follow-up
- Where
- Romania
- Volunteers
- 114 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Clinical Trials, Phase I as Topic
First in Human Study to Investigate the Safety and Tolerability, Pharmacokinetics, Itraconazole Drug-drug-interaction and Food Effect of BAY1817080
This study is a first in human study that will investigate the safety, tolerability and pharmacokinetics of ascending single doses of BAY1817080 using a placebo controlled, randomized, single center design.
- Trial name
- NCT02817100
- Testing
- BAY1817080, Itraconazole
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bayer
Kidney Transplantation
An Open Study Assessing Bioavailability of a Modified Formulation of Tacrolimus in Kidney Transplant Recipients
The purpose of this study is to evaluate the effect of food on the oral bioavailability of tacrolimus modified release (MR4) capsules together with a standard continental breakfast.
- Trial name
- NCT00865137
- Testing
- Tacrolimus, modified release
- Where
- Netherlands
- Volunteers
- 27 people
- Sponsor
- Astellas Pharma Inc
Hypertension
To Demonstrate the Relative Bioavailability Study of Ramipril 10 mg Capsules Under Fasting Conditions
To demonstrate the relative bioavailability study of Ramipril 10 mg capsules under fasting conditions.
- Trial name
- NCT00946465
- Testing
- Ramipril 10 Capsule (Sandoz), Altace (Ramipril) 10 Capsule (Aventis Pharmaceutical)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sandoz
Healthy Participants
Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants
The purpose of this study is to assess the relative bioavailability of the high concentration liquid formulation (HCLF) of gantenerumab produced with the G4 process in comparison to the same HCLF of gantenerumab produced with the…
- Trial name
- NCT03236844
- Testing
- Gantenerumab
- Where
- 3 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Glucose Control
Genetic Variation in CLTCL1 and Whole-body Glucose Control
Maintaining stable blood glucose concentrations after eating has important implications for health. Individuals who are better able to maintain stable blood glucose concentrations after consuming carbohydrate have a lower risk of…
- Trial name
- NCT03998111
- Testing
- Oral glucose tolerance test
- Where
- United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Javier Gonzalez
Primary Haemostasis Disorder in Cardiac Surgery Patients
Relation Between the Value of Platelet Clot Stiffness (PCS) Obtained by Sonorheometric Method of Delocalized Hemostasis (QUANTRA®), and the Presence of a Disorder of Primary Hemostasis, in Cardiac Surgery Patients. PLAQUA-Study
The goal of this study is to determine whether the Platelet Clot Stiffness (PCS) measured by QUANTRA® is predictive of an abnormality in primary haemostasis intraoperatively in cardiac surgery performed under extracorporeal…
- Trial name
- PLAQUA (NCT06585930)
- Testing
- Blood sample
- Where
- Reunion
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
IBS - Irritable Bowel Syndrome
The Effect of Dietary Intervention on Symptoms, Epigenetics, and Gut Microbiota in IBS
The aim of the present study is to research whether subjects with irritable bowel syndrome (IBS) display epigenetic/genetic changes or altered microbiota compared to a non-IBS control group.
- Trial name
- NCT03306381
- Testing
- Dietary intervention
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Region Skane
Tooth Extraction, Tooth Extraction Site Healing
Comparison of Intraligamentary Anesthesia With the Inferior Alveolar Nerve Block for the Extraction of Mandibular Molars.
Local anaesthesia or numbing is done before tooth extraction. This study compares two different methods of numbing molar teeth before extraction.
- Trial name
- NCT06611865
- Testing
- Intraligamentary anaesthesia, Inferior alveolar nerve block
- Where
- Pakistan
- Volunteers
- 535 people
- Sponsor
- Hamza Zia Ahmed
Colorectal Cancer
Serum Endocan Levels in Colorectal Cancer
This case-control study aims to measure serum endocan levels in patients with colorectal cancer and healthy controls using ELISA and to compare the levels between the two groups.
- Trial name
- NCT07842692
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
Divalproex Sodium 500 mg Extended Release Tablets Under Non-Fasting Conditions
This study was designed to compare the relative bioavailability (rate and extent of absorption) of Divalproex Sodium ER Tablets 500 mg with that of Depakote® ER Tablets 500 mg following a single, oral dose (1 x 500 mg extended…
- Trial name
- NCT00974012
- Testing
- Divalproex Sodium, Depakote®
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Chronic Kidney Disease
Study to Assess Relative Bioavailability and Safety of AZD5718 in Healthy Volunteers
This study will be a randomised, open-label, 3-period, 3-treatment, single-dose, crossover study in healthy subjects The study will be performed at a single study centre in the United Kingdom.
- Trial name
- NCT04734275
- Testing
- AZD5718
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hamstring Injuries
Prevention of Hamstring Injuries in Football Players.
Introduction: The prevalence of hamstring injuries in football is high, causing an increase in the number of casualties and a high socio-economic cost.
- Trial name
- NCT05773404
- Testing
- Passive Neurodynamics and Passive axial hip mobilisation/distraction, Active therapy, 2.5.3. Combined therapy
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Universidad Católica de Ávila
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency).
- Trial name
- NCT00212147
- Testing
- General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Neoplasms, Cancer
Bioavailability and Food Effect Study of TKI258 (CSF Capsules vs. FMI Capsules)in Adult Patients With Advanced Solid Tumors
This study will evaluate the relative bioavailability of 2 oral formulations of TKI258, and the effect of food on the bioavailability of TKI258, in adult patients with advanced solid tumor
- Conditions
- Neoplasms, Cancer, Tumors
- Trial name
- NCT01030055
- Testing
- TKI258 (dovitinib)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Surgical Wound Infection
Relation of Skin Closure Method to Groin Wound Infections After Proximal Femoral Artery Exposure.
This study aims to asses whether the rate of surgical wound infections in vascular surgery procedures involving exposure of the proximal femoral artery can be reduced using a different skin closure technique.
- Trial name
- NCT03468621
- Testing
- Wound closure
- Where
- 3 sites in Finland
- Volunteers
- 300 people
- Sponsor
- Turku University Hospital
Hepatitis C
TMC435-TiDP16-C116 - Relative Bioavailability and Food Effect Study
The purpose of this study is to compare absorption of TMC435 formulated as 2 different types of capsules. After that, the absorption of one chosen TMC435 capsule will be compared when taken under fasting conditions or together…
- Trial name
- NCT01308606
- Testing
- TMC435 HPMC capsule, TMC435 HPMC or gelatin capsule, TMC435 gelatin capsule
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland